Rare event simulation in immune biology: Models of negative selection in T-cell maturation

Ernst C, Baake E (2014)
arXiv:1407.5503.

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We present a probabilistic T-cell model that includes negative selection and takes contrasting models of tissue-restricted antigen (TRA) expression in the thymus into account. We start from the basic model of van den Berg, Rand, and Burroughs (2001) and include negative selection via individual-based T-cell modelling, in which each T-cell is defined by its stimulation rates to all relevant self antigens. We present a simulation approach based on partial tilting of the stimulation rates recognized by a single T-cell. We investigate the effects of negative selection for diverging modes of thymic antigen presentation, namely arbitrary TRA presentation, and more or less strict emulation of tissue-specific cell lines. We observe that negative selection leads to truncation of the tail of the distribution of the stimulation rates mature T-cells receive from self antigens, i.e., the self background is reduced. This increases the activation probabilities of single T-cells in the presence of non-self antigens.
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Ernst C, Baake E. Rare event simulation in immune biology: Models of negative selection in T-cell maturation. arXiv:1407.5503. 2014.
Ernst, C., & Baake, E. (2014). Rare event simulation in immune biology: Models of negative selection in T-cell maturation. arXiv:1407.5503
Ernst, C., and Baake, E. (2014). Rare event simulation in immune biology: Models of negative selection in T-cell maturation. arXiv:1407.5503.
Ernst, C., & Baake, E., 2014. Rare event simulation in immune biology: Models of negative selection in T-cell maturation. arXiv:1407.5503.
C. Ernst and E. Baake, “Rare event simulation in immune biology: Models of negative selection in T-cell maturation”, arXiv:1407.5503, 2014.
Ernst, C., Baake, E.: Rare event simulation in immune biology: Models of negative selection in T-cell maturation. arXiv:1407.5503. (2014).
Ernst, Corinna, and Baake, Ellen. “Rare event simulation in immune biology: Models of negative selection in T-cell maturation”. arXiv:1407.5503 (2014).
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