First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols

Rulli G, Duangdee N, Hummel W, Berkessel A, Gröger H (2017)
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2017(4): 812-817.

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Abstract
A suitable "process window" was identified for the combination of an asymmetric organocatalytic aldol reaction and subsequent biocatalytic reduction in aqueous medium, which thus enabled the enantio- and diastereoselective synthesis of 1,3-diols in a tandem-type, one-pot process. A key feature of this one-pot synthesis is the high 500 mM loading of the aldehyde substrate used as a starting material.
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Rulli G, Duangdee N, Hummel W, Berkessel A, Gröger H. First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2017;2017(4):812-817.
Rulli, G., Duangdee, N., Hummel, W., Berkessel, A., & Gröger, H. (2017). First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017(4), 812-817. doi:10.1002/ejoc.201600831
Rulli, G., Duangdee, N., Hummel, W., Berkessel, A., and Gröger, H. (2017). First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2017, 812-817.
Rulli, G., et al., 2017. First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017(4), p 812-817.
G. Rulli, et al., “First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols”, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2017, 2017, pp. 812-817.
Rulli, G., Duangdee, N., Hummel, W., Berkessel, A., Gröger, H.: First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2017, 812-817 (2017).
Rulli, Giuseppe, Duangdee, Nongnaphat, Hummel, Werner, Berkessel, Albrecht, and Gröger, Harald. “First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols”. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2017.4 (2017): 812-817.
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