Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants

Biermann M, Bakonyi D, Hummel W, Gröger H (2017)
GREEN CHEMISTRY 19(2): 405-410.

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Abstract
Whole-cell catalysts overexpressing two enzymes for a double reduction cascade in which aliphatic alpha-branched alpha,beta-unsaturated aldehydes are converted into Guerbet alcohols as a highly demanded class of lubricants were constructed and characterized. The reaction conditions were optimized to suppress by-product formation, achieving high conversion and selectivity. Application of methanol as a co-solvent on a 500 mL scale enabled a substrate concentration of 18.5 g L-1 obtaining 97% yield and 88% purity without further distillation. Addressing the needs of industrial processes, substrate loading was increased up to 94 g L-1 and the E-factor (environmental factor) was significantly improved compared to the original process with isolated enzymes.
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Biermann M, Bakonyi D, Hummel W, Gröger H. Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants. GREEN CHEMISTRY. 2017;19(2):405-410.
Biermann, M., Bakonyi, D., Hummel, W., & Gröger, H. (2017). Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants. GREEN CHEMISTRY, 19(2), 405-410. doi:10.1039/c6gc01668e
Biermann, M., Bakonyi, D., Hummel, W., and Gröger, H. (2017). Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants. GREEN CHEMISTRY 19, 405-410.
Biermann, M., et al., 2017. Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants. GREEN CHEMISTRY, 19(2), p 405-410.
M. Biermann, et al., “Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants”, GREEN CHEMISTRY, vol. 19, 2017, pp. 405-410.
Biermann, M., Bakonyi, D., Hummel, W., Gröger, H.: Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants. GREEN CHEMISTRY. 19, 405-410 (2017).
Biermann, Marc, Bakonyi, Daniel, Hummel, Werner, and Gröger, Harald. “Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants”. GREEN CHEMISTRY 19.2 (2017): 405-410.
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