Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Jelenkovic A, Sund R, Hur Y-M, Yokoyama Y, Hjelmborg JVB, Moller S, Honda C, Magnusson PKE, Pedersen NL, Ooki S, Aaltonen S, et al. (2016)
SCIENTIFIC REPORTS 6: 28496.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.
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SCIENTIFIC REPORTS
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6
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28496
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Jelenkovic A, Sund R, Hur Y-M, et al. Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. SCIENTIFIC REPORTS. 2016;6: 28496.
Jelenkovic, A., Sund, R., Hur, Y. - M., Yokoyama, Y., Hjelmborg, J. V. B., Moller, S., Honda, C., et al. (2016). Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. SCIENTIFIC REPORTS, 6, 28496. doi:10.1038/srep28496
Jelenkovic, A., Sund, R., Hur, Y. - M., Yokoyama, Y., Hjelmborg, J. V. B., Moller, S., Honda, C., Magnusson, P. K. E., Pedersen, N. L., Ooki, S., et al. (2016). Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. SCIENTIFIC REPORTS 6:28496.
Jelenkovic, A., et al., 2016. Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. SCIENTIFIC REPORTS, 6: 28496.
A. Jelenkovic, et al., “Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts”, SCIENTIFIC REPORTS, vol. 6, 2016, : 28496.
Jelenkovic, A., Sund, R., Hur, Y.-M., Yokoyama, Y., Hjelmborg, J.V.B., Moller, S., Honda, C., Magnusson, P.K.E., Pedersen, N.L., Ooki, S., Aaltonen, S., Stazi, M.A., Fagnani, C., D'Ippolito, C., Freitas, D.L., Maia, J.A., Ji, F., Ning, F., Pang, Z., Rebato, E., Busjahn, A., Kandler, C., Saudino, K.J., Jang, K.L., Cozen, W., Hwang, A.E., Mack, T.M., Gao, W., Yu, C., Li, L., Corley, R.P., Huibregtse, B.M., Derom, C.A., Vlietinck, R.F., Loos, R.J.F., Heikkila, K., Wardle, J., Llewellyn, C.H., Fisher, A., McAdams, T.A., Eley, T.C., Gregory, A.M., He, M., Ding, X., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Tarnoki, A.D., Tarnoki, D.L., Knafo-Noam, A., Mankuta, D., Abramson, L., Burt, S.A., Klump, K.L., Silberg, J.L., Eaves, L.J., Maes, H.H., Krueger, R.F., McGue, M., Pahlen, S., Gatz, M., Butler, D.A., Bartels, M., van Beijsterveldt, T.C.E.M., Craig, J.M., Saffery, R., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Martin, N.G., Medland, S.E., Montgomery, G.W., Swan, G.E., Krasnow, R., Tynelius, P., Lichtenstein, P., Haworth, C.M.A., Plomin, R., Bayasgalan, G., Narandalai, D., Harden, K.P., Tucker-Drob, E.M., Spector, T., Mangino, M., Lachance, G., Baker, L.A., Tuvblad, C., Duncan, G.E., Buchwald, D., Willemsen, G., Skytthe, A., Kyvik, K.O., Christensen, K., Oncel, S.Y., Aliev, F., Rasmussen, F., Goldberg, J.H., Sorensen, T.I.A., Boomsma, D.I., Kaprio, J., Silventoinen, K.: Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. SCIENTIFIC REPORTS. 6, : 28496 (2016).
Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob V. B., Moller, Soren, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, Jose Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Swan, Gary E., Krasnow, Ruth, Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Skytthe, Axel, Kyvik, Kirsten O., Christensen, Kaare, Oncel, Sevgi Y., Aliev, Fazil, Rasmussen, Finn, Goldberg, Jack H., Sorensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, and Silventoinen, Karri. “Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts”. SCIENTIFIC REPORTS 6 (2016): 28496.

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Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994.
Jelenkovic A, Hur YM, Sund R, Yokoyama Y, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Tan Q, Zhang D, Pang Z, Aaltonen S, Heikkilä K, Öncel SY, Aliev F, Rebato E, Tarnoki AD, Tarnoki DL, Christensen K, Skytthe A, Kyvik KO, Silberg JL, Eaves LJ, Maes HH, Cutler TL, Hopper JL, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Cozen W, Hwang AE, Mack TM, Sung J, Song YM, Yang S, Lee K, Franz CE, Kremen WS, Lyons MJ, Busjahn A, Nelson TL, Whitfield KE, Kandler C, Jang KL, Gatz M, Butler DA, Stazi MA, Fagnani C, D'Ippolito C, Duncan GE, Buchwald D, Derom CA, Vlietinck RF, Loos RJ, Martin NG, Medland SE, Montgomery GW, Jeong HU, Swan GE, Krasnow R, Magnusson PK, Pedersen NL, Dahl-Aslan AK, McAdams TA, Eley TC, Gregory AM, Tynelius P, Baker LA, Tuvblad C, Bayasgalan G, Narandalai D, Lichtenstein P, Spector TD, Mangino M, Lachance G, Bartels M, van Beijsterveldt TC, Willemsen G, Burt SA, Klump KL, Harris JR, Brandt I, Nilsen TS, Krueger RF, McGue M, Pahlen S, Corley RP, Hjelmborg JV, Goldberg JH, Iwatani Y, Watanabe M, Honda C, Inui F, Rasmussen F, Huibregtse BM, Boomsma DI, Sørensen TI, Kaprio J, Silventoinen K., Elife 5(), 2016
PMID: 27964777

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