Redox-dependent translocation of the heat shock transcription factor AtHSFA8 from the cytosol to the nucleus in Arabidopsis thaliana

Giesguth M, Sahm A, Simon S, Dietz K-J (2015)
FEBS letters 589(6): 718-725.

Journal Article | Published | English

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Abstract
The hypothesis is tested that some heat stress transcription factors (HSFs) are activated after formation of inter- or intramolecular disulfide bonds. Based on in silico analyses we identified conserved cysteinyl residues in AtHSFA8 that might function as redox sensors in plants. AtHSFA8 represents a redox-sensitive transcription factor since upon treatment of protoplasts with H2O2 YFP-labeled HSFA8 was translocated to the nucleus in a time-dependent manner. Site-directed mutagenesis of the conserved residues Cys24 and Cys269 blocked translocation of HSFA8 to the nucleus. The findings concur with a model where HSFA8 functions as redox sensing transcription factor within the stress-responsive transcriptional network.
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Giesguth M, Sahm A, Simon S, Dietz K-J. Redox-dependent translocation of the heat shock transcription factor AtHSFA8 from the cytosol to the nucleus in Arabidopsis thaliana. FEBS letters. 2015;589(6):718-725.
Giesguth, M., Sahm, A., Simon, S., & Dietz, K. - J. (2015). Redox-dependent translocation of the heat shock transcription factor AtHSFA8 from the cytosol to the nucleus in Arabidopsis thaliana. FEBS letters, 589(6), 718-725.
Giesguth, M., Sahm, A., Simon, S., and Dietz, K. - J. (2015). Redox-dependent translocation of the heat shock transcription factor AtHSFA8 from the cytosol to the nucleus in Arabidopsis thaliana. FEBS letters 589, 718-725.
Giesguth, M., et al., 2015. Redox-dependent translocation of the heat shock transcription factor AtHSFA8 from the cytosol to the nucleus in Arabidopsis thaliana. FEBS letters, 589(6), p 718-725.
M. Giesguth, et al., “Redox-dependent translocation of the heat shock transcription factor AtHSFA8 from the cytosol to the nucleus in Arabidopsis thaliana”, FEBS letters, vol. 589, 2015, pp. 718-725.
Giesguth, M., Sahm, A., Simon, S., Dietz, K.-J.: Redox-dependent translocation of the heat shock transcription factor AtHSFA8 from the cytosol to the nucleus in Arabidopsis thaliana. FEBS letters. 589, 718-725 (2015).
Giesguth, Miriam, Sahm, Arne, Simon, Swen, and Dietz, Karl-Josef. “Redox-dependent translocation of the heat shock transcription factor AtHSFA8 from the cytosol to the nucleus in Arabidopsis thaliana”. FEBS letters 589.6 (2015): 718-725.
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Identification, isolation, and expression analysis of heat shock transcription factors in the diploid woodland strawberry Fragaria vesca.
Hu Y, Han YT, Wei W, Li YJ, Zhang K, Gao YR, Zhao FL, Feng JY., Front Plant Sci 6(), 2015
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