Cytotoxic Compounds from the Leaves of Garcinia polyantha

Lannang AM, Tatsimo SJN, Fouotsa H, Dzoyem JP, Saxena AK, Sewald N (2014)
Chemistry & Biodiversity 11(6): 975-981.

Journal Article | Published | English

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Abstract
A new compound, named banganxanthone C (=12-(1,1-dimethylprop-2-en-1-yl)-5,10-dihydroxy-9-methoxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H, 6H-pyrano[3,2-b]xanthen-6-one; 4), together with five known compounds, were isolated from the leaves of Garcinia polyantha. The structures of the compounds were elucidated on the basis of 1D- and 2D-NMR spectroscopy. Among the known compounds, two were xanthones, one was a pentacyclic triterpene, one sterol, and one benzophenone derivative. Isoxanthochymol (2) and 4-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one (3) exhibited significant antiproliferative activity against the leukemia cell line TPH-1 with IC50 inhibition values of 1.5 and 2.8 mu g/ml, respectively. The cytotoxic activity was found to be related to apoptosis induction.
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Lannang AM, Tatsimo SJN, Fouotsa H, Dzoyem JP, Saxena AK, Sewald N. Cytotoxic Compounds from the Leaves of Garcinia polyantha. Chemistry & Biodiversity. 2014;11(6):975-981.
Lannang, A. M., Tatsimo, S. J. N., Fouotsa, H., Dzoyem, J. P., Saxena, A. K., & Sewald, N. (2014). Cytotoxic Compounds from the Leaves of Garcinia polyantha. Chemistry & Biodiversity, 11(6), 975-981.
Lannang, A. M., Tatsimo, S. J. N., Fouotsa, H., Dzoyem, J. P., Saxena, A. K., and Sewald, N. (2014). Cytotoxic Compounds from the Leaves of Garcinia polyantha. Chemistry & Biodiversity 11, 975-981.
Lannang, A.M., et al., 2014. Cytotoxic Compounds from the Leaves of Garcinia polyantha. Chemistry & Biodiversity, 11(6), p 975-981.
A.M. Lannang, et al., “Cytotoxic Compounds from the Leaves of Garcinia polyantha”, Chemistry & Biodiversity, vol. 11, 2014, pp. 975-981.
Lannang, A.M., Tatsimo, S.J.N., Fouotsa, H., Dzoyem, J.P., Saxena, A.K., Sewald, N.: Cytotoxic Compounds from the Leaves of Garcinia polyantha. Chemistry & Biodiversity. 11, 975-981 (2014).
Lannang, Alain Meli, Tatsimo, Simplice J. N., Fouotsa, Hugues, Dzoyem, Jean Paul, Saxena, Ajit Kumar, and Sewald, Norbert. “Cytotoxic Compounds from the Leaves of Garcinia polyantha”. Chemistry & Biodiversity 11.6 (2014): 975-981.
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PMID: 24934683
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