Two 2,6-Dioxabicyclo[3.3.1]nonan-3-ones from Phragmanthera capitata (Spreng.) Balle (Loranthaceae)

Lenta Ndjakou B, Ateba JT, Chouna JR, Aminake MN, Nardella F, Pradel G, Neumann B, Stammler H-G, Vonthron-Senecheau C, Ngouela S, Sewald N (2015)
Helvetica Chimica Acta 98(7): 945-952.

Journal Article | Published | English

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Abstract
Phytochemical investigation of the leaves of Phragmanthera capitata collected on Cassia spectabilis tree led to the isolation of two natural lactones, rel-(1R,5S,7S)-7-[2-(4-hydroxyphenyl)ethyl]-2,6-dioxabicyclo[3.3.1]nonan-3-one (1) and 4-{2-[rel-(1R,3R,5S)-7-oxo-2,6-dioxabicyclo[3.3.1]non-3-yl]ethyl}phenyl 3,4,5-trihydroxybenzoate (2) together with the known compounds betulinic acid (3), dodoneine (4), quercetin 3-O--L-rhamnopyranoside (5), quercetin 3-O--L-arabinofuranoside (6), quercetin (7), betulin (8), lupeol (9), and sitosterol (10). Their structures were established by means of modern spectroscopic techniques, and the relative configuration of compound 1 was confirmed by X-ray analysis. Compounds 1 and 2 were tested in vitro for their antiplasmodial activity against the Plasmodium falciparum chloroquine sensitive-strains NF54 and 3D7. Compound 2 exhibited good antiplasmodial activity against both strains with IC50 of 2.4 and 4.9M, respectively, while compound 1 was inactive.
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Lenta Ndjakou B, Ateba JT, Chouna JR, et al. Two 2,6-Dioxabicyclo[3.3.1]nonan-3-ones from Phragmanthera capitata (Spreng.) Balle (Loranthaceae). Helvetica Chimica Acta. 2015;98(7):945-952.
Lenta Ndjakou, B., Ateba, J. T., Chouna, J. R., Aminake, M. N., Nardella, F., Pradel, G., Neumann, B., et al. (2015). Two 2,6-Dioxabicyclo[3.3.1]nonan-3-ones from Phragmanthera capitata (Spreng.) Balle (Loranthaceae). Helvetica Chimica Acta, 98(7), 945-952.
Lenta Ndjakou, B., Ateba, J. T., Chouna, J. R., Aminake, M. N., Nardella, F., Pradel, G., Neumann, B., Stammler, H. - G., Vonthron-Senecheau, C., Ngouela, S., et al. (2015). Two 2,6-Dioxabicyclo[3.3.1]nonan-3-ones from Phragmanthera capitata (Spreng.) Balle (Loranthaceae). Helvetica Chimica Acta 98, 945-952.
Lenta Ndjakou, B., et al., 2015. Two 2,6-Dioxabicyclo[3.3.1]nonan-3-ones from Phragmanthera capitata (Spreng.) Balle (Loranthaceae). Helvetica Chimica Acta, 98(7), p 945-952.
B. Lenta Ndjakou, et al., “Two 2,6-Dioxabicyclo[3.3.1]nonan-3-ones from Phragmanthera capitata (Spreng.) Balle (Loranthaceae)”, Helvetica Chimica Acta, vol. 98, 2015, pp. 945-952.
Lenta Ndjakou, B., Ateba, J.T., Chouna, J.R., Aminake, M.N., Nardella, F., Pradel, G., Neumann, B., Stammler, H.-G., Vonthron-Senecheau, C., Ngouela, S., Sewald, N.: Two 2,6-Dioxabicyclo[3.3.1]nonan-3-ones from Phragmanthera capitata (Spreng.) Balle (Loranthaceae). Helvetica Chimica Acta. 98, 945-952 (2015).
Lenta Ndjakou, Bruno, Ateba, Joel T., Chouna, Jean R., Aminake, Makoah N., Nardella, Flore, Pradel, Gabriele, Neumann, Beate, Stammler, Hans-Georg, Vonthron-Senecheau, Catherine, Ngouela, Silvere, and Sewald, Norbert. “Two 2,6-Dioxabicyclo[3.3.1]nonan-3-ones from Phragmanthera capitata (Spreng.) Balle (Loranthaceae)”. Helvetica Chimica Acta 98.7 (2015): 945-952.
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