Zygosity Determination in Twin Studies: a Validation of Zygosity Questionnaires Using DNA in the German TwinLife Study

Lenau F, Hahn E, Peters A-L, Gottschling J, Thiel W, Spinath FM (2017) TwinLife Working Paper Series; 01.
Bielefeld: Project TwinLife "Genetic and social causes of life chances" (Universität Bielefeld / Universität des Saarlandes).

Download
OA 1.15 MB
Diskussionspapier | Veröffentlicht | Englisch
Volltext vorhanden für diesen Nachweis
Autor
; ; ; ; ;
Abstract / Bemerkung
Zygosity determination using similarity ratings is frequently applied in twin studies. A correct determination of zygosity is essential for the estimation of heritability and environmental influences on phenotypes. Therefore, the present study examined the validity of two similarity questionnaires used in the German TwinLife study, in which data from 4,097 twin pairs and their families were assessed: twin children’s zygosities were determined with the Zygosity Questionnaire for Young Twins, which was administered in parent-report form. For adolescent twins, the Self Report Zygosity Questionnaire was used. For the present validation analyses, DNA samples of N = 328 twin pairs were collected via buccal swabs. In this DNA subsample, questionnaires were filled out by parents for n = 212 (aged 4 to 12 years) twin pairs while self-reports were collected from n = 116 adolescent twins (16 to 23 years of age). Using DNA-based zygosity as criteria, correct classification rates of 97% for parent- and 92% for self-reports were established and cross-validated. Additionally, classification rates based on a single item and variants of questionnaire based zygosity determination used in other twin studies were calculated and compared. Implications of incorrectly classified zygosity on genetic and environmental estimates in twin studies are discussed.
Erscheinungsjahr
Band
01
Seite
13
ISSN
PUB-ID

Zitieren

Lenau F, Hahn E, Peters A-L, Gottschling J, Thiel W, Spinath FM. Zygosity Determination in Twin Studies: a Validation of Zygosity Questionnaires Using DNA in the German TwinLife Study. TwinLife Working Paper Series. Vol 01. Bielefeld: Project TwinLife "Genetic and social causes of life chances" (Universität Bielefeld / Universität des Saarlandes); 2017.
Lenau, F., Hahn, E., Peters, A. - L., Gottschling, J., Thiel, W., & Spinath, F. M. (2017). Zygosity Determination in Twin Studies: a Validation of Zygosity Questionnaires Using DNA in the German TwinLife Study (TwinLife Working Paper Series, 01). Bielefeld: Project TwinLife "Genetic and social causes of life chances" (Universität Bielefeld / Universität des Saarlandes).
Lenau, F., Hahn, E., Peters, A. - L., Gottschling, J., Thiel, W., and Spinath, F. M. (2017). Zygosity Determination in Twin Studies: a Validation of Zygosity Questionnaires Using DNA in the German TwinLife Study. TwinLife Working Paper Series, 01, Bielefeld: Project TwinLife "Genetic and social causes of life chances" (Universität Bielefeld / Universität des Saarlandes).
Lenau, F., et al., 2017. Zygosity Determination in Twin Studies: a Validation of Zygosity Questionnaires Using DNA in the German TwinLife Study, TwinLife Working Paper Series, no.01, Bielefeld: Project TwinLife "Genetic and social causes of life chances" (Universität Bielefeld / Universität des Saarlandes).
F. Lenau, et al., Zygosity Determination in Twin Studies: a Validation of Zygosity Questionnaires Using DNA in the German TwinLife Study, TwinLife Working Paper Series, vol. 01, Bielefeld: Project TwinLife "Genetic and social causes of life chances" (Universität Bielefeld / Universität des Saarlandes), 2017.
Lenau, F., Hahn, E., Peters, A.-L., Gottschling, J., Thiel, W., Spinath, F.M.: Zygosity Determination in Twin Studies: a Validation of Zygosity Questionnaires Using DNA in the German TwinLife Study. TwinLife Working Paper Series, 01. Project TwinLife "Genetic and social causes of life chances" (Universität Bielefeld / Universität des Saarlandes), Bielefeld (2017).
Lenau, Franziska, Hahn, Elisabeth, Peters, Anna-Lena, Gottschling, Juliana, Thiel, Wolfgang, and Spinath, Frank M. Zygosity Determination in Twin Studies: a Validation of Zygosity Questionnaires Using DNA in the German TwinLife Study. Bielefeld: Project TwinLife "Genetic and social causes of life chances" (Universität Bielefeld / Universität des Saarlandes), 2017. TwinLife Working Paper Series. 01.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Copyright Statement:
This Item is protected by copyright and/or related rights. [...]
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2017-04-12T09:40:17Z

Link(s) zu Volltext(en)
Access Level
OA Open Access

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Suchen in

Google Scholar