In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples

Pereira UP, Soares SC, Blom J, Leal CAG, Ramos RT .J, Guimarães LC, Oliveira L .C, Almeida SS, Hassan SS, Santos AR, Miyoshi A, et al. (2013)
Genetics and molecular research : GMR 12(3): 2902-2912.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Streptococcus agalactiae (Lancefield group B; group B streptococci) is a major pathogen that causes meningoencephalitis in fish, mastitis in cows, and neonatal sepsis and meningitis in humans. The available prophylactic measures for conserving human and animal health are not totally effective and have limitations. Effective vaccines against the different serotypes or genotypes of pathogenic strains from the various hosts would be useful. We used an in silico strategy to identify conserved vaccine candidates in 15 genomes of group B streptococci strains isolated from human, bovine, and fish samples. The degree of conservation, subcellular localization, and immunogenic potential of S. agalactiae proteins were investigated. We identified 36 antigenic proteins that were conserved in all 15 genomes. Among these proteins, 5 and 23 were shared only by human or fish strains, respectively. These potential vaccine targets may help develop effective vaccines that will help prevent S. agalactiae infection.
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Genetics and molecular research : GMR
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12
Zeitschriftennummer
3
Seite
2902-2912
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Pereira UP, Soares SC, Blom J, et al. In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples. Genetics and molecular research : GMR. 2013;12(3):2902-2912.
Pereira, U. P., Soares, S. C., Blom, J., Leal, C. A. G., Ramos, R. T. .J., Guimarães, L. C., Oliveira, L. .C., et al. (2013). In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples. Genetics and molecular research : GMR, 12(3), 2902-2912. doi:10.4238/2013.August.12.6
Pereira, U. P., Soares, S. C., Blom, J., Leal, C. A. G., Ramos, R. T. .J., Guimarães, L. C., Oliveira, L. .C., Almeida, S. S., Hassan, S. S., Santos, A. R., et al. (2013). In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples. Genetics and molecular research : GMR 12, 2902-2912.
Pereira, U.P., et al., 2013. In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples. Genetics and molecular research : GMR, 12(3), p 2902-2912.
U.P. Pereira, et al., “In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples”, Genetics and molecular research : GMR, vol. 12, 2013, pp. 2902-2912.
Pereira, U.P., Soares, S.C., Blom, J., Leal, C.A.G., Ramos, R.T. .J., Guimarães, L.C., Oliveira, L. .C., Almeida, S.S., Hassan, S.S., Santos, A.R., Miyoshi, A., Silva, A., Tauch, A., Barh, D., Azevedo, V., Figueiredo, H.C.P.: In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples. Genetics and molecular research : GMR. 12, 2902-2912 (2013).
Pereira, U. P., Soares, S. C., Blom, J., Leal, C. A. G., Ramos, R. T. .J., Guimarães, L. C., Oliveira, L .C., Almeida, S. S., Hassan, S. S., Santos, A. R., Miyoshi, A., Silva, A., Tauch, Andreas, Barh, D., Azevedo, V., and Figueiredo, H. C. P. “In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples”. Genetics and molecular research : GMR 12.3 (2013): 2902-2912.

6 Zitationen in Europe PMC

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Lopera-Madrid J, Osorio JE, He Y, Xiang Z, Adams LG, Laughlin RC, Mwangi W, Subramanya S, Neilan J, Brake D, Burrage TG, Brown WC, Clavijo A, Bounpheng MA., Vet Immunol Immunopathol 185(), 2017
PMID: 28241999
Development of a single-dose recombinant CAMP factor entrapping poly(lactide-co-glycolide) microspheres-based vaccine against Streptococcus agalactiae.
Liu G, Yin J, Barkema HW, Chen L, Shahid M, Szenci O, De Buck J, Kastelic JP, Han B., Vaccine 35(9), 2017
PMID: 28162819
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PMID: 27491974
A recombinant truncated surface immunogenic protein (tSip) plus adjuvant FIA confers active protection against Group B streptococcus infection in tilapia.
He Y, Wang KY, Xiao D, Chen DF, Huang L, Liu T, Wang J, Geng Y, Wang EL, Yang Q., Vaccine 32(51), 2014
PMID: 25446833

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