A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system

Lopes MW, Leal RB, Guarnieri R, Schwarzbold ML, Hoeller A, Diaz AP, Boos GL, Lin K, Linhares MN, Nunes JC, Quevedo J, et al. (2016)
TRANSLATIONAL PSYCHIATRY 6: e986.

Download
No fulltext has been uploaded. References only!
Journal Article | Original Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ; ; ; ; ;
All
Abstract
Glucocorticoids (GC) released during stress response exert feedforward effects in the whole brain, but particularly in the limbic circuits that modulates cognition, emotion and behavior. GC are the most commonly prescribed anti-inflammatory and immunosuppressant medication worldwide and pharmacological GC treatment has been paralleled by the high incidence of acute and chronic neuropsychiatric side effects, which reinforces the brain sensitivity for GC. Synapses can be bi-directionally modifiable via potentiation (long-term potentiation, LTP) or depotentiation (long-term depression, LTD) of synaptic transmission efficacy, and the phosphorylation state of Ser831 and Ser845 sites, in the GluA1 subunit of the glutamate AMPA receptors, are a critical event for these synaptic neuroplasticity events. Through a quasi-randomized controlled study, we show that a single high dexamethasone dose significantly reduces in a dose-dependent manner the levels of GluA1-Ser831 phosphorylation in the amygdala resected during surgery for temporal lobe epilepsy. This is the first report demonstrating GC effects on key markers of synaptic neuroplasticity in the human limbic system. The results contribute to understanding how GC affects the human brain under physiologic and pharmacologic conditions.
Publishing Year
ISSN
PUB-ID

Cite this

Lopes MW, Leal RB, Guarnieri R, et al. A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. TRANSLATIONAL PSYCHIATRY. 2016;6: e986.
Lopes, M. W., Leal, R. B., Guarnieri, R., Schwarzbold, M. L., Hoeller, A., Diaz, A. P., Boos, G. L., et al. (2016). A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. TRANSLATIONAL PSYCHIATRY, 6, e986. doi:10.1038/tp.2016.251
Lopes, M. W., Leal, R. B., Guarnieri, R., Schwarzbold, M. L., Hoeller, A., Diaz, A. P., Boos, G. L., Lin, K., Linhares, M. N., Nunes, J. C., et al. (2016). A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. TRANSLATIONAL PSYCHIATRY 6:e986.
Lopes, M.W., et al., 2016. A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. TRANSLATIONAL PSYCHIATRY, 6: e986.
M.W. Lopes, et al., “A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system”, TRANSLATIONAL PSYCHIATRY, vol. 6, 2016, : e986.
Lopes, M.W., Leal, R.B., Guarnieri, R., Schwarzbold, M.L., Hoeller, A., Diaz, A.P., Boos, G.L., Lin, K., Linhares, M.N., Nunes, J.C., Quevedo, J., Bortolotto, Z.A., Markowitsch, H.J., Lightman, S.L., Walz, R.: A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. TRANSLATIONAL PSYCHIATRY. 6, : e986 (2016).
Lopes, M. W., Leal, R. B., Guarnieri, R., Schwarzbold, M. L., Hoeller, A., Diaz, A. P., Boos, G. L., Lin, K., Linhares, M. N., Nunes, J. C., Quevedo, J., Bortolotto, Z. A., Markowitsch, Hans J., Lightman, S. L., and Walz, R. “A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system”. TRANSLATIONAL PSYCHIATRY 6 (2016): e986.
This data publication is cited in the following publications:
This publication cites the following data publications:

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 27959333
PubMed | Europe PMC

Search this title in

Google Scholar