Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial

Klein JP, Berger T, Schroeder J, Spaeth C, Meyer B, Caspar F, Lutz W, Arndt A, Greiner W, Gräfe V, Hautzinger M, et al. (2016)
Psychotherapy and Psychosomatics 85(4): 218-228.

Download
No fulltext has been uploaded. References only!
Journal Article | Original Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ; ; ; ; ;
All
Abstract
Background: Mild to moderate depressive symptoms are common but often remain unrecognized and treated inadequately. We hypothesized that an Internet intervention in addition to usual care is superior to care as usual alone (CAU) in the treatment of mild to moderate depressive symptoms in adults. Methods: This trial was controlled, randomized and assessor-blinded. Participants with mild to moderate depressive symptoms (Patient Health Questionnaire, PHQ-9, score 5-14) were recruited from clinical and non-clinical set-tings and randomized to either CAU or a 12-week Internet intervention (Deprexis) adjunctive to usual care. Outcomes were assessed at baseline, 3 months (post-assessment) and 6 months (follow-up). The primary outcome measure was self-rated depression severity (PHQ-9). The main analysis was based on the intention-to-treat principle and used linear mixed models. Results: A total of 1,013 participants were randomized. Changes in PHQ-9 from baseline differed significantly between groups (t(825) = 6.12, p < 0.001 for the main effect of group). The post-assessment between-group effect size in favour of the intervention was d = 0.39 (95% CI: 0.13-0.64). It was stable at follow-up, with d = 0.32 (95% CI: 0.06-0.69). The rate of participants experiencing at least minimally clinically important PHQ-9 change at the post-assessment was higher in the intervention group (35.6 vs. 20.2%) with a number needed to treat of 7 (95% CI: 5-10). Conclusions: The Internet intervention examined in this trial was superior to CAU alone in reducing mild to moderate depressive symptoms. The magnitude of the effect is clinically important and has public health implications. (C) 2016 S. Karger AG, Basel
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Klein JP, Berger T, Schroeder J, et al. Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial. Psychotherapy and Psychosomatics. 2016;85(4):218-228.
Klein, J. P., Berger, T., Schroeder, J., Spaeth, C., Meyer, B., Caspar, F., Lutz, W., et al. (2016). Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial. Psychotherapy and Psychosomatics, 85(4), 218-228. doi:10.1159/000445355
Klein, J. P., Berger, T., Schroeder, J., Spaeth, C., Meyer, B., Caspar, F., Lutz, W., Arndt, A., Greiner, W., Gräfe, V., et al. (2016). Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial. Psychotherapy and Psychosomatics 85, 218-228.
Klein, J.P., et al., 2016. Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial. Psychotherapy and Psychosomatics, 85(4), p 218-228.
J.P. Klein, et al., “Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial”, Psychotherapy and Psychosomatics, vol. 85, 2016, pp. 218-228.
Klein, J.P., Berger, T., Schroeder, J., Spaeth, C., Meyer, B., Caspar, F., Lutz, W., Arndt, A., Greiner, W., Gräfe, V., Hautzinger, M., Fuhr, K., Rose, M., Nolte, S., Loewe, B., Andersson, G., Vettorazzi, E., Moritz, S., Hohagen, F.: Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial. Psychotherapy and Psychosomatics. 85, 218-228 (2016).
Klein, Jan Philipp, Berger, Thomas, Schroeder, Johanna, Spaeth, Christina, Meyer, Bjoern, Caspar, Franz, Lutz, Wolfgang, Arndt, Alice, Greiner, Wolfgang, Gräfe, Viola, Hautzinger, Martin, Fuhr, Kristina, Rose, Matthias, Nolte, Sandra, Loewe, Bernd, Andersson, Gerhard, Vettorazzi, Eik, Moritz, Steffen, and Hohagen, Fritz. “Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial”. Psychotherapy and Psychosomatics 85.4 (2016): 218-228.
This data publication is cited in the following publications:
This publication cites the following data publications:

14 Citations in Europe PMC

Data provided by Europe PubMed Central.

[Can online therapy meaningfully complement psychotherapy? Pro].
Hautzinger M, Fuhr K., Nervenarzt 89(1), 2018
PMID: 28776211
Benefits of Individualized Feedback in Internet-Based Interventions for Depression: A Randomized Controlled Trial.
Zagorscak P, Heinrich M, Sommer D, Wagner B, Knaevelsrud C., Psychother Psychosom 87(1), 2018
PMID: 29306945
A patient post hoc perspective on advantages and disadvantages of blended cognitive behaviour therapy for depression: A qualitative content analysis.
Urech A, Krieger T, Möseneder L, Biaggi A, Vincent A, Poppe C, Meyer B, Riper H, Berger T., Psychother Res (), 2018
PMID: 29385964
Impact and change of attitudes toward Internet interventions within a randomized controlled trial on individuals with depression symptoms.
Schröder J, Berger T, Meyer B, Lutz W, Späth C, Michel P, Rose M, Hautzinger M, Hohagen F, Klein JP, Moritz S., Depress Anxiety (), 2018
PMID: 29489038
Is self-guided internet-based cognitive behavioural therapy (iCBT) harmful? An individual participant data meta-analysis.
Karyotaki E, Kemmeren L, Riper H, Twisk J, Hoogendoorn A, Kleiboer A, Mira A, Mackinnon A, Meyer B, Botella C, Littlewood E, Andersson G, Christensen H, Klein JP, Schröder J, Bretón-López J, Scheider J, Griffiths K, Farrer L, Huibers MJH, Phillips R, Gilbody S, Moritz S, Berger T, Pop V, Spek V, Cuijpers P., Psychol Med (), 2018
PMID: 29540243
Effects of a transdiagnostic unguided Internet intervention ('velibra') for anxiety disorders in primary care: results of a randomized controlled trial.
Berger T, Urech A, Krieger T, Stolz T, Schulz A, Vincent A, Moser CT, Moritz S, Meyer B., Psychol Med 47(1), 2017
PMID: 27655039
The regression discontinuity design showed to be a valid alternative to a randomized controlled trial for estimating treatment effects.
Maas IL, Nolte S, Walter OB, Berger T, Hautzinger M, Hohagen F, Lutz W, Meyer B, Schröder J, Späth C, Klein JP, Moritz S, Rose M., J Clin Epidemiol 82(), 2017
PMID: 27865902
Protocol for the ENCODE trial: evaluating a novel online depression intervention for persons with epilepsy.
Meyer B, Weiss M, Holtkamp M, Arnold S, Brückner K, Schröder J, Scheibe F, Nestoriuc Y., BMC Psychiatry 17(1), 2017
PMID: 28173780
Defining and Predicting Patterns of Early Response in a Web-Based Intervention for Depression.
Lutz W, Arndt A, Rubel J, Berger T, Schröder J, Späth C, Meyer B, Greiner W, Gräfe V, Hautzinger M, Fuhr K, Rose M, Nolte S, Löwe B, Hohagen F, Klein JP, Moritz S., J Med Internet Res 19(6), 2017
PMID: 28600278
Does recruitment source moderate treatment effectiveness? A subgroup analysis from the EVIDENT study, a randomised controlled trial of an internet intervention for depressive symptoms.
Klein JP, Gamon C, Späth C, Berger T, Meyer B, Hohagen F, Hautzinger M, Lutz W, Vettorazzi E, Moritz S, Schröder J., BMJ Open 7(7), 2017
PMID: 28710212
Online Self-Help as an Add-On to Inpatient Psychotherapy: Efficacy of a New Blended Treatment Approach.
Zwerenz R, Becker J, Knickenberg RJ, Siepmann M, Hagen K, Beutel ME., Psychother Psychosom 86(6), 2017
PMID: 29131090

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 27230863
PubMed | Europe PMC

Search this title in

Google Scholar