Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae)

Atangana AF, Toze FAA, Langat MK, Happi EN, Mbaze LLM'a, Mulholland DA, Waffo AFK, Sewald N, Wansi JD (2017)
PHYTOCHEMISTRY LETTERS 19: 191-195.

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Abstract
Two new acridone alkaloids, verdoocridone A (1) and B (4), together with fifteen known compounds were isolated from methanol extracts of the roots and leaves of Vepris verdoorniana. The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI-and ESIMS). The C-13 NMR values of 1,2,3,5-tetramethoxy-N-methylacridone (2) and 5-methoxyaborinine (3) are also reported. The crude extracts and compounds (1-6) were tested for their antimicrobial activity. The test delivered moderate activities for crude extracts and compounds 1, 5 and 6 against the bacterium Staphylococcus aureus and the fungi Mucor meihei and Candida albicans with MIC values between 115 and 180 mu g/mL for extracts and between 21.3 and 29.4 mu M for compounds, compared to gentamycin with 0.2 mu M and nystatin with 5.2 mu M against both fungi. The determination of the radical scanvenging activity using 1,1-dephenyl-2-picrylhydrazyl (DPPH) assay gave moderate antioxidant values for all tested compounds, with IC50 between 0.29 and 0.41 mu M, compared to the standard 3-t-butyl-4hydroxyanisole (BHA) displaying 0.03 mu M. (C) 2017 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
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Atangana AF, Toze FAA, Langat MK, et al. Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae). PHYTOCHEMISTRY LETTERS. 2017;19:191-195.
Atangana, A. F., Toze, F. A. A., Langat, M. K., Happi, E. N., Mbaze, L. L. M. 'a, Mulholland, D. A., Waffo, A. F. K., et al. (2017). Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae). PHYTOCHEMISTRY LETTERS, 19, 191-195. doi:10.1016/j.phytol.2017.01.001
Atangana, A. F., Toze, F. A. A., Langat, M. K., Happi, E. N., Mbaze, L. L. M. 'a, Mulholland, D. A., Waffo, A. F. K., Sewald, N., and Wansi, J. D. (2017). Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae). PHYTOCHEMISTRY LETTERS 19, 191-195.
Atangana, A.F., et al., 2017. Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae). PHYTOCHEMISTRY LETTERS, 19, p 191-195.
A.F. Atangana, et al., “Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae)”, PHYTOCHEMISTRY LETTERS, vol. 19, 2017, pp. 191-195.
Atangana, A.F., Toze, F.A.A., Langat, M.K., Happi, E.N., Mbaze, L.L.M.'a, Mulholland, D.A., Waffo, A.F.K., Sewald, N., Wansi, J.D.: Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae). PHYTOCHEMISTRY LETTERS. 19, 191-195 (2017).
Atangana, Albert Fouda, Toze, Flavien Aristide Alfred, Langat, Moses K., Happi, Emmanuel Ngeufa, Mbaze, Luc Leonard Meva'a, Mulholland, Dulcie A., Waffo, Alain Francois Kamdem, Sewald, Norbert, and Wansi, Jean Duplex. “Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae)”. PHYTOCHEMISTRY LETTERS 19 (2017): 191-195.
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