Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system

Steuwe C, Daniels JK, Frewen PA, Densmore M, Pannasch S, Beblo T, Reiss J, Lanius RA (2014)
Social Cognitive and Affective Neuroscience 9(1): 88-97.

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Abstract
In healthy individuals, direct eye contact initially leads to activation of a fast subcortical pathway, which then modulates a cortical route eliciting social cognitive processes. The aim of this study was to gain insight into the neurobiological effects of direct eye-to-eye contact using a virtual reality paradigm in individuals with posttraumatic stress disorder (PTSD) related to prolonged childhood abuse. We examined 16 healthy comparison subjects and 16 patients with a primary diagnosis of PTSD using a virtual reality functional magnetic resonance imaging paradigm involving direct vs averted gaze (happy, sad, neutral) as developed by Schrammel et al. in 2009. Irrespective of the displayed emotion, controls exhibited an increased blood oxygenation level-dependent response during direct vs averted gaze within the dorsomedial prefrontal cortex, left temporoparietal junction and right temporal pole. Under the same conditions, individuals with PTSD showed increased activation within the superior colliculus (SC)/periaqueductal gray (PAG) and locus coeruleus. Our findings suggest that healthy controls react to the exposure of direct gaze with an activation of a cortical route that enhances evaluative 'top-down' processes underlying social interactions. In individuals with PTSD, however, direct gaze leads to sustained activation of a subcortical route of eye-contact processing, an innate alarm system involving the SC and the underlying circuits of the PAG.
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Steuwe C, Daniels JK, Frewen PA, et al. Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system. Social Cognitive and Affective Neuroscience. 2014;9(1):88-97.
Steuwe, C., Daniels, J. K., Frewen, P. A., Densmore, M., Pannasch, S., Beblo, T., Reiss, J., et al. (2014). Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system. Social Cognitive and Affective Neuroscience, 9(1), 88-97.
Steuwe, C., Daniels, J. K., Frewen, P. A., Densmore, M., Pannasch, S., Beblo, T., Reiss, J., and Lanius, R. A. (2014). Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system. Social Cognitive and Affective Neuroscience 9, 88-97.
Steuwe, C., et al., 2014. Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system. Social Cognitive and Affective Neuroscience, 9(1), p 88-97.
C. Steuwe, et al., “Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system”, Social Cognitive and Affective Neuroscience, vol. 9, 2014, pp. 88-97.
Steuwe, C., Daniels, J.K., Frewen, P.A., Densmore, M., Pannasch, S., Beblo, T., Reiss, J., Lanius, R.A.: Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system. Social Cognitive and Affective Neuroscience. 9, 88-97 (2014).
Steuwe, Carolin, Daniels, Judith K., Frewen, Paul A., Densmore, Maria, Pannasch, Sebastian, Beblo, Thomas, Reiss, Jeffrey, and Lanius, Ruth A. “Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system”. Social Cognitive and Affective Neuroscience 9.1 (2014): 88-97.
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6 Citations in Europe PMC

Data provided by Europe PubMed Central.

Reward functioning in PTSD: a systematic review exploring the mechanisms underlying anhedonia.
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PMID: 25639225
Performance monitoring and behavioral adaptation during task switching: an fMRI study.
von der Gablentz J, Tempelmann C, Munte TF, Heldmann M., Neuroscience 285(), 2015
PMID: 25446349
Violence-related PTSD and neural activation when seeing emotionally charged male-female interactions.
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PMID: 25062841
Oxytocin's role in anxiety: a critical appraisal.
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65 References

Data provided by Europe PubMed Central.

Minds made for sharing: initiating joint attention recruits reward-related neurocircuitry.
Schilbach L, Wilms M, Eickhoff SB, Romanzetti S, Tepest R, Bente G, Shah NJ, Fink GR, Vogeley K., J Cogn Neurosci 22(12), 2010
PMID: 19929761
Being with virtual others: Neural correlates of social interaction.
Schilbach L, Wohlschlaeger AM, Kraemer NC, Newen A, Shah NJ, Fink GR, Vogeley K., Neuropsychologia 44(5), 2006
PMID: 16171833
Virtual friend or threat? The effects of facial expression and gaze interaction on psychophysiological responses and emotional experience.
Schrammel F, Pannasch S, Graupner ST, Mojzisch A, Velichkovsky BM., Psychophysiology 46(5), 2009
PMID: 19470127
The eye contact effect: mechanisms and development.
Senju A, Johnson MH., Trends Cogn. Sci. (Regul. Ed.) 13(3), 2009
PMID: 19217822
A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder.
Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, Macklin ML, Lasko NB, Cavanagh SR, Krangel TS, Orr SP, Pitman RK, Whalen PJ, Rauch SL., Arch. Gen. Psychiatry 62(3), 2005
PMID: 15753240
Thresholds of electrically induced defence reaction of the rat: short- and long-term adaptation mechanisms.
Sudre EC, de Barros MR, Sudre GN, Schenberg LC., Behav. Brain Res. 58(1-2), 1993
PMID: 8136042
Shared intentionality.
Tomasello M, Carpenter M., Dev Sci 10(1), 2007
PMID: 17181709
Social cognition and the brain: a meta-analysis.
Van Overwalle F., Hum Brain Mapp 30(3), 2009
PMID: 18381770
Mind reading: neural mechanisms of theory of mind and self-perspective.
Vogeley K, Bussfeld P, Newen A, Herrmann S, Happe F, Falkai P, Maier W, Shah NJ, Fink GR, Zilles K., Neuroimage 14(1 Pt 1), 2001
PMID: 11525326
Essential functions of the human self model are implemented in the prefrontal cortex.
Vogeley K, Kurthen M, Falkai P, Maier W., Conscious Cogn 8(3), 1999
PMID: 10487788
The centrencephalon and thalamocortical integration: neglected contributions of periaqueductal gray
Watt DF., 2000

Whiten A., 1991

Wilkinson M., 2010
Trauma modulates amygdala and medial prefrontal responses to consciously attended fear.
Williams LM, Kemp AH, Felmingham K, Barton M, Olivieri G, Peduto A, Gordon E, Bryant RA., Neuroimage 29(2), 2006
PMID: 16216534
The human amygdala and the emotional evaluation of sensory stimuli.
Zald DH., Brain Res. Brain Res. Rev. 41(1), 2003
PMID: 12505650

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