New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp MP131-18

Paulus C, Rebets Y, Tokovenko B, Nadmid S, Terekhova LP, Myronovskyi M, Zotchev SB, Rückert C, Braig S, Zahler S, Kalinowski J, et al. (2017)
SCIENTIFIC REPORTS 7: 42382.

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Marine actinobacteria are drawing more and more attention as a promising source of new natural products. Here we report isolation, genome sequencing and metabolic profiling of new strain Streptomyces sp. MP131-18 isolated from marine sediment sample collected in the Trondheim Fjord, Norway. The 16S rRNA and multilocus phylogenetic analysis showed that MP131-18 belongs to the genus Streptomyces. The genome of MP131-18 isolate was sequenced, and 36 gene clusters involved in the biosynthesis of 18 different types of secondary metabolites were predicted using antiSMASH analysis. The combined genomics-metabolics profiling of the strain led to the identification of several new biologically active compounds. As a result, the family of bisindole pyrroles spiroindimicins was extended with two new members, spiroindimicins E and F. Furthermore, prediction of the biosynthetic pathway for unusual alpha-pyrone lagunapyrone isolated from MP131-18 resulted in foresight and identification of two new compounds of this family - lagunapyrones D and E. The diversity of identified and predicted compounds from Streptomyces sp. MP131-18 demonstrates that marine-derived actinomycetes are not only a promising source of new natural products, but also represent a valuable pool of genes for combinatorial biosynthesis of secondary metabolites.
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Paulus C, Rebets Y, Tokovenko B, et al. New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp MP131-18. SCIENTIFIC REPORTS. 2017;7: 42382.
Paulus, C., Rebets, Y., Tokovenko, B., Nadmid, S., Terekhova, L. P., Myronovskyi, M., Zotchev, S. B., et al. (2017). New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp MP131-18. SCIENTIFIC REPORTS, 7, 42382. doi:10.1038/srep42382
Paulus, C., Rebets, Y., Tokovenko, B., Nadmid, S., Terekhova, L. P., Myronovskyi, M., Zotchev, S. B., Rückert, C., Braig, S., Zahler, S., et al. (2017). New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp MP131-18. SCIENTIFIC REPORTS 7:42382.
Paulus, C., et al., 2017. New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp MP131-18. SCIENTIFIC REPORTS, 7: 42382.
C. Paulus, et al., “New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp MP131-18”, SCIENTIFIC REPORTS, vol. 7, 2017, : 42382.
Paulus, C., Rebets, Y., Tokovenko, B., Nadmid, S., Terekhova, L.P., Myronovskyi, M., Zotchev, S.B., Rückert, C., Braig, S., Zahler, S., Kalinowski, J., Luzhetskyy, A.: New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp MP131-18. SCIENTIFIC REPORTS. 7, : 42382 (2017).
Paulus, Constanze, Rebets, Yuriy, Tokovenko, Bogdan, Nadmid, Suvd, Terekhova, Larisa P., Myronovskyi, Maksym, Zotchev, Sergey B., Rückert, Christian, Braig, Simone, Zahler, Stefan, Kalinowski, Jörn, and Luzhetskyy, Andriy. “New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp MP131-18”. SCIENTIFIC REPORTS 7 (2017): 42382.
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