GraphSAW: A web-based system for graphical analysis of drug interactions and side effects using pharmaceutical and molecular data

Shoshi A, Hoppe T, Kormeier B, Ogultarhan V, Hofestädt R (2015)
BMC Medical Informatics and Decision Making 15: 15.

Download
OA
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Volltext vorhanden für diesen Nachweis
Abstract / Bemerkung
Background Adverse drug reactions are one of the most common causes of death in industrialized Western countries. Nowadays, empirical data from clinical studies for the approval and monitoring of drugs and molecular databases is available. Methods The integration of database information is a promising method for providing well-based knowledge to avoid adverse drug reactions. This paper presents our web-based decision support system GraphSAW which analyzes and evaluates drug interactions and side effects based on data from two commercial and two freely available molecular databases. The system is able to analyze single and combined drug-drug interactions, drug-molecule interactions as well as single and cumulative side effects. In addition, it allows exploring associative networks of drugs, molecules, metabolic pathways, and diseases in an intuitive way. The molecular medication analysis includes the capabilities of the upper features. Results A statistical evaluation of the integrated data and top 20 drugs concerning drug interactions and side effects is performed. The results of the data analysis give an overview of all theoretically possible drug interactions and side effects. The evaluation shows a mismatch between pharmaceutical and molecular databases. The concordance of drug interactions was about 12% and 9% of drug side effects. An application case with prescribed data of 11 patients is presented in order to demonstrate the functionality of the system under real conditions. For each patient at least two interactions occured in every medication and about 8% of total diseases were possibly induced by drug therapy. Conclusions GraphSAW (http://tunicata.techfak.uni-bielefeld.de/graphsaw/ webcite) is meant to be a web-based system for health professionals and researchers. GraphSAW provides comprehensive drug-related knowledge and an improved medication analysis which may support efforts to reduce the risk of medication errors and numerous drastic side effects.
Erscheinungsjahr
Zeitschriftentitel
BMC Medical Informatics and Decision Making
Band
15
Artikelnummer
15
ISSN
Finanzierungs-Informationen
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft and the Open Access Publication Fund of Bielefeld University.
PUB-ID

Zitieren

Shoshi A, Hoppe T, Kormeier B, Ogultarhan V, Hofestädt R. GraphSAW: A web-based system for graphical analysis of drug interactions and side effects using pharmaceutical and molecular data. BMC Medical Informatics and Decision Making. 2015;15: 15.
Shoshi, A., Hoppe, T., Kormeier, B., Ogultarhan, V., & Hofestädt, R. (2015). GraphSAW: A web-based system for graphical analysis of drug interactions and side effects using pharmaceutical and molecular data. BMC Medical Informatics and Decision Making, 15, 15. doi:10.1186/s12911-015-0139-5
Shoshi, A., Hoppe, T., Kormeier, B., Ogultarhan, V., and Hofestädt, R. (2015). GraphSAW: A web-based system for graphical analysis of drug interactions and side effects using pharmaceutical and molecular data. BMC Medical Informatics and Decision Making 15:15.
Shoshi, A., et al., 2015. GraphSAW: A web-based system for graphical analysis of drug interactions and side effects using pharmaceutical and molecular data. BMC Medical Informatics and Decision Making, 15: 15.
A. Shoshi, et al., “GraphSAW: A web-based system for graphical analysis of drug interactions and side effects using pharmaceutical and molecular data”, BMC Medical Informatics and Decision Making, vol. 15, 2015, : 15.
Shoshi, A., Hoppe, T., Kormeier, B., Ogultarhan, V., Hofestädt, R.: GraphSAW: A web-based system for graphical analysis of drug interactions and side effects using pharmaceutical and molecular data. BMC Medical Informatics and Decision Making. 15, : 15 (2015).
Shoshi, Alban, Hoppe, Tobias, Kormeier, Benjamin, Ogultarhan, Venus, and Hofestädt, Ralf. “GraphSAW: A web-based system for graphical analysis of drug interactions and side effects using pharmaceutical and molecular data”. BMC Medical Informatics and Decision Making 15 (2015): 15.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Copyright Statement:
This Item is protected by copyright and/or related rights. [...]
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2016-07-06T12:59:21Z

1 Zitation in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Computerized Clinical Decision Support: Contributions from 2015.
Koutkias V, Bouaud J., Yearb Med Inform (1), 2016
PMID: 27830247

28 References

Daten bereitgestellt von Europe PubMed Central.


AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 2009

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 25881043
PubMed | Europe PMC

Suchen in

Google Scholar