Hydrolysis of cis-and transplatin: structure and reactivity of the aqua complexes in a solvent free environment

Corinti D, Coletti C, Re N, Piccirillo S, Giampa M, Crestoni ME, Fornarini S (2017)
RSC ADVANCES 7(26): 15877-15884.

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Journal Article | Original Article | Published | English

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Abstract
Singly aquated and diaquated species are key intermediates in the mechanism responsible for the antitumor activity of cisplatin. Aqua complexes [PtX(NH3)(2)(H2O)](+) (X = Cl, OH), obtained in water by hydrolysis of cisplatin and of the inactive isomer transplatin, are transferred into the gas-phase by electrospray ionization. The so-formed ions, cis-and trans-[PtX(NH3)(2)(H2O)](+), have been allowed to react with selected ligands, representing platination targets in the biological environment. The reaction kinetics monitored in the gas-phase show consistently higher reactivity for the chloro complexes, [PtCl(NH3)(2)(H2O)](+), with respect to the hydroxo counterparts, [Pt(OH)(NH3)(2)(H2O)](+). The latter species, both cis-and trans-isomers, have been assayed by IRMPD spectroscopy in the NH/OH stretching region and their vibrational and geometric features are compared with the ones pertaining to the already described chloro complexes, cis-and trans-[PtCl(NH3)(2)(H2O)](+).
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Corinti D, Coletti C, Re N, et al. Hydrolysis of cis-and transplatin: structure and reactivity of the aqua complexes in a solvent free environment. RSC ADVANCES. 2017;7(26):15877-15884.
Corinti, D., Coletti, C., Re, N., Piccirillo, S., Giampa, M., Crestoni, M. E., & Fornarini, S. (2017). Hydrolysis of cis-and transplatin: structure and reactivity of the aqua complexes in a solvent free environment. RSC ADVANCES, 7(26), 15877-15884. doi:10.1039/c7ra01182b
Corinti, D., Coletti, C., Re, N., Piccirillo, S., Giampa, M., Crestoni, M. E., and Fornarini, S. (2017). Hydrolysis of cis-and transplatin: structure and reactivity of the aqua complexes in a solvent free environment. RSC ADVANCES 7, 15877-15884.
Corinti, D., et al., 2017. Hydrolysis of cis-and transplatin: structure and reactivity of the aqua complexes in a solvent free environment. RSC ADVANCES, 7(26), p 15877-15884.
D. Corinti, et al., “Hydrolysis of cis-and transplatin: structure and reactivity of the aqua complexes in a solvent free environment”, RSC ADVANCES, vol. 7, 2017, pp. 15877-15884.
Corinti, D., Coletti, C., Re, N., Piccirillo, S., Giampa, M., Crestoni, M.E., Fornarini, S.: Hydrolysis of cis-and transplatin: structure and reactivity of the aqua complexes in a solvent free environment. RSC ADVANCES. 7, 15877-15884 (2017).
Corinti, Davide, Coletti, Cecilia, Re, Nazzareno, Piccirillo, Susanna, Giampa, Marco, Crestoni, Maria Elisa, and Fornarini, Simonetta. “Hydrolysis of cis-and transplatin: structure and reactivity of the aqua complexes in a solvent free environment”. RSC ADVANCES 7.26 (2017): 15877-15884.
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