Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae)

Razakarivony AA, Lenta Ndjakou B, Andriamihaja B, Michalek C, Razanamahefa B, Razafimahefa DR, Rakotondramanga MF, Randrianasolo R, Lannang AM, Randriamiaramisaina R, Boyom FF, et al. (2016)
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES 71(4): 297-303.

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Abstract
A new gentisic acid derivative named micronyc acid (1) and a new 1,4-benzoquinone derivative named micronone (2) have been isolated from the root of Micronychia tsiramiramy together with the known compounds gallic acid (3), methyl gallate (4), moronic acid (5), masticadienolic acid (6), and masticadienediol (7). The structures of 1 and 2 were established using MS and NMR. Compound 1 was tested for antiplasmodial activity in vitro against the chloroquine-resistant strain Plasmodium falciparum W2 and displayed moderate antiplasmodial activity in vitro with an IC50 value of 25.6 mu m. Compounds 1 and its acetyl derivative 1a were also tested for their cytotoxicity against the human cervix carcinoma cell line KB-3-1 and still showed moderate activity.
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Razakarivony AA, Lenta Ndjakou B, Andriamihaja B, et al. Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae). ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES. 2016;71(4):297-303.
Razakarivony, A. A., Lenta Ndjakou, B., Andriamihaja, B., Michalek, C., Razanamahefa, B., Razafimahefa, D. R., Rakotondramanga, M. F., et al. (2016). Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae). ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 71(4), 297-303.
Razakarivony, A. A., Lenta Ndjakou, B., Andriamihaja, B., Michalek, C., Razanamahefa, B., Razafimahefa, D. R., Rakotondramanga, M. F., Randrianasolo, R., Lannang, A. M., Randriamiaramisaina, R., et al. (2016). Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae). ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES 71, 297-303.
Razakarivony, A.A., et al., 2016. Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae). ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 71(4), p 297-303.
A.A. Razakarivony, et al., “Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae)”, ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, vol. 71, 2016, pp. 297-303.
Razakarivony, A.A., Lenta Ndjakou, B., Andriamihaja, B., Michalek, C., Razanamahefa, B., Razafimahefa, D.R., Rakotondramanga, M.F., Randrianasolo, R., Lannang, A.M., Randriamiaramisaina, R., Boyom, F.F., Rosenthal, P.J., Sewald, N.: Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae). ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES. 71, 297-303 (2016).
Razakarivony, Andrianambinina A., Lenta Ndjakou, Bruno, Andriamihaja, Bakolinirina, Michalek, Carmela, Razanamahefa, Bakonirina, Razafimahefa, Dorothee R., Rakotondramanga, Maonja Finaritra, Randrianasolo, Rivoarison, Lannang, Alain Meli, Randriamiaramisaina, Ralinandrianina, Boyom, Fekam F., Rosenthal, Philip J., and Sewald, Norbert. “Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae)”. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES 71.4 (2016): 297-303.
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