Hepatic involvement in patients with HIV infection: Discrepancies between AIDS patients and patients with earlier stages of HIV infection

Prüfer-Krämer L, Krämer A, Weigel R, Rögler G, Fleige B, Krause PH, Hahn EG, Riecken EO, Pohle HD (1991)
Journal of Infectious Diseases 163(4): 866-869.

Journal Article | Published | English

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Abstract
The effect of human immunodeficiency virus (HIV) infection on type and severity of liver disease was studied in 61 HIV-positive patients who did not have AIDS and in 45 AIDS patients. Liver biopsies revealed viral hepatitis in 12 of 18 non-AIDS patients but in only 4 of 34 AIDS patients (P < .0005, Fisher's exact test). Acute, non-A non-B, and chronic active hepatitis B were seen exclusively in the non-AIDS group; however,chronic persistent hepatitis B was seen in both groups. In 9 of 18AIDS patients intra vitam liver histopathology established diagnoses of opportunistic infections or tumors. Tissue reaction to certain pathogens, such as hepatitis B virus, mycobacteria, and cryptococci, seems to bemilder in AIDS patients than in others who are HIV positive or the expected reaction of the normal host. This is likely because of impaired cell-mediated immunity in patients with advanced HIV disease.
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Prüfer-Krämer L, Krämer A, Weigel R, et al. Hepatic involvement in patients with HIV infection: Discrepancies between AIDS patients and patients with earlier stages of HIV infection. Journal of Infectious Diseases. 1991;163(4):866-869.
Prüfer-Krämer, L., Krämer, A., Weigel, R., Rögler, G., Fleige, B., Krause, P. H., Hahn, E. G., et al. (1991). Hepatic involvement in patients with HIV infection: Discrepancies between AIDS patients and patients with earlier stages of HIV infection. Journal of Infectious Diseases, 163(4), 866-869.
Prüfer-Krämer, L., Krämer, A., Weigel, R., Rögler, G., Fleige, B., Krause, P. H., Hahn, E. G., Riecken, E. O., and Pohle, H. D. (1991). Hepatic involvement in patients with HIV infection: Discrepancies between AIDS patients and patients with earlier stages of HIV infection. Journal of Infectious Diseases 163, 866-869.
Prüfer-Krämer, L., et al., 1991. Hepatic involvement in patients with HIV infection: Discrepancies between AIDS patients and patients with earlier stages of HIV infection. Journal of Infectious Diseases, 163(4), p 866-869.
L. Prüfer-Krämer, et al., “Hepatic involvement in patients with HIV infection: Discrepancies between AIDS patients and patients with earlier stages of HIV infection”, Journal of Infectious Diseases, vol. 163, 1991, pp. 866-869.
Prüfer-Krämer, L., Krämer, A., Weigel, R., Rögler, G., Fleige, B., Krause, P.H., Hahn, E.G., Riecken, E.O., Pohle, H.D.: Hepatic involvement in patients with HIV infection: Discrepancies between AIDS patients and patients with earlier stages of HIV infection. Journal of Infectious Diseases. 163, 866-869 (1991).
Prüfer-Krämer, Luise, Krämer, Alexander, Weigel, Roland, Rögler, Gertrud, Fleige, Barbara, Krause, Peter H., Hahn, Eckart G., Riecken, Ernst Otto, and Pohle, Hans Dieter. “Hepatic involvement in patients with HIV infection: Discrepancies between AIDS patients and patients with earlier stages of HIV infection”. Journal of Infectious Diseases 163.4 (1991): 866-869.
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