Assembling the microbial dark matter

Bremges A (2016)
Bielefeld: Universität Bielefeld.

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Bielefeld Dissertation | English
Abstract
The vast majority of microbial species found in nature has yet to be grown in pure culture, turning metagenomics and – more recently – single cell genomics into indispensable methods to study the microbial dark matter.

I developed, applied, and benchmarked genome assembly protocols for single cell and metagenome sequencing data to access microbial dark matter genomes.

In the first part of my thesis, I propose new algorithms that naturally exploit the complementary nature of single cells and metagenomes to improve the quality of single cell assemblies.

In the second part, I apply advanced metagenome assembly and binning techniques to untangle genomes from metagenomes, eventually reconstructing hundreds of near-complete genomes of process-relevant community members in the biogas microbiome.
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Bremges A. Assembling the microbial dark matter. Bielefeld: Universität Bielefeld; 2016.
Bremges, A. (2016). Assembling the microbial dark matter. Bielefeld: Universität Bielefeld.
Bremges, A. (2016). Assembling the microbial dark matter. Bielefeld: Universität Bielefeld.
Bremges, A., 2016. Assembling the microbial dark matter, Bielefeld: Universität Bielefeld.
A. Bremges, Assembling the microbial dark matter, Bielefeld: Universität Bielefeld, 2016.
Bremges, A.: Assembling the microbial dark matter. Universität Bielefeld, Bielefeld (2016).
Bremges, Andreas. Assembling the microbial dark matter. Bielefeld: Universität Bielefeld, 2016.
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