Anti-inflammatory activity of benzophenone and xanthone derivatives isolated from Garcinia (Clusiaceae) species

Dzoyem JP, Lannang AM, Fouotsa H, Mbazoa CD, Nkengfack AE, Sewald N, Eloff JN (2015)
Phytochemistry Letters 14: 153-158.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Species of the genus Garcinia have been the source of many benzophenone and xanthone derivatives. Recent data regarding potent biological properties of natural compounds in Garcinia species led us to investigate the in vitro anti-inflammatory effect of three known xanthones, lichexanthone (1), 1,3,6,7-tetrahydroxyxanthone (2), 1,3,5,6-tetrahydroxyxanthone (3), two new xanthones 1-hydroxy-3,6,7-tri-O, O, O-triprenylxanthone (4), 1,6-dihydroxy-3,7-di-O, O-diprenylxanthone (5) and two benzophenones isoxanthochymol (6), guttiferone E (7), isolated from Garcinia nobilis and Garcinia punctata. The Griess assay was used for the measurement of nitric oxide (NO) production in RAW264.7 macrophages and the ferrous oxidation-xylenol orange assay was used to determine the 15-lipoxygenase (15-LOX) inhibitory activity. All the compounds had inhibitory effect on 15-LOX activity to different extents. Compound (7) had the highest anti-LOX activity with an IC50 value of 43.05 mu g/mL. At the highest studied concentration (25 mg/mL), compound (4) had the most potent inhibitory activity against NO release with a% of inhibition of 95.42% and less cytotoxic effect on RAW264.7 cells (% of cell viability of 81.40). The results presented here suggest that 1,3,5,6-tetrahydroxyxanthone (3) and guttiferone E (7) are promising inhibitors of NO production and 15-LOX activity. Further studies should be considered in order to elucidate the mechanism by which these compounds exert their inhibitory activities. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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Zeitschriftentitel
Phytochemistry Letters
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14
Seite
153-158
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Dzoyem JP, Lannang AM, Fouotsa H, et al. Anti-inflammatory activity of benzophenone and xanthone derivatives isolated from Garcinia (Clusiaceae) species. Phytochemistry Letters. 2015;14:153-158.
Dzoyem, J. P., Lannang, A. M., Fouotsa, H., Mbazoa, C. D., Nkengfack, A. E., Sewald, N., & Eloff, J. N. (2015). Anti-inflammatory activity of benzophenone and xanthone derivatives isolated from Garcinia (Clusiaceae) species. Phytochemistry Letters, 14, 153-158. doi:10.1016/j.phytol.2015.10.003
Dzoyem, J. P., Lannang, A. M., Fouotsa, H., Mbazoa, C. D., Nkengfack, A. E., Sewald, N., and Eloff, J. N. (2015). Anti-inflammatory activity of benzophenone and xanthone derivatives isolated from Garcinia (Clusiaceae) species. Phytochemistry Letters 14, 153-158.
Dzoyem, J.P., et al., 2015. Anti-inflammatory activity of benzophenone and xanthone derivatives isolated from Garcinia (Clusiaceae) species. Phytochemistry Letters, 14, p 153-158.
J.P. Dzoyem, et al., “Anti-inflammatory activity of benzophenone and xanthone derivatives isolated from Garcinia (Clusiaceae) species”, Phytochemistry Letters, vol. 14, 2015, pp. 153-158.
Dzoyem, J.P., Lannang, A.M., Fouotsa, H., Mbazoa, C.D., Nkengfack, A.E., Sewald, N., Eloff, J.N.: Anti-inflammatory activity of benzophenone and xanthone derivatives isolated from Garcinia (Clusiaceae) species. Phytochemistry Letters. 14, 153-158 (2015).
Dzoyem, Jean Paul, Lannang, Alain Meli, Fouotsa, Hugues, Mbazoa, Celine Djama, Nkengfack, Augustin Ephrem, Sewald, Norbert, and Eloff, Jacobus N. “Anti-inflammatory activity of benzophenone and xanthone derivatives isolated from Garcinia (Clusiaceae) species”. Phytochemistry Letters 14 (2015): 153-158.