Current psychiatric disorders in patients with epilepsy are predicted by maltreatment experiences during childhood

Labudda K, Illies D, Herzig C, Schröder K, Bien CG, Neuner F (2017)
Epilepsy Research 135: 43-49.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Purpose: Childhood maltreatment has been shown to be a risk factor for the development of psychiatric disorders. Although the prevalence of psychiatric disorders is high in epilepsy patients, it is unknown if childhood maltreatment experiences are elevated compared to the normal population and if early maltreatment is a risk factor for current psychiatric comorbidities in epilepsy patients. This is the main purpose of this study. Methods: Structured interviews were used to assess current Axis I diagnoses in 120 epilepsy patients from a tertiary Epilepsy Center (34 TLE patients, 86 non-TLE patients). Childhood maltreatment in the family and peer victimization were assessed with validated questionnaires. Patients' maltreatment scores were compared with those of a representative matched control group. Logistic regression analysis was conducted to assess the potential impact of childhood maltreatment on current psychiatric comorbidity in epilepsy patients. Results: Compared to a matched control group, epilepsy patients had higher emotional and sexual maltreatment scores. Patients with a current psychiatric diagnosis reported more family and peer maltreatment than patients without a psychiatric disorder. Family maltreatment scores predicted the likelihood of a current psychiatric disorder. TLE patients did not differ from non-TLE patients according to maltreatment experiences and rates of current psychiatric disorders. Conclusion: Our findings suggest that in epilepsy patients emotional and sexual childhood maltreatment is experienced more often than in the normal population and that early maltreatment is a general risk factor for psychiatric comorbidities in this group.
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Epilepsy Research
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135
Seite
43-49
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Labudda K, Illies D, Herzig C, Schröder K, Bien CG, Neuner F. Current psychiatric disorders in patients with epilepsy are predicted by maltreatment experiences during childhood. Epilepsy Research. 2017;135:43-49.
Labudda, K., Illies, D., Herzig, C., Schröder, K., Bien, C. G., & Neuner, F. (2017). Current psychiatric disorders in patients with epilepsy are predicted by maltreatment experiences during childhood. Epilepsy Research, 135, 43-49. doi:10.1016/j.eplepsyres.2017.06.005
Labudda, K., Illies, D., Herzig, C., Schröder, K., Bien, C. G., and Neuner, F. (2017). Current psychiatric disorders in patients with epilepsy are predicted by maltreatment experiences during childhood. Epilepsy Research 135, 43-49.
Labudda, K., et al., 2017. Current psychiatric disorders in patients with epilepsy are predicted by maltreatment experiences during childhood. Epilepsy Research, 135, p 43-49.
K. Labudda, et al., “Current psychiatric disorders in patients with epilepsy are predicted by maltreatment experiences during childhood”, Epilepsy Research, vol. 135, 2017, pp. 43-49.
Labudda, K., Illies, D., Herzig, C., Schröder, K., Bien, C.G., Neuner, F.: Current psychiatric disorders in patients with epilepsy are predicted by maltreatment experiences during childhood. Epilepsy Research. 135, 43-49 (2017).
Labudda, Kirsten, Illies, Dominik, Herzig, Cornelia, Schröder, Katharina, Bien, Christian G., and Neuner, Frank. “Current psychiatric disorders in patients with epilepsy are predicted by maltreatment experiences during childhood”. Epilepsy Research 135 (2017): 43-49.

53 References

Daten bereitgestellt von Europe PubMed Central.

Neuropsychiatric morbidity in focal epilepsy.
Adams SJ, O'Brien TJ, Lloyd J, Kilpatrick CJ, Salzberg MR, Velakoulis D., Br J Psychiatry 192(6), 2008
PMID: 18515901
Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy.
Ali I, O'Brien P, Kumar G, Zheng T, Jones NC, Pinault D, French C, Morris MJ, Salzberg MR, O'Brien TJ., PLoS ONE 8(6), 2013
PMID: 23825595
The quality of life of older people with epilepsy: findings from a UK community study.
Baker GA, Jacoby A, Buck D, Brooks J, Potts P, Chadwick DW., Seizure 10(2), 2001
PMID: 11407951
Prevalence of anxiety disorders in patients with refractory focal epilepsy--a prospective clinic based survey.
Brandt C, Schoendienst M, Trentowska M, May TW, Pohlmann-Eden B, Tuschen-Caffier B, Schrecke M, Fueratsch N, Witte-Boelt K, Ebner A., Epilepsy Behav 17(2), 2010
PMID: 20075009
The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes.
Carr CP, Martins CM, Stingel AM, Lemgruber VB, Juruena MF., J. Nerv. Ment. Dis. 201(12), 2013
PMID: 24284634
Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging.
Dannlowski U, Stuhrmann A, Beutelmann V, Zwanzger P, Lenzen T, Grotegerd D, Domschke K, Hohoff C, Ohrmann P, Bauer J, Lindner C, Postert C, Konrad C, Arolt V, Heindel W, Suslow T, Kugel H., Biol. Psychiatry 71(4), 2011
PMID: 22112927

Ehlers, 1996
Depression in patients with refractory temporal lobe epilepsy.
Goncalves EB, Cendes F., Arq Neuropsiquiatr 69(5), 2011
PMID: 22042180
Are children with epilepsy at greater risk for bullying than their peers?
Hamiwka LD, Yu CG, Hamiwka LA, Sherman EM, Anderson B, Wirrell E., Epilepsy Behav 15(4), 2009
PMID: 19631586
Frequency of child maltreatment in a representative sample of the German population.
Iffland B, Brahler E, Neuner F, Hauser W, Glaesmer H., BMC Public Health 13(), 2013
PMID: 24139055
Early childhood trauma and hippocampal volumes in patients with epileptic and psychogenic seizures.
Johnstone B, Velakoulis D, Yuan CY, Ang A, Steward C, Desmond P, O'Brien TJ., Epilepsy Behav 64(Pt A), 2016
PMID: 27743551
Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence.
Kanner AM, Schachter SC, Barry JJ, Hesdorffer DC, Hersdorffer DC, Mula M, Trimble M, Hermann B, Ettinger AE, Dunn D, Caplan R, Ryvlin P, Gilliam F, LaFrance WC Jr., Epilepsy Behav 24(2), 2012
PMID: 22632406
[The German Version of the Childhood Trauma Questionnaire (CTQ): psychometric characteristics in a representative sample of the general population].
Klinitzke G, Romppel M, Hauser W, Brahler E, Glaesmer H., Psychother Psychosom Med Psychol 62(2), 2011
PMID: 22203470
Early life stress as an influence on limbic epilepsy: an hypothesis whose time has come?
Koe AS, Jones NC, Salzberg MR., Front Behav Neurosci 3(), 2009
PMID: 19838325
Early life maternal separation stress augmentation of limbic epileptogenesis: the role of corticosterone and HPA axis programming.
Koe AS, Salzberg MR, Morris MJ, O'Brien TJ, Jones NC., Psychoneuroendocrinology 42(), 2014
PMID: 24636509
The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors.
Kumar G, Couper A, O'Brien TJ, Salzberg MR, Jones NC, Rees SM, Morris MJ., Psychoneuroendocrinology 32(7), 2007
PMID: 17614213
Mesiotemporal volume loss associated with disorder severity: a VBM study in borderline personality disorder.
Labudda K, Kreisel S, Beblo T, Mertens M, Kurlandchikov O, Bien CG, Driessen M, Woermann FG., PLoS ONE 8(12), 2013
PMID: 24367606
Combined dexamethasone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II.
Lammers CH, Garcia-Borreguero D, Schmider J, Gotthardt U, Dettling M, Holsboer F, Heuser IJ., Biol. Psychiatry 38(12), 1995
PMID: 8750038
Childhood trauma in patients with self-reported stress-precipitated seizures.
Lee I, Strawn JR, Dwivedi AK, Walters M, Fleck A, Schwieterman D, Haut SR, Polak E, Privitera M., Epilepsy Behav 51(), 2015
PMID: 26295447
The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology.
Martin EI, Ressler KJ, Binder E, Nemeroff CB., Clin. Lab. Med. 30(4), 2010
PMID: 20832657
Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy.
Mazarati AM, Shin D, Kwon YS, Bragin A, Pineda E, Tio D, Taylor AN, Sankar R., Neurobiol. Dis. 34(3), 2009
PMID: 19285131
A community study of the presence of anxiety disorder in people with epilepsy.
Mensah SA, Beavis JM, Thapar AK, Kerr MP., Epilepsy Behav 11(1), 2007
PMID: 17532266
Comorbidity of ictal fear and panic disorder.
Mintzer S, Lopez F., Epilepsy Behav 3(4), 2002
PMID: 12609330
Corticotropin-releasing hormone and the hypothalamic-pituitary-adrenal axis in psychiatric disease.
Naughton M, Dinan TG, Scott LV., Handb Clin Neurol 124(), 2014
PMID: 25248580
A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder.
O'Doherty DC, Chitty KM, Saddiqui S, Bennett MR, Lagopoulos J., Psychiatry Res 232(1), 2015
PMID: 25735885
Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy.
Perini GI, Tosin C, Carraro C, Bernasconi G, Canevini MP, Canger R, Pellegrini A, Testa G., J. Neurol. Neurosurg. Psychiatry 61(6), 1996
PMID: 8971108
Emotional trauma and abuse in patients with psychogenic nonepileptic seizures.
Proenca IC, Castro LH, Jorge CL, Marchetti RL., Epilepsy Behav 20(2), 2011
PMID: 21315658
Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis.
Quiske A, Helmstaedter C, Lux S, Elger CE., Epilepsy Res. 39(2), 2000
PMID: 10759300
Depression and anxiety before and after temporal lobe epilepsy surgery.
Reuber M, Andersen B, Elger CE, Helmstaedter C., Seizure 13(2), 2004
PMID: 15129842
Early postnatal stress confers enduring vulnerability to limbic epileptogenesis.
Salzberg M, Kumar G, Supit L, Jones NC, Morris MJ, Rees S, O'Brien TJ., Epilepsia 48(11), 2007
PMID: 17999745
Peer victimization predicts psychological symptoms beyond the effects of child maltreatment.
Sansen LM, Iffland B, Neuner F., Psychiatry Res 220(3), 2014
PMID: 25440718
The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.
Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC., J Clin Psychiatry 59 Suppl 20(), 1998
PMID: 9881538
Insular and hippocampal gray matter volume reductions in patients with major depressive disorder.
Stratmann M, Konrad C, Kugel H, Krug A, Schoning S, Ohrmann P, Uhlmann C, Postert C, Suslow T, Heindel W, Arolt V, Kircher T, Dannlowski U., PLoS ONE 9(7), 2014
PMID: 25051163
Prevalence of Psychopathology in Dutch Epilepsy Inpatients: A Comparative Study.
Swinkels WA, Kuyk J, de Graaf EH, van Dyck R, Spinhoven P., Epilepsy Behav 2(5), 2001
PMID: 12609281
Developmental neurobiology of childhood stress and trauma.
Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP., Psychiatr. Clin. North Am. 25(2), 2002
PMID: 12136507
Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum.
Teicher MH, Anderson CM, Polcari A., Proc. Natl. Acad. Sci. U.S.A. 109(9), 2012
PMID: 22331913
Do depression symptoms predict seizure frequency--or vice versa?
Thapar A, Roland M, Harold G., J Psychosom Res 59(5), 2005
PMID: 16253616
Early life stress, HPA axis, and depression
Tofoli, Psychol. Neurosci. 4(), 2011
Psychiatric comorbidities among patients with epilepsy in Montenegro.
Vujisic S, Vodopic S, Radulovic L, Injac-Stevovic L., Acta Clin Croat 53(4), 2014
PMID: 25868308
Adult health status of women with histories of childhood abuse and neglect.
Walker EA, Gelfand A, Katon WJ, Koss MP, Von Korff M, Bernstein D, Russo J., Am. J. Med. 107(4), 1999
PMID: 10527034
Childhood maltreatment and personality disorders in the USA: specificity of effects and the impact of gender.
Waxman R, Fenton MC, Skodol AE, Grant BF, Hasin D., Personal Ment Health 8(1), 2013
PMID: 24532553
[The German version of the Childhood Trauma Questionnaire (CTQ): preliminary psychometric properties].
Wingenfeld K, Spitzer C, Mensebach C, Grabe HJ, Hill A, Gast U, Schlosser N, Hopp H, Beblo T, Driessen M., Psychother Psychosom Med Psychol 60(11), 2010
PMID: 20200804
Health behavior in teens with epilepsy: how do they compare with controls?
Yu CG, Lee A, Wirrell E, Sherman EM, Hamiwka L., Epilepsy Behav 13(1), 2008
PMID: 18555203
Impairment of inhibitory control of the hypothalamic pituitary adrenocortical system in epilepsy.
Zobel A, Wellmer J, Schulze-Rauschenbach S, Pfeiffer U, Schnell S, Elger C, Maier W., Eur Arch Psychiatry Clin Neurosci 254(5), 2004
PMID: 15365705
Seizure occurrence and the circadian rhythm of cortisol: a systematic review.
van Campen JS, Valentijn FA, Jansen FE, Joels M, Braun KP., Epilepsy Behav 47(), 2015
PMID: 25982883

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