Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii

Fouotsa H, Lannang AM, Dzoyem JP, Tatsimo SJN, Neumann B, Mbazoa CD, Razakarivony AA, Nkengfack AE, Eloff JN, Sewald N (2015)
Planta Medica 81(7): 594-599.

Journal Article | Published | English

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Abstract
A new prenylated xanthone, 1,3,5,8-tetrahydroxy-2-(3-methybut-2-enyl)-4-(3,7-dimethylocta-2,6-dienyl) xanthone (1), and a new benzophenone (2), together with four known xanthone derivatives, cheffouxanthone (3), smeathxanthone A (4), smeathxanthone B (5), ananixanthone (6), and two pentacyclic triterpenes, epi-friedelinol (7) and friedelin (8), were isolated from the stem bark of Garcinia smeathmannii. The structures of the compounds were elucidated on the basis of 1D and 2DNMR experiments, and compound 2 was further characterized and confirmed by single X-ray analysis. Compounds 1, 2, and 3 exhibited the most prominent antibacterial activity against gram-positive Enterococcus faecalis with minimal inhibitory concentration values of 8, 8, and 2 mu g/mL, respectively, while compounds 1, 3, 4, and 6 showed the capacity to scavenge free radicals.
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Fouotsa H, Lannang AM, Dzoyem JP, et al. Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica. 2015;81(7):594-599.
Fouotsa, H., Lannang, A. M., Dzoyem, J. P., Tatsimo, S. J. N., Neumann, B., Mbazoa, C. D., Razakarivony, A. A., et al. (2015). Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica, 81(7), 594-599.
Fouotsa, H., Lannang, A. M., Dzoyem, J. P., Tatsimo, S. J. N., Neumann, B., Mbazoa, C. D., Razakarivony, A. A., Nkengfack, A. E., Eloff, J. N., and Sewald, N. (2015). Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica 81, 594-599.
Fouotsa, H., et al., 2015. Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica, 81(7), p 594-599.
H. Fouotsa, et al., “Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii”, Planta Medica, vol. 81, 2015, pp. 594-599.
Fouotsa, H., Lannang, A.M., Dzoyem, J.P., Tatsimo, S.J.N., Neumann, B., Mbazoa, C.D., Razakarivony, A.A., Nkengfack, A.E., Eloff, J.N., Sewald, N.: Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica. 81, 594-599 (2015).
Fouotsa, Hugues, Lannang, Alain Meli, Dzoyem, Jean Paul, Tatsimo, Simplice J. N., Neumann, Beate, Mbazoa, Celine Djama, Razakarivony, Andrianambinina A., Nkengfack, Augustin Ephrem, Eloff, Jacobus N., and Sewald, Norbert. “Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii”. Planta Medica 81.7 (2015): 594-599.
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PMID: 25798641
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