Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone

Staudt S, Bornscheuer UT, Menyes U, Hummel W, Gröger H (2013)
Enzyme and microbial technology 53(4): 288-292.

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Abstract
The development of a biocatalytic process concept for ɛ-caprolactone, which directly converts cyclohexanol as an easily available industrial raw material into the desired ɛ-caprolactone in a one-pot fashion while only requiring air as sole reagent, is reported. The desired product ɛ-caprolactone was obtained with 94-97% conversion when operating at a substrate concentration in the range of 20-60mM. At higher substrate concentrations, however, a significant drop of conversion was found. Subsequent detailed studies on the impact of the starting material, intermediate and product components revealed a significant inhibition and partial deactivation of the BVMO by the product ɛ-caprolactone (in particular at higher concentrations) as well as an inhibition of the BVMO by cyclohexanol and cyclohexanone.
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Staudt S, Bornscheuer UT, Menyes U, Hummel W, Gröger H. Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone. Enzyme and microbial technology. 2013;53(4):288-292.
Staudt, S., Bornscheuer, U. T., Menyes, U., Hummel, W., & Gröger, H. (2013). Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone. Enzyme and microbial technology, 53(4), 288-292.
Staudt, S., Bornscheuer, U. T., Menyes, U., Hummel, W., and Gröger, H. (2013). Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone. Enzyme and microbial technology 53, 288-292.
Staudt, S., et al., 2013. Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone. Enzyme and microbial technology, 53(4), p 288-292.
S. Staudt, et al., “Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone”, Enzyme and microbial technology, vol. 53, 2013, pp. 288-292.
Staudt, S., Bornscheuer, U.T., Menyes, U., Hummel, W., Gröger, H.: Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone. Enzyme and microbial technology. 53, 288-292 (2013).
Staudt, Svenja, Bornscheuer, Uwe T, Menyes, Ulf, Hummel, Werner, and Gröger, Harald. “Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone”. Enzyme and microbial technology 53.4 (2013): 288-292.
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