Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase

Dhamale OP, Lawrence R, Wiegmann E, Shah BA, Al-Mafraji K, Lamanna WC, Lübke T, Dierks T, Boons G-J, Esko JD (2017)
ACS Chemical Biology 12(2): 367-373.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ; ; ; ; ; ;
Abstract / Bemerkung
The degradation of glycosaminoglycans (GAGs) involves a series of exolytic glycosidases and sulfatases that act sequentially on the nonreducing end of the polysaccharide chain. Enzymes have been cloned that catalyze all of the known linkages with the exception of the removal of the 2-O-sulfate group from 2-sulfoglucuronate, which is found in heparan sulfate and dermatan sulfate. Here, we show using synthetic disaccharide substrates that arylsulfatase K is the glucuronate-2-sulfatase. Arylsulfatase K acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate, whereas iduronate-2-sulfatase (IDS) desulfates synthetic disaccharides containing 2-sulfoiduronate but not 2-sulfoglucuronate. As arylsulfatase K has all of the properties expected of a lysosomal enzyme, we conclude that arylsulfatase K is the long sought lysosomal glucuronate-2-sulfatase, which we designate GDS.
Erscheinungsjahr
Zeitschriftentitel
ACS Chemical Biology
Band
12
Ausgabe
2
Seite(n)
367-373
ISSN
PUB-ID

Zitieren

Dhamale OP, Lawrence R, Wiegmann E, et al. Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase. ACS Chemical Biology. 2017;12(2):367-373.
Dhamale, O. P., Lawrence, R., Wiegmann, E., Shah, B. A., Al-Mafraji, K., Lamanna, W. C., Lübke, T., et al. (2017). Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase. ACS Chemical Biology, 12(2), 367-373. doi:10.1021/acschembio.6b01033
Dhamale, O. P., Lawrence, R., Wiegmann, E., Shah, B. A., Al-Mafraji, K., Lamanna, W. C., Lübke, T., Dierks, T., Boons, G. - J., and Esko, J. D. (2017). Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase. ACS Chemical Biology 12, 367-373.
Dhamale, O.P., et al., 2017. Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase. ACS Chemical Biology, 12(2), p 367-373.
O.P. Dhamale, et al., “Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase”, ACS Chemical Biology, vol. 12, 2017, pp. 367-373.
Dhamale, O.P., Lawrence, R., Wiegmann, E., Shah, B.A., Al-Mafraji, K., Lamanna, W.C., Lübke, T., Dierks, T., Boons, G.-J., Esko, J.D.: Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase. ACS Chemical Biology. 12, 367-373 (2017).
Dhamale, Omkar P., Lawrence, Roger, Wiegmann, Elena, Shah, Bhawal A., Al-Mafraji, Kanar, Lamanna, William C., Lübke, Torben, Dierks, Thomas, Boons, Geert-Jan, and Esko, Jeffrey D. “Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase”. ACS Chemical Biology 12.2 (2017): 367-373.

27 References

Daten bereitgestellt von Europe PubMed Central.

Order out of chaos: assembly of ligand binding sites in heparan sulfate.
Esko JD, Selleck SB., Annu. Rev. Biochem. 71(), 2001
PMID: 12045103
Demystifying heparan sulfate-protein interactions.
Xu D, Esko JD., Annu. Rev. Biochem. 83(), 2014
PMID: 24606135
The molecular diversity of glycosaminoglycans shapes animal development.
Bulow HE, Hobert O., Annu. Rev. Cell Dev. Biol. 22(), 2006
PMID: 16805665
Heparan sulphate proteoglycans fine-tune mammalian physiology.
Bishop JR, Schuksz M, Esko JD., Nature 446(7139), 2007
PMID: 17460664
Glycan-based biomarkers for mucopolysaccharidoses.
Lawrence R, Brown JR, Lorey F, Dickson PI, Crawford BE, Esko JD., Mol. Genet. Metab. 111(2), 2013
PMID: 23958290
From bedside to cell biology: a century of history on lysosomal dysfunction.
Coutinho MF, Matos L, Alves S., Gene 555(1), 2014
PMID: 25275857
Inherited disorders of lysosomal metabolism.
Neufeld EF, Lim TW, Shapiro LJ., Annu. Rev. Biochem. 44(), 1975
PMID: 806251
The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases.
Cosma MP, Pepe S, Annunziata I, Newbold RF, Grompe M, Parenti G, Ballabio A., Cell 113(4), 2003
PMID: 12757706
Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme.
Dierks T, Schmidt B, Borissenko LV, Peng J, Preusser A, Mariappan M, von Figura K., Cell 113(4), 2003
PMID: 12757705
A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency.
Schmidt B, Selmer T, Ingendoh A, von Figura K., Cell 82(2), 1995
PMID: 7628016
Sulfatases: Structure, Mechanism, Biological Activity, Inhibition, and Synthetic Utility
Hanson SR, Best MD, Wong CH., 2004
Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship.
Sardiello M, Annunziata I, Roma G, Ballabio A., Hum. Mol. Genet. 14(21), 2005
PMID: 16174644
Arylsulfatase G, a novel lysosomal sulfatase.
Frese MA, Schulz S, Dierks T., J. Biol. Chem. 283(17), 2008
PMID: 18283100
Arylsulfatase K, a novel lysosomal sulfatase.
Wiegmann EM, Westendorf E, Kalus I, Pringle TH, Lubke T, Dierks T., J. Biol. Chem. 288(42), 2013
PMID: 23986440
Ataxia is the major neuropathological finding in arylsulfatase G-deficient mice: similarities and dissimilarities to Sanfilippo disease (mucopolysaccharidosis type III).
Kowalewski B, Heimann P, Ortkras T, Lullmann-Rauch R, Sawada T, Walkley SU, Dierks T, Damme M., Hum. Mol. Genet. 24(7), 2014
PMID: 25452429
Molecular characterization of arylsulfatase G: expression, processing, glycosylation, transport, and activity.
Kowalewski B, Lubke T, Kollmann K, Braulke T, Reinheckel T, Dierks T, Damme M., J. Biol. Chem. 289(40), 2014
PMID: 25135642
Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice.
Kowalewski B, Lamanna WC, Lawrence R, Damme M, Stroobants S, Padva M, Kalus I, Frese MA, Lubke T, Lullmann-Rauch R, D'Hooge R, Esko JD, Dierks T., Proc. Natl. Acad. Sci. U.S.A. 109(26), 2012
PMID: 22689975
Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses.
Lawrence R, Brown JR, Al-Mafraji K, Lamanna WC, Beitel JR, Boons GJ, Esko JD, Crawford BE., Nat. Chem. Biol. 8(2), 2012
PMID: 22231271
Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies.
Arungundram S, Al-Mafraji K, Asong J, Leach FE 3rd, Amster IJ, Venot A, Turnbull JE, Boons GJ., J. Am. Chem. Soc. 131(47), 2009
PMID: 19904943
Evolutionary differences in glycosaminoglycan fine structure detected by quantitative glycan reductive isotope labeling.
Lawrence R, Olson SK, Steele RE, Wang L, Warrior R, Cummings RD, Esko JD., J. Biol. Chem. 283(48), 2008
PMID: 18818196
A sulfatase specific for glucuronic acid 2-sulfate residues in glycosaminoglycans.
Shaklee PN, Glaser JH, Conrad HE., J. Biol. Chem. 260(16), 1985
PMID: 4019466
Glucuronate-2-sulphatase activity in cultured human skin fibroblast homogenates.
Freeman C, Hopwood JJ., Biochem. J. 279 ( Pt 2)(), 1991
PMID: 1953637
Structure of disulfated disaccharides from chondroitin polysulfates, chondroitin sulfate D and K
Send N, Murakami K., 1982
Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycans.
Lawrence R, Lu H, Rosenberg RD, Esko JD, Zhang L., Nat. Methods 5(4), 2008
PMID: 18376390

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 28055182
PubMed | Europe PMC

Suchen in

Google Scholar