Within-population Y-linked genetic variation for lifespan in Drosophila melanogaster

Griffin RM, Le Gall D, Schielzeth H, Friberg U (2015)
Journal of Evolutionary Biology 28(11): 1940-1947.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The view that the Y chromosome is of little importance for phenotypic evolution stems from early studies of Drosophila melanogaster. This species’ Y chromosome contains only 13 protein coding genes, is almost entirely heterochromatic, and is not necessary for male viability. Population genetic theory further suggests that non-neutral variation can only be maintained at the Y chromosome under special circumstances. Yet, recent studies suggest that the D. melanogaster Y chromosome trans-regulates hundreds to thousands of X and autosomal genes. This finding suggests that the Y chromosome may play a far more active role in adaptive evolution than has previously been assumed. To evaluate the potential for the Y chromosome to contribute to phenotypic evolution from standing genetic variation, we test for Y-linked variation in lifespan within a population of D. melanogaster. Assessing variation for lifespan provides a powerful test because lifespan i) shows sexual dimorphism, which the Y is primarily predicted to contribute to, ii) is influenced by many genes, which provides the Y with many potential regulatory targets, and iii) is sensitive to heterochromatin remodelling, a mechanism through which the Y chromosome is believed to regulate gene expression. Our results show a small but significant effect of the Y chromosome, and thus suggest that the Y chromosome has the potential to respond to selection from standing genetic variation. Despite its small effect size, Y-linked variation may still be important, in particular when evolution of sexual dimorphism is genetically constrained elsewhere in the genome.
Erscheinungsjahr
Zeitschriftentitel
Journal of Evolutionary Biology
Band
28
Zeitschriftennummer
11
Seite
1940-1947
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Griffin RM, Le Gall D, Schielzeth H, Friberg U. Within-population Y-linked genetic variation for lifespan in Drosophila melanogaster. Journal of Evolutionary Biology. 2015;28(11):1940-1947.
Griffin, R. M., Le Gall, D., Schielzeth, H., & Friberg, U. (2015). Within-population Y-linked genetic variation for lifespan in Drosophila melanogaster. Journal of Evolutionary Biology, 28(11), 1940-1947. doi:10.1111/jeb.12708
Griffin, R. M., Le Gall, D., Schielzeth, H., and Friberg, U. (2015). Within-population Y-linked genetic variation for lifespan in Drosophila melanogaster. Journal of Evolutionary Biology 28, 1940-1947.
Griffin, R.M., et al., 2015. Within-population Y-linked genetic variation for lifespan in Drosophila melanogaster. Journal of Evolutionary Biology, 28(11), p 1940-1947.
R.M. Griffin, et al., “Within-population Y-linked genetic variation for lifespan in Drosophila melanogaster”, Journal of Evolutionary Biology, vol. 28, 2015, pp. 1940-1947.
Griffin, R.M., Le Gall, D., Schielzeth, H., Friberg, U.: Within-population Y-linked genetic variation for lifespan in Drosophila melanogaster. Journal of Evolutionary Biology. 28, 1940-1947 (2015).
Griffin, Robert M, Le Gall, Damien, Schielzeth, Holger, and Friberg, Urban. “Within-population Y-linked genetic variation for lifespan in Drosophila melanogaster”. Journal of Evolutionary Biology 28.11 (2015): 1940-1947.

3 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Reproductive activity triggers accelerated male mortality and decreases lifespan: genetic and gene expression determinants in Drosophila.
Branco AT, Schilling L, Silkaitis K, Dowling DK, Lemos B., Heredity (Edinb) 118(3), 2017
PMID: 27731328
The Drosophila simulans Y chromosome interacts with the autosomes to influence male fitness.
Archer CR, Stephens RM, Sharma MD, Hosken DJ., J Evol Biol 30(10), 2017
PMID: 28703322

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