Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)

Kouam A, Bissoue A, Tcho A, Happi E, Waffo A, Sewald N, Wansi J (2018)
Molecules 23(1): 13.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Three new prenylated furoquinoline alkaloids named lecomtequinoline A (1), B (2), and C (3), together with the known compounds anhydroevoxine (4), evoxine (5), dictamnine (6), N-methylflindersine (7), evoxanthine (8), hesperidin, lupeol, β-sitosterol, stigmasterol, β-sitosterol-3-O-β-d-glucopyranoside, stearic acid, and myristyl alcohol, were isolated by bioassay-guided fractionation of the methanolic extracts of leaves and stem of Vepris lecomteana. The structures of compounds were determined by spectroscopic methods (NMR, MS, UV, and IR) and by comparison with previously reported data. Crude extracts of leaves and stem displayed high antimicrobial activity, with Minimum Inhibitory Concentration (MIC) (values of 10.1–16.5 and 10.2–20.5 µg/mL, respectively, against Escherichia coli, Bacillus subtilis, Pseudomonas agarici, Micrococcus luteus, and Staphylococcus warneri, while compounds 1–6 showed values ranging from 11.1 to 18.7 µg/mL or were inactive, suggesting synergistic effect. The extracts may find application in crude drug preparations in Western Africa where Vepris lecomteana is endemic, subject to negative toxicity results in vivo
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Zeitschriftentitel
Molecules
Band
23
Zeitschriftennummer
1
Artikelnummer
13
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Article Processing Charge funded by the Deutsche Forschungsgemeinschaft and the Open Access Publication Fund of Bielefeld University.
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Kouam A, Bissoue A, Tcho A, et al. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules. 2018;23(1): 13.
Kouam, A., Bissoue, A., Tcho, A., Happi, E., Waffo, A., Sewald, N., & Wansi, J. (2018). Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules, 23(1), 13. doi:10.3390/molecules23010013
Kouam, A., Bissoue, A., Tcho, A., Happi, E., Waffo, A., Sewald, N., and Wansi, J. (2018). Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules 23:13.
Kouam, A., et al., 2018. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules, 23(1): 13.
A. Kouam, et al., “Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)”, Molecules, vol. 23, 2018, : 13.
Kouam, A., Bissoue, A., Tcho, A., Happi, E., Waffo, A., Sewald, N., Wansi, J.: Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules. 23, : 13 (2018).
Kouam, Ariane, Bissoue, Achille, Tcho, Alain, Happi, Emmanuel, Waffo, Alain, Sewald, Norbert, and Wansi, Jean. “Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)”. Molecules 23.1 (2018): 13.
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2018-02-06T15:29:38Z