Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system
Rehder D, Haupt ETK, Müller A (2008)
MAGNETIC RESONANCE IN CHEMISTRY 46(S1): S24-S29.
Zeitschriftenaufsatz
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Autor*in
Rehder, Dieter;
Haupt, Erhard T. K.;
Müller, AchimUniBi ![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Einrichtung
Abstract / Bemerkung
Li+ ions can interplay with other cations intrinsically present in the intra- and extra-cellular space (i.e. Na+, K+, Mg2+ and Ca2+) and have therapeutic effects (e.g. in the treatment of bipolar disorder) or toxic effects (at higher doses), likely because Li+ interferes with the intra-/extra-cellular concentration gradients of the mentioned physiologically relevant cations. The cellular transmembrane transport can be modelled by molybdenum-oxide-based Keplerates, i.e. nano-sized porous capsules containing 132 Mo centres, monitored through Li-6/7 as well as Na-23 NMR spectroscopy. The effects on the transport of Li+ cations through the 'ion channels' of these model cells, caused by variations in water amount, temperature, and by the addition of organic cationic 'plugs' and the shift reagent [Dy(PPP)(2)](7-) are reported. In the investigated solvent systems, water acts as a transport mediator for Li+. Likewise, the counter-transport (Li+/Na+, Li+/K+, Li+/Cs+ and Li+/Ca2+) has been investigated by Li-7 NMR and, in the case of Li+/Na+ exchange, by Na-23 NMR, and it has been shown that most (in the case of Na+ and K+), all (Ca2+) or almost none (Cs+) of the Li cations is extruded from the internal sites of the artificial cell to the extra-cellular medium, while Na+, K+ and Ca2+ are partially incorporated. Copyright (C) 2008 John Wiley & Sons, Ltd.
Stichworte
lithium NMR;
cell model;
sodium NMR;
keplerate;
ion transport;
counter-transport
Erscheinungsjahr
2008
Zeitschriftentitel
MAGNETIC RESONANCE IN CHEMISTRY
Band
46
Ausgabe
S1
Seite(n)
S24-S29
ISSN
0749-1581
Page URI
https://pub.uni-bielefeld.de/record/1585448
Zitieren
Rehder D, Haupt ETK, Müller A. Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system. MAGNETIC RESONANCE IN CHEMISTRY. 2008;46(S1):S24-S29.
Rehder, D., Haupt, E. T. K., & Müller, A. (2008). Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system. MAGNETIC RESONANCE IN CHEMISTRY, 46(S1), S24-S29. https://doi.org/10.1002/mrc.2343
Rehder, Dieter, Haupt, Erhard T. K., and Müller, Achim. 2008. “Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system”. MAGNETIC RESONANCE IN CHEMISTRY 46 (S1): S24-S29.
Rehder, D., Haupt, E. T. K., and Müller, A. (2008). Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system. MAGNETIC RESONANCE IN CHEMISTRY 46, S24-S29.
Rehder, D., Haupt, E.T.K., & Müller, A., 2008. Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system. MAGNETIC RESONANCE IN CHEMISTRY, 46(S1), p S24-S29.
D. Rehder, E.T.K. Haupt, and A. Müller, “Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system”, MAGNETIC RESONANCE IN CHEMISTRY, vol. 46, 2008, pp. S24-S29.
Rehder, D., Haupt, E.T.K., Müller, A.: Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system. MAGNETIC RESONANCE IN CHEMISTRY. 46, S24-S29 (2008).
Rehder, Dieter, Haupt, Erhard T. K., and Müller, Achim. “Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system”. MAGNETIC RESONANCE IN CHEMISTRY 46.S1 (2008): S24-S29.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
4 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Biomimetic Approach for Ion Channels Based on Surfactant Encapsulated Spherical Porous Metal-Oxide Capsules.
Mahon E, Garai S, Müller A, Barboiu M., Adv Mater 27(35), 2015
PMID: 26248195
Mahon E, Garai S, Müller A, Barboiu M., Adv Mater 27(35), 2015
PMID: 26248195
Capsules with highly active pores and interiors: versatile platforms at the nanoscale.
Müller A, Gouzerh P., Chemistry 20(17), 2014
PMID: 24644235
Müller A, Gouzerh P., Chemistry 20(17), 2014
PMID: 24644235
From linking of metal-oxide building blocks in a dynamic library to giant clusters with unique properties and towards adaptive chemistry.
Müller A, Gouzerh P., Chem Soc Rev 41(22), 2012
PMID: 22948798
Müller A, Gouzerh P., Chem Soc Rev 41(22), 2012
PMID: 22948798
Hydrophobic interactions and clustering in a porous capsule: option to remove hydrophobic materials from water.
Schäffer C, Todea AM, Bögge H, Petina OA, Rehder D, Haupt ET, Müller A., Chemistry 17(35), 2011
PMID: 21748814
Schäffer C, Todea AM, Bögge H, Petina OA, Rehder D, Haupt ET, Müller A., Chemistry 17(35), 2011
PMID: 21748814
38 References
Daten bereitgestellt von Europe PubMed Central.
Birch, 2004
Randomized, dose-finding phase III study of lithium gamolenate in patients with advanced pancreatic adenocarcinoma.
Johnson CD, Puntis M, Davidson N, Todd S, Bryce R., Br J Surg 88(5), 2001
PMID: 11350436
Johnson CD, Puntis M, Davidson N, Todd S, Bryce R., Br J Surg 88(5), 2001
PMID: 11350436
Is competition between Li+ and Mg2+ the underlying theme in the proposed mechanisms for the pharmacological action of lithium salts in bipolar disorder?
Mota de Freitas D, Castro MM, Geraldes CF., Acc. Chem. Res. 39(4), 2006
PMID: 16618096
Mota de Freitas D, Castro MM, Geraldes CF., Acc. Chem. Res. 39(4), 2006
PMID: 16618096
Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders.
Kozikowski AP, Gaisina IN, Yuan H, Petukhov PA, Blond SY, Fedolak A, Caldarone B, McGonigle P., J. Am. Chem. Soc. 129(26), 2007
PMID: 17552518
Kozikowski AP, Gaisina IN, Yuan H, Petukhov PA, Blond SY, Fedolak A, Caldarone B, McGonigle P., J. Am. Chem. Soc. 129(26), 2007
PMID: 17552518
Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
Finlay D, Patel S, Dickson LM, Shpiro N, Marquez R, Rhodes CJ, Sutherland C., BMC Mol. Biol. 5(), 2004
PMID: 15350195
Finlay D, Patel S, Dickson LM, Shpiro N, Marquez R, Rhodes CJ, Sutherland C., BMC Mol. Biol. 5(), 2004
PMID: 15350195
Genome-wide association in bipolar.
Gershon ES, Liu C, Badner JA., Mol. Psychiatry 13(1), 2008
PMID: 18084308
Gershon ES, Liu C, Badner JA., Mol. Psychiatry 13(1), 2008
PMID: 18084308
Enhanced Na-Li countertransport: a marker of inherited susceptibility to type 2 diabetes.
Vaccaro O, Cuomo V, Trevisan M, Cirillo M, Panarelli W, Laurenzi M, Mancini M, Riccardi G; Gubbio Study Research Group., Int J Epidemiol 34(5), 2005
PMID: 16087689
Vaccaro O, Cuomo V, Trevisan M, Cirillo M, Panarelli W, Laurenzi M, Mancini M, Riccardi G; Gubbio Study Research Group., Int J Epidemiol 34(5), 2005
PMID: 16087689
Red-cell lithium-sodium countertransport and renal lithium clearance in hypertension.
Weder AB., N. Engl. J. Med. 314(4), 1986
PMID: 3941708
Weder AB., N. Engl. J. Med. 314(4), 1986
PMID: 3941708
Cordero, Dalton Trans. (), 2008
23Na-nuclear magnetic resonance investigation of gramicidin-induced ion transport through membranes under equilibrium conditions.
Buster DC, Hinton JF, Millett FS, Shungu DC., Biophys. J. 53(2), 1988
PMID: 2449917
Buster DC, Hinton JF, Millett FS, Shungu DC., Biophys. J. 53(2), 1988
PMID: 2449917
Evaluation of extra- and intracellular apparent diffusion coefficient of sodium in rat skeletal muscle: effects of prolonged ischemia.
Babsky AM, Topper S, Zhang H, Gao Y, James JR, Hekmatyar SK, Bansal N., Magn Reson Med 59(3), 2008
PMID: 18306401
Babsky AM, Topper S, Zhang H, Gao Y, James JR, Hekmatyar SK, Bansal N., Magn Reson Med 59(3), 2008
PMID: 18306401
Delort, Methods Biotechnol. 16(), 2004
(7)Li NMR and two-dimensional exchange study of lithium dynamics in monoclinic Li(3)V(2)(PO(4))(3).
Cahill LS, Chapman RP, Britten JF, Goward GR., J Phys Chem B 110(14), 2006
PMID: 16599482
Cahill LS, Chapman RP, Britten JF, Goward GR., J Phys Chem B 110(14), 2006
PMID: 16599482
Ramaprasad, Prog. Nucl. Magn. Reson. Spectrosc. 47(), 2005
Artificial cells: temperature-dependent, reversible Li+-ion uptake/release equilibrium at metal oxide nanocontainer pores.
Muller A, Rehder D, Haupt ET, Merca A, Bogge H, Schmidtmann M, Heinze-Bruckner G., Angew. Chem. Int. Ed. Engl. 43(34), 2004
PMID: 15340945
Muller A, Rehder D, Haupt ET, Merca A, Bogge H, Schmidtmann M, Heinze-Bruckner G., Angew. Chem. Int. Ed. Engl. 43(34), 2004
PMID: 15340945
AUTHOR UNKNOWN, Angew. Chem. Int. Ed. 43(), 2004
Haupt, Chem. Commun. (), 2005
Haupt, Chem. Eur. J. (), 2008
Countercation transport modeled by porous spherical molybdenum oxide based nanocapsules.
Rehder D, Haupt ET, Bogge H, Muller A., Chem Asian J 1(1-2), 2006
PMID: 17441040
Rehder D, Haupt ET, Bogge H, Muller A., Chem Asian J 1(1-2), 2006
PMID: 17441040
Merca, Chem. Eur. J. 13(), 2007
Inorganic molecular capsules: from structure to function.
Cronin L., Angew. Chem. Int. Ed. Engl. 45(22), 2006
PMID: 16683287
Cronin L., Angew. Chem. Int. Ed. Engl. 45(22), 2006
PMID: 16683287
Polyoxometalate clusters, nanostructures and materials: from self assembly to designer materials and devices.
Long DL, Burkholder E, Cronin L., Chem Soc Rev 36(1), 2006
PMID: 17173149
Long DL, Burkholder E, Cronin L., Chem Soc Rev 36(1), 2006
PMID: 17173149
Long, Chem. Eur. J. 12(), 2006
Volkmer, J. Am. Chem. Soc. 122(), 2000
Polyoxometalates with internal cavities: redox activity, basicity, and cation encapsulation in [Xn+P5W30O110](15-n)- Preyssler complexes, with X = Na+, Ca2+, Y3+, La3+, Ce3+, and Th4+.
Fernandez JA, Lopez X, Bo C, de Graaf C, Baerends EJ, Poblet JM., J. Am. Chem. Soc. 129(40), 2007
PMID: 17854187
Fernandez JA, Lopez X, Bo C, de Graaf C, Baerends EJ, Poblet JM., J. Am. Chem. Soc. 129(40), 2007
PMID: 17854187
For K+ channels, Na+ is the new Ca2+.
Bhattacharjee A, Kaczmarek LK., Trends Neurosci. 28(8), 2005
PMID: 15979166
Bhattacharjee A, Kaczmarek LK., Trends Neurosci. 28(8), 2005
PMID: 15979166
Valiyaveetil, Science 414(), 2006
Karkhaneei, J. Inclusion Phenom. Macrocycl. Chem. 40(), 2001
Crown ether appended cyclam receptors for cationic guests.
Bernhardt PV, Hayes EJ., Inorg Chem 41(11), 2002
PMID: 12033897
Bernhardt PV, Hayes EJ., Inorg Chem 41(11), 2002
PMID: 12033897
von, Angew. Chem. Int. Ed. 46(), 2007
Perrin, Chem. Rev. 90(), 1990
Atkins, 2006
Müller, C. R. Chim. 8(), 2005
Xia, Nat. Rev. Neurosci. 8(), 2005
Drakenberg, 2006
Trapping cations in specific positions in tuneable "artificial cell" channels: new nanochemistry perspectives.
Muller A, Das SK, Talismanov S, Roy S, Beckmann E, Bogge H, Schmidtmann M, Merca A, Berkle A, Allouche L, Zhou Y, Zhang L., Angew. Chem. Int. Ed. Engl. 42(41), 2003
PMID: 14595625
Muller A, Das SK, Talismanov S, Roy S, Beckmann E, Bogge H, Schmidtmann M, Merca A, Berkle A, Allouche L, Zhou Y, Zhang L., Angew. Chem. Int. Ed. Engl. 42(41), 2003
PMID: 14595625
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