A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp CNQ-509

Zeyhle P, Bauer JS, Steimle M, Leipoldt F, Roesch M, Kalinowski J, Gross H, Heide L (2014)
ChemBioChem 15(16): 2385-2392.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Streptomyces sp. CNQ-509 produces the rare O-prenylated phenazines marinophenazines A and B. To identify the enzyme catalyzing the O-prenyl transfer in marinophenazine biosynthesis, we sequenced the genome of S. sp. CNQ-509. This led to the identification of two genomic loci harboring putative phenazine biosynthesis genes. The first locus contains orthologues for all seven genes involved in phenazine-1-carboxylic acid biosynthesis in pseudomonads. The second locus contains two known phenazine biosynthesis genes and a putative prenyltransferase gene termed cnqPT1. cnqPT1 codes for a membrane protein with sequence similarity to the prenyltransferase UbiA of ubiquinone biosynthesis. The enzyme CnqPT1 was identified as a 1,6-dihydroxyphenazine geranyltransferase, which catalyzes the CO bond formation between C-1 of the geranyl moiety and O-6 of the phenazine scaffold. CnqPT1 is the first example of a prenyltransferase catalyzing O-prenyl transfer to a phenazine.
Erscheinungsjahr
Zeitschriftentitel
ChemBioChem
Band
15
Zeitschriftennummer
16
Seite
2385-2392
ISSN
PUB-ID

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Zeyhle P, Bauer JS, Steimle M, et al. A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp CNQ-509. ChemBioChem. 2014;15(16):2385-2392.
Zeyhle, P., Bauer, J. S., Steimle, M., Leipoldt, F., Roesch, M., Kalinowski, J., Gross, H., et al. (2014). A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp CNQ-509. ChemBioChem, 15(16), 2385-2392. doi:10.1002/cbic.201402394
Zeyhle, P., Bauer, J. S., Steimle, M., Leipoldt, F., Roesch, M., Kalinowski, J., Gross, H., and Heide, L. (2014). A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp CNQ-509. ChemBioChem 15, 2385-2392.
Zeyhle, P., et al., 2014. A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp CNQ-509. ChemBioChem, 15(16), p 2385-2392.
P. Zeyhle, et al., “A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp CNQ-509”, ChemBioChem, vol. 15, 2014, pp. 2385-2392.
Zeyhle, P., Bauer, J.S., Steimle, M., Leipoldt, F., Roesch, M., Kalinowski, J., Gross, H., Heide, L.: A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp CNQ-509. ChemBioChem. 15, 2385-2392 (2014).
Zeyhle, Philipp, Bauer, Judith S., Steimle, Marco, Leipoldt, Franziska, Roesch, Manuela, Kalinowski, Jörn, Gross, Harald, and Heide, Lutz. “A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp CNQ-509”. ChemBioChem 15.16 (2014): 2385-2392.

6 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi.
Yang YL, Zhang S, Ma K, Xu Y, Tao Q, Chen Y, Chen J, Guo S, Ren J, Wang W, Tao Y, Yin WB, Liu H., Angew Chem Int Ed Engl 56(17), 2017
PMID: 28371074
Marine natural products.
Blunt JW, Copp BR, Keyzers RA, Munro MH, Prinsep MR., Nat Prod Rep 33(3), 2016
PMID: 26837534
Prenyltransferases as key enzymes in primary and secondary metabolism.
Winkelblech J, Fan A, Li SM., Appl Microbiol Biotechnol 99(18), 2015
PMID: 26216239

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