The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

Silventoinen K, Jelenkovic A, Sund R, Honda C, Aaltonen S, Yokoyama Y, Tarnoki AD, Tarnoki DL, Ning F, Ji F, Pang Z, et al. (2015)
Twin Research and Human Genetics 18(4): 348-360.

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Abstract
For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m(2)) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.
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Silventoinen K, Jelenkovic A, Sund R, et al. The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits. Twin Research and Human Genetics. 2015;18(4):348-360.
Silventoinen, K., Jelenkovic, A., Sund, R., Honda, C., Aaltonen, S., Yokoyama, Y., Tarnoki, A. D., et al. (2015). The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits. Twin Research and Human Genetics, 18(4), 348-360.
Silventoinen, K., Jelenkovic, A., Sund, R., Honda, C., Aaltonen, S., Yokoyama, Y., Tarnoki, A. D., Tarnoki, D. L., Ning, F., Ji, F., et al. (2015). The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits. Twin Research and Human Genetics 18, 348-360.
Silventoinen, K., et al., 2015. The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits. Twin Research and Human Genetics, 18(4), p 348-360.
K. Silventoinen, et al., “The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits”, Twin Research and Human Genetics, vol. 18, 2015, pp. 348-360.
Silventoinen, K., Jelenkovic, A., Sund, R., Honda, C., Aaltonen, S., Yokoyama, Y., Tarnoki, A.D., Tarnoki, D.L., Ning, F., Ji, F., Pang, Z., Ordonana, J.R., Sanchez-Romera, J.F., Colodro-Conde, L., Burt, S.A., Klump, K.L., Medland, S.E., Montgomery, G.W., Kandler, C., McAdams, T.A., Eley, T.C., Gregory, A.M., Saudino, K.J., Dubois, L., Boivin, M., Haworth, C.M.A., Plomin, R., Oncel, S.Y., Aliev, F., Stazi, M.A., Fagnani, C., D'Ippolito, C., Craig, J.M., Saffery, R., Siribaddana, S.H., Hotopf, M., Sumathipala, A., Spector, T., Mangino, M., Lachance, G., Gatz, M., Butler, D.A., Bayasgalan, G., Narandalai, D., Freitas, D.L., Maia, J.A., Harden, K.P., Tucker-Drob, E.M., Christensen, K., Skytthe, A., Kyvik, K.O., Hong, C., Chong, Y., Derom, C.A., Vlietinck, R.F., Loos, R.J.F., Cozen, W., Hwang, A.E., Mack, T.M., He, M., Ding, X., Chang, B., Silberg, J.L., Eaves, L.J., Maes, H.H., Cutler, T.L., Hopper, J.L., Aujard, K., Magnusson, P.K.E., Pedersen, N.L., Aslan, A.K.D., Song, Y.-M., Yang, S., Lee, K., Baker, L.A., Tuvblad, C., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Heikkila, K., Tan, Q., Zhang, D., Swan, G.E., Krasnow, R., Jang, K.L., Knafo-Noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R.F., Mcgue, M., Pahlen, S., Tynelius, P., Duncan, G.E., Buchwald, D., Corley, R.P., Huibregtse, B.M., Nelson, T.L., Whitfield, K.E., Franz, C.E., Kremen, W.S., Lyons, M.J., Ooki, S., Brandt, I., Nilsen, T.S., Inui, F., Watanabe, M., Bartels, M., van Beijsterveldt, T.C.E.M., Wardle, J., Llewellyn, C.H., Fisher, A., Rebato, E., Martin, N.G., Iwatani, Y., Hayakawa, K., Rasmussen, F., Sung, J., Harris, J.R., Willemsen, G., Busjahn, A., Goldberg, J.H., Boomsma, D.I., Hur, Y.-M., Sorensen, T.I.A., Kaprio, J.: The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits. Twin Research and Human Genetics. 18, 348-360 (2015).
Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Honda, Chika, Aaltonen, Sari, Yokoyama, Yoshie, Tarnoki, Adam D., Tarnoki, David L., Ning, Feng, Ji, Fuling, Pang, Zengchang, Ordonana, Juan R., Sanchez-Romera, Juan F., Colodro-Conde, Lucia, Burt, S. Alexandra, Klump, Kelly L., Medland, Sarah E., Montgomery, Grant W., Kandler, Christian, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., Saudino, Kimberly J., Dubois, Lise, Boivin, Michel, Haworth, Claire M. A., Plomin, Robert, Oncel, Sevgi Y., Aliev, Fazil, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Craig, Jeffrey M., Saffery, Richard, Siribaddana, Sisira H., Hotopf, Matthew, Sumathipala, Athula, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Gatz, Margaret, Butler, David A., Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Freitas, Duarte L., Maia, Jose Antonio, Harden, K. Paige, Tucker-Drob, Elliot M., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O., Hong, Changhee, Chong, Youngsook, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., He, Mingguang, Ding, Xiaohu, Chang, Billy, Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Cutler, Tessa L., Hopper, John L., Aujard, Kelly, Magnusson, Patrik K. E., Pedersen, Nancy L., Aslan, Anna K. Dahl, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Baker, Laura A., Tuvblad, Catherine, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Heikkila, Kauko, Tan, Qihua, Zhang, Dongfeng, Swan, Gary E., Krasnow, Ruth, Jang, Kerry L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Lichtenstein, Paul, Krueger, Robert F., Mcgue, Matt, Pahlen, Shandell, Tynelius, Per, Duncan, Glen E., Buchwald, Dedra, Corley, Robin P., Huibregtse, Brooke M., Nelson, Tracy L., Whitfield, Keith E., Franz, Carol E., Kremen, William S., Lyons, Michael J., Ooki, Syuichi, Brandt, Ingunn, Nilsen, Thomas Sevenius, Inui, Fujio, Watanabe, Mikio, Bartels, Meike, van Beijsterveldt, Toos C. E. M., Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, Rebato, Esther, Martin, Nicholas G., Iwatani, Yoshinori, Hayakawa, Kazuo, Rasmussen, Finn, Sung, Joohon, Harris, Jennifer R., Willemsen, Gonneke, Busjahn, Andreas, Goldberg, Jack H., Boomsma, Dorret I., Hur, Yoon-Mi, Sorensen, Thorkild I. A., and Kaprio, Jaakko. “The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits”. Twin Research and Human Genetics 18.4 (2015): 348-360.
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1 Citation in Europe PMC

Data provided by Europe PubMed Central.

Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts.
Jelenkovic A, Sund R, Hur YM, Yokoyama Y, Hjelmborg JV, Moller S, Honda C, Magnusson PK, Pedersen NL, Ooki S, Aaltonen S, Stazi MA, Fagnani C, D'Ippolito C, Freitas DL, Maia JA, Ji F, Ning F, Pang Z, Rebato E, Busjahn A, Kandler C, Saudino KJ, Jang KL, Cozen W, Hwang AE, Mack TM, Gao W, Yu C, Li L, Corley RP, Huibregtse BM, Derom CA, Vlietinck RF, Loos RJ, Heikkila K, Wardle J, Llewellyn CH, Fisher A, McAdams TA, Eley TC, Gregory AM, He M, Ding X, Bjerregaard-Andersen M, Beck-Nielsen H, Sodemann M, Tarnoki AD, Tarnoki DL, Knafo-Noam A, Mankuta D, Abramson L, Burt SA, Klump KL, Silberg JL, Eaves LJ, Maes HH, Krueger RF, McGue M, Pahlen S, Gatz M, Butler DA, Bartels M, van Beijsterveldt TC, Craig JM, Saffery R, Dubois L, Boivin M, Brendgen M, Dionne G, Vitaro F, Martin NG, Medland SE, Montgomery GW, Swan GE, Krasnow R, Tynelius P, Lichtenstein P, Haworth CM, Plomin R, Bayasgalan G, Narandalai D, Harden KP, Tucker-Drob EM, Spector T, Mangino M, Lachance G, Baker LA, Tuvblad C, Duncan GE, Buchwald D, Willemsen G, Skytthe A, Kyvik KO, Christensen K, Oncel SY, Aliev F, Rasmussen F, Goldberg JH, Sorensen TI, Boomsma DI, Kaprio J, Silventoinen K., Sci Rep 6(), 2016
PMID: 27333805

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