Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach

Hoefener M, Pachl F, Take T, Fischer von Mollard G, Kuster B, Sewald N (2014)
Journal of Proteome Research 13(8): 3628-3634.

Journal Article | Published | English

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Abstract
Many neurodegenerative diseases, such as Parkinson's disease, can be directly correlated with the deregulation in neuronal signaling. Hence, it is indispensable for therapy development to understand the participating signaling processes. Because the activity of the involved protein kinases is of major interest for the investigation of these signaling processes, an affinity-based chemical proteomics approach that allows for the activity profiling of protein kinases was developed within this study. This approach was applied to investigate the RET9 receptor tyrosine kinase signaling pathway that plays a central role in neuronal signaling. In addition to already known RET9 downstream targets, several other protein kinases were found to be highly activated upon RET9 stimulation.
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Hoefener M, Pachl F, Take T, Fischer von Mollard G, Kuster B, Sewald N. Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach. Journal of Proteome Research. 2014;13(8):3628-3634.
Hoefener, M., Pachl, F., Take, T., Fischer von Mollard, G., Kuster, B., & Sewald, N. (2014). Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach. Journal of Proteome Research, 13(8), 3628-3634.
Hoefener, M., Pachl, F., Take, T., Fischer von Mollard, G., Kuster, B., and Sewald, N. (2014). Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach. Journal of Proteome Research 13, 3628-3634.
Hoefener, M., et al., 2014. Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach. Journal of Proteome Research, 13(8), p 3628-3634.
M. Hoefener, et al., “Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach”, Journal of Proteome Research, vol. 13, 2014, pp. 3628-3634.
Hoefener, M., Pachl, F., Take, T., Fischer von Mollard, G., Kuster, B., Sewald, N.: Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach. Journal of Proteome Research. 13, 3628-3634 (2014).
Hoefener, Michael, Pachl, Fiona, Take, Tim, Fischer von Mollard, Gabriele, Kuster, Bernhard, and Sewald, Norbert. “Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach”. Journal of Proteome Research 13.8 (2014): 3628-3634.
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Inhibitor-based affinity probes for the investigation of JAK signaling pathways.
Hofener M, Pachl F, Kuster B, Sewald N., Proteomics 15(17), 2015
PMID: 25959371

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PMID: 24942550
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