Estimating dichotomised outcomes in two groups with unequal variances: a distributional approach

Sauzet O, Peacock JL (2014)
Statistics in Medicine 33(26): 4547-4559.

Journal Article | Published | English

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Abstract
Dichotomisation in medical research is sometimes necessary for decision-making or communication purposes. This practice has been criticised in the case of continuous data, and it has been said that means should be compared instead. However when the two groups have unequal variances, comparing means might not show the whole picture as a particular group with a risk defined by a threshold in an outcome may have been affected differently by an intervention than when there is a simple shift of distribution. A statistically sound method using a distributional approach for the dichotomisation of normally distributed outcomes has been described under the assumption of equal variances. This assumption is not sustainable in some situations, and in this work, we develop the method further to cover the case of unequal variances. Through examples from the literature and our own data, we illustrate the effect of unequal variance on dichotomised estimates and present a validation of the method through simulations. Copyright (C) 2014 John Wiley & Sons, Ltd.
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Sauzet O, Peacock JL. Estimating dichotomised outcomes in two groups with unequal variances: a distributional approach. Statistics in Medicine. 2014;33(26):4547-4559.
Sauzet, O., & Peacock, J. L. (2014). Estimating dichotomised outcomes in two groups with unequal variances: a distributional approach. Statistics in Medicine, 33(26), 4547-4559.
Sauzet, O., and Peacock, J. L. (2014). Estimating dichotomised outcomes in two groups with unequal variances: a distributional approach. Statistics in Medicine 33, 4547-4559.
Sauzet, O., & Peacock, J.L., 2014. Estimating dichotomised outcomes in two groups with unequal variances: a distributional approach. Statistics in Medicine, 33(26), p 4547-4559.
O. Sauzet and J.L. Peacock, “Estimating dichotomised outcomes in two groups with unequal variances: a distributional approach”, Statistics in Medicine, vol. 33, 2014, pp. 4547-4559.
Sauzet, O., Peacock, J.L.: Estimating dichotomised outcomes in two groups with unequal variances: a distributional approach. Statistics in Medicine. 33, 4547-4559 (2014).
Sauzet, Odile, and Peacock, J. L. “Estimating dichotomised outcomes in two groups with unequal variances: a distributional approach”. Statistics in Medicine 33.26 (2014): 4547-4559.
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2 Citations in Europe PMC

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Dichotomisation using a distributional approach when the outcome is skewed.
Sauzet O, Ofuya M, Peacock JL., BMC Med Res Methodol 15(), 2015
PMID: 25902850

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