Synthesis and biological activities of new bis-indole derivatives via microwave irradiation

Halawa AH, Bedair AH, El-Agrody AM, Eliwa EM, Frese M, Sewald N, Shaaban M (2017)
ZEITSCHRIFT FUER NATURFORSCHUNG SECTION B 72(9): 639-646.

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Abstract
Three new series of bis-indole derivatives were synthesized based on p-phenylenediamine (2-4, 5 and 6) and 4,4'-ethylenedianiline moieties (7-9) using facile and efficient condensation of three positional isomeric indole-carboxaldehyde derivatives (1a-c) with bifunctional amines upon microwave irradiation. The symmetric dimeric indole derivatives 2-4 as well as non-symmetric analogues 5 and 6 were obtained by in situ condensation of the respective positional 3-, 2- and 5-isomeric indole-carboxaldehydes with p-phenylenediamine, while compounds 7-9 resulted from respective condensation based on 4,4'-ethylenedianiline. Structures of the obtained compounds were deduced by advanced spectroscopic methods (H-1 NMR, C-13 NMR and MS). In agar diffusion assay, derivative 6 showed moderate antibacterial activity against various Gram positive and negative bacteria, while derivative 7 displayed moderate activity against several Gram positive bacteria. However, in Resazurin assay employing the human cervix carcinoma cell line (KB-3-1), derivatives 2-9 turned out to be inactive.
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Halawa AH, Bedair AH, El-Agrody AM, et al. Synthesis and biological activities of new bis-indole derivatives via microwave irradiation. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION B. 2017;72(9):639-646.
Halawa, A. H., Bedair, A. H., El-Agrody, A. M., Eliwa, E. M., Frese, M., Sewald, N., & Shaaban, M. (2017). Synthesis and biological activities of new bis-indole derivatives via microwave irradiation. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION B, 72(9), 639-646. doi:10.1515/znb-2017-0039
Halawa, A. H., Bedair, A. H., El-Agrody, A. M., Eliwa, E. M., Frese, M., Sewald, N., and Shaaban, M. (2017). Synthesis and biological activities of new bis-indole derivatives via microwave irradiation. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION B 72, 639-646.
Halawa, A.H., et al., 2017. Synthesis and biological activities of new bis-indole derivatives via microwave irradiation. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION B, 72(9), p 639-646.
A.H. Halawa, et al., “Synthesis and biological activities of new bis-indole derivatives via microwave irradiation”, ZEITSCHRIFT FUER NATURFORSCHUNG SECTION B, vol. 72, 2017, pp. 639-646.
Halawa, A.H., Bedair, A.H., El-Agrody, A.M., Eliwa, E.M., Frese, M., Sewald, N., Shaaban, M.: Synthesis and biological activities of new bis-indole derivatives via microwave irradiation. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION B. 72, 639-646 (2017).
Halawa, Ahmed H., Bedair, Ahmed H., El-Agrody, Ahmed M., Eliwa, Essam M., Frese, Marcel, Sewald, Norbert, and Shaaban, Mohamed. “Synthesis and biological activities of new bis-indole derivatives via microwave irradiation”. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION B 72.9 (2017): 639-646.
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