Cytotoxic 24-nor-ursane-type triterpenoids from the twigs of Mostuea hirsuta

Ekon JPL, Bissoue AN, Fomani M, Toze FAA, Kamdem AFW, Sewald N, Wansi J (2015)
Zeitschrift für Naturforschung Section B-A Journal of Chemical Sciences 70(11): 837-842.

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Abstract
Two new 24-nor-ursane-type triterpenoids, 2 alpha, 3 beta, 19 alpha-trihydroxy-24-norurs-4(23), 12-dien-28-oic acid (1) and 3 beta-acetoxy-2 alpha, 19 alpha-dihydroxy-24-norurs-4(23), 12-dien-28-oic acid (2), along with 15 known compounds were isolated from the methanol extract of the twigs of Mostuea hirsuta. While 2-hydroxymethylbenzamide (13) was isolated for the first time from the natural source, compounds 3-12 are reported here for the first time from the genus Mostuea. Their structures were elucidated by means of spectroscopic analyses including 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometric data as well as comparison with data from the literature. Compounds 1, 2, 4-9 and 13 were tested against bacteria, fungi and plant pathogen oomycetes by the paper disk agar diffusion assay resulting in missing to low activities corresponding with minimum inhibitory concentrations (MICs) > 1 mg mL(-1). However, the respective compounds 1, 2, 8, 9 and 13 exhibited moderate cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3, with IC50 10.6-16.5 mu m compared to the standard doxorubicin with IC50 0.9 mu m.
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Ekon JPL, Bissoue AN, Fomani M, et al. Cytotoxic 24-nor-ursane-type triterpenoids from the twigs of Mostuea hirsuta. Zeitschrift für Naturforschung Section B-A Journal of Chemical Sciences. 2015;70(11):837-842.
Ekon, J. P. L., Bissoue, A. N., Fomani, M., Toze, F. A. A., Kamdem, A. F. W., Sewald, N., & Wansi, J. (2015). Cytotoxic 24-nor-ursane-type triterpenoids from the twigs of Mostuea hirsuta. Zeitschrift für Naturforschung Section B-A Journal of Chemical Sciences, 70(11), 837-842.
Ekon, J. P. L., Bissoue, A. N., Fomani, M., Toze, F. A. A., Kamdem, A. F. W., Sewald, N., and Wansi, J. (2015). Cytotoxic 24-nor-ursane-type triterpenoids from the twigs of Mostuea hirsuta. Zeitschrift für Naturforschung Section B-A Journal of Chemical Sciences 70, 837-842.
Ekon, J.P.L., et al., 2015. Cytotoxic 24-nor-ursane-type triterpenoids from the twigs of Mostuea hirsuta. Zeitschrift für Naturforschung Section B-A Journal of Chemical Sciences, 70(11), p 837-842.
J.P.L. Ekon, et al., “Cytotoxic 24-nor-ursane-type triterpenoids from the twigs of Mostuea hirsuta”, Zeitschrift für Naturforschung Section B-A Journal of Chemical Sciences, vol. 70, 2015, pp. 837-842.
Ekon, J.P.L., Bissoue, A.N., Fomani, M., Toze, F.A.A., Kamdem, A.F.W., Sewald, N., Wansi, J.: Cytotoxic 24-nor-ursane-type triterpenoids from the twigs of Mostuea hirsuta. Zeitschrift für Naturforschung Section B-A Journal of Chemical Sciences. 70, 837-842 (2015).
Ekon, Jean Pierre Longue, Bissoue, Achille Nouga, Fomani, Marie, Toze, Flavien Aristide Alfred, Kamdem, Alain Francois Waffo, Sewald, Norbert, and Wansi, Jean. “Cytotoxic 24-nor-ursane-type triterpenoids from the twigs of Mostuea hirsuta”. Zeitschrift für Naturforschung Section B-A Journal of Chemical Sciences 70.11 (2015): 837-842.
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