Rhesus macaque MHC class I molecules show differential subcellular localizations

Rosner C, Kruse PH, Lübke T, Walter L (2010)
Immunogenetics 62(3): 149-158.

Journal Article | Published | English

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Abstract
The MHC class I gene family of rhesus macaques is characterised by considerable gene duplications. While a HLA-C-orthologous gene is absent, the Mamu-A and in particular the Mamu-B genes have expanded, giving rise to plastic haplotypes with differential gene content. Although some of the rhesus macaque MHC class I genes are known to be associated with susceptibility/resistance to infectious diseases, the functional significance of duplicated Mamu-A and Mamu-B genes and the expression pattern of their encoded proteins are largely unknown. Here, we present data of the subcellular localization of AcGFP-tagged Mamu-A and Mamu-B molecules. We found strong cell surface and low intracellular expression for Mamu-A1, Mamu-A2 and Mamu-A3-encoded molecules as well as for Mamu-B*01704, Mamu-B*02101, Mamu-B*04801, Mamu-B*06002 and Mamu-B*13401. In contrast, weak cell surface and strong intracellular expression was seen for Mamu-A4*1403, Mamu-B*01202, Mamu-B*02804, Mamu-B*03002, Mamu-B*05704, Mamu-I*010201 and Mamu-I*0121. The different expression patterns were assigned to the antigen-binding α1 and α2 domains, suggesting failure of peptide binding is responsible for retaining ‘intracellular’ Mamu class I molecules in the endoplasmic reticulum. These findings indicate a diverse functional role of the duplicated rhesus macaque MHC class I genes.
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Rosner C, Kruse PH, Lübke T, Walter L. Rhesus macaque MHC class I molecules show differential subcellular localizations. Immunogenetics. 2010;62(3):149-158.
Rosner, C., Kruse, P. H., Lübke, T., & Walter, L. (2010). Rhesus macaque MHC class I molecules show differential subcellular localizations. Immunogenetics, 62(3), 149-158.
Rosner, C., Kruse, P. H., Lübke, T., and Walter, L. (2010). Rhesus macaque MHC class I molecules show differential subcellular localizations. Immunogenetics 62, 149-158.
Rosner, C., et al., 2010. Rhesus macaque MHC class I molecules show differential subcellular localizations. Immunogenetics, 62(3), p 149-158.
C. Rosner, et al., “Rhesus macaque MHC class I molecules show differential subcellular localizations”, Immunogenetics, vol. 62, 2010, pp. 149-158.
Rosner, C., Kruse, P.H., Lübke, T., Walter, L.: Rhesus macaque MHC class I molecules show differential subcellular localizations. Immunogenetics. 62, 149-158 (2010).
Rosner, Cornelia, Kruse, Philip H., Lübke, Torben, and Walter, Lutz. “Rhesus macaque MHC class I molecules show differential subcellular localizations”. Immunogenetics 62.3 (2010): 149-158.
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PMID: 20151120
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