Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments

Heidlindemann M, Rulli G, Berkessel A, Hummel W, Gröger H (2014)
ACS Catalysis 4(4): 1099-1103.

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Abstract
A proof of concept for the combination of an asymmetric organocatalytic reaction with a biotransformation toward a "one-pot like" process for 1,3-diols based on immobilized organo- and biocatalysts, which are utilized in different compartments, is demonstrated. This process which runs completely in organic media consists of an initial proline-derivative-catalyzed aldol reaction and a subsequent reduction of the aldol adduct catalyzed by an alcohol dehydrogenase (ADH) without the need for intermediate isolation. Economically attractive superabsorber-based coimmobilization for the ADH and its cofactor NAD(+) turned out to give a highly efficient biocatalyst with excellent reusability and simple product separation from the immobilizate under avoidance of any tedious extraction steps during the overall process.
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Heidlindemann M, Rulli G, Berkessel A, Hummel W, Gröger H. Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments. ACS Catalysis. 2014;4(4):1099-1103.
Heidlindemann, M., Rulli, G., Berkessel, A., Hummel, W., & Gröger, H. (2014). Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments. ACS Catalysis, 4(4), 1099-1103.
Heidlindemann, M., Rulli, G., Berkessel, A., Hummel, W., and Gröger, H. (2014). Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments. ACS Catalysis 4, 1099-1103.
Heidlindemann, M., et al., 2014. Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments. ACS Catalysis, 4(4), p 1099-1103.
M. Heidlindemann, et al., “Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments”, ACS Catalysis, vol. 4, 2014, pp. 1099-1103.
Heidlindemann, M., Rulli, G., Berkessel, A., Hummel, W., Gröger, H.: Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments. ACS Catalysis. 4, 1099-1103 (2014).
Heidlindemann, Marcel, Rulli, Giuseppe, Berkessel, Albrecht, Hummel, Werner, and Gröger, Harald. “Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments”. ACS Catalysis 4.4 (2014): 1099-1103.
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