Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis

Mba'ning BM, Lenta BN, Noungoue DT, Antheaume C, Fongang YF, Ngouela SA, Boyom FF, Rosenthal PJ, Tsamo E, Sewald N, Laatsch H (2013)
Phytochemistry 96: 347-352.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Phytochemical investigation of the seeds of Salacia longipes var. camerunensis led to the isolation of four sesquiterpenoid derivatives, salaterpene A (1) (1 alpha,2 beta,8 beta-triacetoxy-6 beta,9 beta-dibenzoyloxy-4 beta-hydroxy-dihydro-beta-agarofuran), salaterpene B (2) (1 alpha,2 beta,8 beta-triacetoxy-9 beta-benzoyloxy-6 beta-cinnamoyloxy-4 beta-hydroxy-dihydro-beta-agarofuran), salaterpene C (3) (1 alpha,2 beta-diacetoxy-6 beta,9 beta-dibenzoyloxy-4 beta-hydroxy-dihydro-beta-agarofuran) and salaterpene D (4) (2 beta-acetoxy-1 alpha,6 beta-dibenzoyloxy-4 beta-hydroxy-9 beta-nicotinoyloxy-dihydro-beta-agarofuran) together with two known compounds (5 and 6). The structures of the compounds were established by means of NMR spectroscopy. Compounds 1-4 and 6 were tested in vitro for their antiplasmodial activity against Plasmodium falciparum chloroquine-resistant strain W2. All the tested compounds exhibited a moderate potency with IC50 below 2.7 mu M. (C) 2013 Elsevier Ltd. All rights reserved.
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Zeitschriftentitel
Phytochemistry
Band
96
Seite
347-352
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Mba'ning BM, Lenta BN, Noungoue DT, et al. Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry. 2013;96:347-352.
Mba'ning, B. M., Lenta, B. N., Noungoue, D. T., Antheaume, C., Fongang, Y. F., Ngouela, S. A., Boyom, F. F., et al. (2013). Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry, 96, 347-352. doi:10.1016/j.phytochem.2013.06.022
Mba'ning, B. M., Lenta, B. N., Noungoue, D. T., Antheaume, C., Fongang, Y. F., Ngouela, S. A., Boyom, F. F., Rosenthal, P. J., Tsamo, E., Sewald, N., et al. (2013). Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry 96, 347-352.
Mba'ning, B.M., et al., 2013. Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry, 96, p 347-352.
B.M. Mba'ning, et al., “Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis”, Phytochemistry, vol. 96, 2013, pp. 347-352.
Mba'ning, B.M., Lenta, B.N., Noungoue, D.T., Antheaume, C., Fongang, Y.F., Ngouela, S.A., Boyom, F.F., Rosenthal, P.J., Tsamo, E., Sewald, N., Laatsch, H.: Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry. 96, 347-352 (2013).
Mba'ning, Brice M., Lenta, Bruno N., Noungoue, Diderot T., Antheaume, Cyril, Fongang, Yanick F., Ngouela, Silvere A., Boyom, Fabrice F., Rosenthal, Philip J., Tsamo, Etienne, Sewald, Norbert, and Laatsch, Hartmut. “Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis”. Phytochemistry 96 (2013): 347-352.

2 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against Some Pathogenic Yeasts and Enzymes of Metabolic Significance.
Tchuente Tchuenmogne MA, Kammalac TN, Gohlke S, Kouipou RMT, Aslan A, Kuzu M, Comakli V, Demirdag R, Ngouela SA, Tsamo E, Sewald N, Lenta BN, Boyom FF., Medicines (Basel) 4(1), 2017
PMID: 28930221
A dihydro-β-agarofuran sesquiterpene from Maytenus boaria.
Paz C, von Dossow D, Tiznado V, Suarez S, Cukiernik FD, Baggio R., Acta Crystallogr C Struct Chem 73(pt 6), 2017
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