An environmental bacterial taxon with a large and distinct metabolic repertoire

Wilson MC, Mori T, Rückert C, Uria AR, Helf MJ, Takada K, Gernert C, Steffens UAE, Heycke N, Schmitt S, Rinke C, et al. (2014)
Nature 506(7486): 58-62.

Download
No fulltext has been uploaded. References only!
Journal Article | Original Article | Published | English

No fulltext has been uploaded

Author
; ; ; ; ; ; ; ; ; ; ;
All
Abstract
: Cultivated bacteria such as actinomycetes are a highly useful source of biomedically important natural products. However, such 'talented' producers represent only a minute fraction of the entire, mostly uncultivated, prokaryotic diversity. The uncultured majority is generally perceived as a large, untapped resource of new drug candidates, but so far it is unknown whether taxa containing talented bacteria indeed exist. Here we report the single-cell- and metagenomics-based discovery of such producers. Two phylotypes of the candidate genus 'Entotheonella' with genomes of greater than 9 megabases and multiple, distinct biosynthetic gene clusters co-inhabit the chemically and microbially rich marine sponge Theonella swinhoei. Almost all bioactive polyketides and peptides known from this animal were attributed to a single phylotype. 'Entotheonella' spp. are widely distributed in sponges and belong to an environmental taxon proposed here as candidate phylum 'Tectomicrobia'. The pronounced bioactivities and chemical uniqueness of 'Entotheonella' compounds provide significant opportunities for ecological studies and drug discovery.
Publishing Year
ISSN
eISSN
PUB-ID

Cite this

Wilson MC, Mori T, Rückert C, et al. An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature. 2014;506(7486):58-62.
Wilson, M. C., Mori, T., Rückert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., et al. (2014). An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature, 506(7486), 58-62. doi:10.1038/nature12959
Wilson, M. C., Mori, T., Rückert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., Steffens, U. A. E., Heycke, N., Schmitt, S., et al. (2014). An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature 506, 58-62.
Wilson, M.C., et al., 2014. An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature, 506(7486), p 58-62.
M.C. Wilson, et al., “An environmental bacterial taxon with a large and distinct metabolic repertoire”, Nature, vol. 506, 2014, pp. 58-62.
Wilson, M.C., Mori, T., Rückert, C., Uria, A.R., Helf, M.J., Takada, K., Gernert, C., Steffens, U.A.E., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E.J.N., Brachmann, A.O., Gurgui, C., Wakimoto, T., Kracht, M., Crüsemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J.: An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature. 506, 58-62 (2014).
Wilson, Micheal C, Mori, Tetsushi, Rückert, Christian, Uria, Agustinus R, Helf, Maximilian J, Takada, Kentaro, Gernert, Christine, Steffens, Ursula A E, Heycke, Nina, Schmitt, Susanne, Rinke, Christian, Helfrich, Eric J N, Brachmann, Alexander O, Gurgui, Cristian, Wakimoto, Toshiyuki, Kracht, Matthias, Crüsemann, Max, Hentschel, Ute, Abe, Ikuro, Matsunaga, Shigeki, Kalinowski, Jörn, Takeyama, Haruko, and Piel, Jörn. “An environmental bacterial taxon with a large and distinct metabolic repertoire”. Nature 506.7486 (2014): 58-62.
This data publication is cited in the following publications:
This publication cites the following data publications:

153 Citations in Europe PMC

Data provided by Europe PubMed Central.

Microbiology: a talented genus.
Jaspars M, Challis G., Nature 506(7486), 2014
PMID: 24476822
A new benzofuran glycoside and indole alkaloids from a sponge-associated rare actinomycete, Amycolatopsis sp.
Kwon Y, Kim SH, Shin Y, Bae M, Kim BY, Lee SK, Oh KB, Shin J, Oh DC., Mar Drugs 12(4), 2014
PMID: 24759001
Recent advances in genome-based polyketide discovery.
Helfrich EJ, Reiter S, Piel J., Curr Opin Biotechnol 29(), 2014
PMID: 24762576

66 References

Data provided by Europe PubMed Central.


AUTHOR UNKNOWN, 0
SINA: accurate high-throughput multiple sequence alignment of ribosomal RNA genes.
Pruesse E, Peplies J, Glockner FO., Bioinformatics 28(14), 2012
PMID: 22556368
ARB: a software environment for sequence data.
Ludwig W, Strunk O, Westram R, Richter L, Meier H, Yadhukumar , Buchner A, Lai T, Steppi S, Jobb G, Forster W, Brettske I, Gerber S, Ginhart AW, Gross O, Grumann S, Hermann S, Jost R, Konig A, Liss T, Lussmann R, May M, Nonhoff B, Reichel B, Strehlow R, Stamatakis A, Stuckmann N, Vilbig A, Lenke M, Ludwig T, Bode A, Schleifer KH., Nucleic Acids Res. 32(4), 2004
PMID: 14985472
SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB.
Pruesse E, Quast C, Knittel K, Fuchs BM, Ludwig W, Peplies J, Glockner FO., Nucleic Acids Res. 35(21), 2007
PMID: 17947321
Accelerated Profile HMM Searches.
Eddy SR., PLoS Comput. Biol. 7(10), 2011
PMID: 22039361
FastTree 2--approximately maximum-likelihood trees for large alignments.
Price MN, Dehal PS, Arkin AP., PLoS ONE 5(3), 2010
PMID: 20224823
RAxML-Light: a tool for computing terabyte phylogenies.
Stamatakis A, Aberer AJ, Goll C, Smith SA, Berger SA, Izquierdo-Carrasco F., Bioinformatics 28(15), 2012
PMID: 22628519
Insights into the biosynthesis of hormaomycin, an exceptionally complex bacterial signaling metabolite.
Hofer I, Crusemann M, Radzom M, Geers B, Flachshaar D, Cai X, Zeeck A, Piel J., Chem. Biol. 18(3), 2011
PMID: 21439483

AUTHOR UNKNOWN, 0
Clustering millions of tandem mass spectra.
Frank AM, Bandeira N, Shen Z, Tanner S, Briggs SP, Smith RD, Pevzner PA., J. Proteome Res. 7(1), 2008
PMID: 18067247
Protein identification by spectral networks analysis.
Bandeira N, Tsur D, Frank A, Pevzner PA., Proc. Natl. Acad. Sci. U.S.A. 104(15), 2007
PMID: 17404225
Cytoscape: a software environment for integrated models of biomolecular interaction networks.
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T., Genome Res. 13(11), 2003
PMID: 14597658

Export

0 Marked Publications

Open Data PUB

Web of Science

View record in Web of Science®

Sources

PMID: 24476823
PubMed | Europe PMC

Search this title in

Google Scholar