Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (< 250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry

Giampa M, Lissel M, Patschkowski T, Fuchser J, Hans VH, Gembruch O, Bednarz H, Niehaus K (2016)
Chemical Communications 52(63): 9801-9804.

Journal Article | Published | English

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Abstract
A novel vacuum stable proton sponge, 4-maleicanhydridoproton sponge (MAPS), was prepared and applied as the matrix in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) of an aggressive brain tumor tissue (glioblastoma multiforme). Ionic maps of lactate, 2-hydroxyglutarate and chloride anions (m/z 89, 147, 35, respectively) were obtained using a routine MALDI ToF mass spectrometer.
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Giampa M, Lissel M, Patschkowski T, et al. Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (< 250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry. Chemical Communications. 2016;52(63):9801-9804.
Giampa, M., Lissel, M., Patschkowski, T., Fuchser, J., Hans, V. H., Gembruch, O., Bednarz, H., et al. (2016). Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (< 250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry. Chemical Communications, 52(63), 9801-9804.
Giampa, M., Lissel, M., Patschkowski, T., Fuchser, J., Hans, V. H., Gembruch, O., Bednarz, H., and Niehaus, K. (2016). Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (< 250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry. Chemical Communications 52, 9801-9804.
Giampa, M., et al., 2016. Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (< 250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry. Chemical Communications, 52(63), p 9801-9804.
M. Giampa, et al., “Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (< 250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry”, Chemical Communications, vol. 52, 2016, pp. 9801-9804.
Giampa, M., Lissel, M., Patschkowski, T., Fuchser, J., Hans, V.H., Gembruch, O., Bednarz, H., Niehaus, K.: Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (< 250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry. Chemical Communications. 52, 9801-9804 (2016).
Giampa, Marco, Lissel, Manfred, Patschkowski, Thomas, Fuchser, J., Hans, V. H., Gembruch, O., Bednarz, Hanna, and Niehaus, Karsten. “Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (< 250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry”. Chemical Communications 52.63 (2016): 9801-9804.
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