Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics

Müller K, Falck G (2018)
Antibodies 7(1): 4.

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Journal Article | Original Article | Published | English
Abstract / Notes
Strategies for site-specific modification of proteins have increased in number, complexity, and specificity over the last years. Such modifications hold the promise to broaden the use of existing biopharmaceuticals or to tailor novel proteins for therapeutic or diagnostic applications. The recent quest for next-generation antibody–drug conjugates (ADCs) sparked research into techniques with site selectivity. While purely chemical approaches often impede control of dosage or locus of derivatization, naturally occurring enzymes and proteins bear the ability of co- or post-translational protein modifications at particular residues, thus enabling unique coupling reactions or protein fusions. This review provides a general overview and focuses on chemo-enzymatic methods including enzymes such as formylglycine-generating enzyme, sortase, and transglutaminase. Applications for the conjugation of antibodies and antibody mimetics are reported. View Full-Text
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Article Processing Charge funded by the Deutsche Forschungsgemeinschaft and the Open Access Publication Fund of Bielefeld University.
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Müller K, Falck G. Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics. Antibodies. 2018;7(1): 4.
Müller, K., & Falck, G. (2018). Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics. Antibodies, 7(1), 4. doi:10.3390/antib7010004
Müller, K., and Falck, G. (2018). Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics. Antibodies 7:4.
Müller, K., & Falck, G., 2018. Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics. Antibodies, 7(1): 4.
K. Müller and G. Falck, “Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics”, Antibodies, vol. 7, 2018, : 4.
Müller, K., Falck, G.: Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics. Antibodies. 7, : 4 (2018).
Müller, Kristian, and Falck, Georg. “Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics”. Antibodies 7.1 (2018): 4.
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