Heritability of life span is largely sex limited in Drosophila

Lehtovaara A, Schielzeth H, Flis I, Friberg U (2013)
The American Naturalist 182(5): 653-665.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Males and females differ with respect to life span and rate of aging in most animal species. Such sexual dimorphism can be associated with a complex genetic architecture, where only part of the genetic variation is shared between the sexes. However, the extent to which this is true for life span and aging is not known, because studies of life span have given contradictory results and aging has not been studied from this perspective. Here we investigate the additive genetic architecture of life span and aging in Drosophila melanogaster. We find substantial amounts of additive genetic variation for both traits, with more than three-quarters of this variation available for sex-specific evolutionary change. This result shows that the sexes have a profoundly different additive genetic basis for these traits, which has several implications. First, it translates into an, on average, three-times-higher heritability of life span within, compared to between, the sexes. Second, it implies that the sexes are relatively free to evolve with respect to these traits. And third, as life span and aging are traits that integrate over all genetic factors that contribute to mortal disease, it also implies that the genetics of heritable disease differs vastly between the sexes.
Erscheinungsjahr
Zeitschriftentitel
The American Naturalist
Band
182
Zeitschriftennummer
5
Seite
653-665
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Lehtovaara A, Schielzeth H, Flis I, Friberg U. Heritability of life span is largely sex limited in Drosophila. The American Naturalist. 2013;182(5):653-665.
Lehtovaara, A., Schielzeth, H., Flis, I., & Friberg, U. (2013). Heritability of life span is largely sex limited in Drosophila. The American Naturalist, 182(5), 653-665. doi:10.1086/673296
Lehtovaara, A., Schielzeth, H., Flis, I., and Friberg, U. (2013). Heritability of life span is largely sex limited in Drosophila. The American Naturalist 182, 653-665.
Lehtovaara, A., et al., 2013. Heritability of life span is largely sex limited in Drosophila. The American Naturalist, 182(5), p 653-665.
A. Lehtovaara, et al., “Heritability of life span is largely sex limited in Drosophila”, The American Naturalist, vol. 182, 2013, pp. 653-665.
Lehtovaara, A., Schielzeth, H., Flis, I., Friberg, U.: Heritability of life span is largely sex limited in Drosophila. The American Naturalist. 182, 653-665 (2013).
Lehtovaara, Anne, Schielzeth, Holger, Flis, Ilona, and Friberg, Urban. “Heritability of life span is largely sex limited in Drosophila”. The American Naturalist 182.5 (2013): 653-665.

11 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits.
Traglia M, Bseiso D, Gusev A, Adviento B, Park DS, Mefford JA, Zaitlen N, Weiss LA., Genetics 205(2), 2017
PMID: 27974502
Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span.
Garschall K, Dellago H, Gáliková M, Schosserer M, Flatt T, Grillari J., NPJ Aging Mech Dis 3(), 2017
PMID: 28649423
Sex-specific Tradeoffs With Growth and Fitness Following Life-span Extension by Rapamycin in an Outcrossing Nematode, Caenorhabditis remanei.
Lind MI, Zwoinska MK, Meurling S, Carlsson H, Maklakov AA., J Gerontol A Biol Sci Med Sci 71(7), 2016
PMID: 26472877
Selection on learning performance results in the correlated evolution of sexual dimorphism in life history.
Zwoinska MK, Lind MI, Cortazar-Chinarro M, Ramsden M, Maklakov AA., Evolution 70(2), 2016
PMID: 26787139
Evolution under dietary restriction increases male reproductive performance without survival cost.
Zajitschek F, Zajitschek SR, Canton C, Georgolopoulos G, Friberg U, Maklakov AA., Proc Biol Sci 283(1825), 2016
PMID: 26911958
Within-population Y-linked genetic variation for lifespan in Drosophila melanogaster.
Griffin RM, Le Gall D, Schielzeth H, Friberg U., J Evol Biol 28(11), 2015
PMID: 26230387
Sexual conflict, life span, and aging.
Adler MI, Bonduriansky R., Cold Spring Harb Perspect Biol 6(8), 2014
PMID: 24938876

71 References

Daten bereitgestellt von Europe PubMed Central.

Heritability of life span in the Old Order Amish.
Mitchell BD, Hsueh WC, King TM, Pollin TI, Sorkin J, Agarwala R, Schaffer AA, Shuldiner AR., Am. J. Med. Genet. 102(4), 2001
PMID: 11503162

AUTHOR UNKNOWN, 0
Survival analysis of life span quantitative trait loci in Drosophila melanogaster.
Nuzhdin SV, Khazaeli AA, Curtsinger JW., Genetics 170(2), 2005
PMID: 15834144

AUTHOR UNKNOWN, 0
Sex-specific genetic architecture of human disease.
Ober C, Loisel DA, Gilad Y., Nat. Rev. Genet. 9(12), 2008
PMID: 19002143
Beyond the evolutionary theory of ageing, from functional genomics to evo-gero.
Partridge L, Gems D., Trends Ecol. Evol. (Amst.) 21(6), 2006
PMID: 16769434

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0
Age-specific patterns of genetic variance in Drosophila melanogaster. I. Mortality.
Promislow DE, Tatar M, Khazaeli AA, Curtsinger JW., Genetics 143(2), 1996
PMID: 8725232

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0
Environment-dependent survival of Drosophila melanogaster: a quantitative genetic analysis.
Wang MH, Lazebny O, Harshman LG, Nuzhdin SV., Aging Cell 3(3), 2004
PMID: 15153181
Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster.
Vieira C, Pasyukova EG, Zeng ZB, Hackett JB, Lyman RF, Mackay TF., Genetics 154(1), 2000
PMID: 10628982
Evidence for a genetic basis of aging in two wild vertebrate populations.
Wilson AJ, Nussey DH, Pemberton JM, Pilkington JG, Morris A, Pelletier F, Clutton-Brock TH, Kruuk LE., Curr. Biol. 17(24), 2007
PMID: 18083516
No intra-locus sexual conflict over reproductive fitness or ageing in field crickets.
Zajitschek F, Hunt J, Zajitschek SR, Jennions MD, Brooks R., PLoS ONE 2(1), 2007
PMID: 17225859

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