Cytotoxic Compounds from the Leaves of Garcinia polyantha

Lannang AM, Tatsimo SJN, Fouotsa H, Dzoyem JP, Saxena AK, Sewald N (2014)
Chemistry & Biodiversity 11(6): 975-981.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
A new compound, named banganxanthone C (=12-(1,1-dimethylprop-2-en-1-yl)-5,10-dihydroxy-9-methoxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H, 6H-pyrano[3,2-b]xanthen-6-one; 4), together with five known compounds, were isolated from the leaves of Garcinia polyantha. The structures of the compounds were elucidated on the basis of 1D- and 2D-NMR spectroscopy. Among the known compounds, two were xanthones, one was a pentacyclic triterpene, one sterol, and one benzophenone derivative. Isoxanthochymol (2) and 4-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one (3) exhibited significant antiproliferative activity against the leukemia cell line TPH-1 with IC50 inhibition values of 1.5 and 2.8 mu g/ml, respectively. The cytotoxic activity was found to be related to apoptosis induction.
Erscheinungsjahr
Zeitschriftentitel
Chemistry & Biodiversity
Band
11
Zeitschriftennummer
6
Seite
975-981
ISSN
PUB-ID

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Lannang AM, Tatsimo SJN, Fouotsa H, Dzoyem JP, Saxena AK, Sewald N. Cytotoxic Compounds from the Leaves of Garcinia polyantha. Chemistry & Biodiversity. 2014;11(6):975-981.
Lannang, A. M., Tatsimo, S. J. N., Fouotsa, H., Dzoyem, J. P., Saxena, A. K., & Sewald, N. (2014). Cytotoxic Compounds from the Leaves of Garcinia polyantha. Chemistry & Biodiversity, 11(6), 975-981. doi:10.1002/cbdv.201300401
Lannang, A. M., Tatsimo, S. J. N., Fouotsa, H., Dzoyem, J. P., Saxena, A. K., and Sewald, N. (2014). Cytotoxic Compounds from the Leaves of Garcinia polyantha. Chemistry & Biodiversity 11, 975-981.
Lannang, A.M., et al., 2014. Cytotoxic Compounds from the Leaves of Garcinia polyantha. Chemistry & Biodiversity, 11(6), p 975-981.
A.M. Lannang, et al., “Cytotoxic Compounds from the Leaves of Garcinia polyantha”, Chemistry & Biodiversity, vol. 11, 2014, pp. 975-981.
Lannang, A.M., Tatsimo, S.J.N., Fouotsa, H., Dzoyem, J.P., Saxena, A.K., Sewald, N.: Cytotoxic Compounds from the Leaves of Garcinia polyantha. Chemistry & Biodiversity. 11, 975-981 (2014).
Lannang, Alain Meli, Tatsimo, Simplice J. N., Fouotsa, Hugues, Dzoyem, Jean Paul, Saxena, Ajit Kumar, and Sewald, Norbert. “Cytotoxic Compounds from the Leaves of Garcinia polyantha”. Chemistry & Biodiversity 11.6 (2014): 975-981.

2 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

A new depsidone derivative from the leaves of Garcinia polyantha.
Lannang AM, Sema DK, Tatsimo SJN, Tankeu VFT, Tegha HF, Wansi JD, Shiono Y, Sewald N., Nat Prod Res 32(9), 2018
PMID: 28931317
Two new biphenyls from the stems of Garcinia tetralata.
Ji BK, Gao XM, Cui D, Wang SS, Huang WZ, Li YK, Mei SX, Yang Z, Li GP, Jiang MY, He YH, Jiang ZY, Du G, Pan XX, Liu WX, Hu QF., Nat Prod Res 31(13), 2017
PMID: 28161987

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