Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production

Soares SC, Trost E, Ramos RTJ, Carneiro AR, Santos AR, Pinto AC, Barbosa E, Aburjaile F, Ali A, Diniz CAA, Hassan SS, et al. (2013)
Journal of Biotechnology 167(2): 135-141.

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Abstract
Corynebacterium pseudotuberculosis is the causative agent of several veterinary diseases in a broad range of economically important hosts, which can vary from caseous lymphadenitis in sheep and goats (biovar ovis) to ulcerative lymphangitis in cattle and horses (biovar equi). Existing vaccines against C. pseudotuberculosis are mainly intended for small ruminants and, even in these hosts, they still present remarkable limitations. In this study, we present the complete genome sequence of C. pseudotuberculosis biovar equi strain 258, isolated from a horse with ulcerative lymphangitis. The genome has a total size of 2,314,404bp and contains 2088 predicted protein-coding regions. Using in silico analysis, eleven pathogenicity islands were detected in the genome sequence of C. pseudotuberculosis 258. The application of a reverse vaccinology strategy identified 49 putative antigenic proteins, which can be used as candidate vaccine targets in future works.
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Soares SC, Trost E, Ramos RTJ, et al. Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production. Journal of Biotechnology. 2013;167(2):135-141.
Soares, S. C., Trost, E., Ramos, R. T. J., Carneiro, A. R., Santos, A. R., Pinto, A. C., Barbosa, E., et al. (2013). Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production. Journal of Biotechnology, 167(2), 135-141.
Soares, S. C., Trost, E., Ramos, R. T. J., Carneiro, A. R., Santos, A. R., Pinto, A. C., Barbosa, E., Aburjaile, F., Ali, A., Diniz, C. A. A., et al. (2013). Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production. Journal of Biotechnology 167, 135-141.
Soares, S.C., et al., 2013. Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production. Journal of Biotechnology, 167(2), p 135-141.
S.C. Soares, et al., “Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production”, Journal of Biotechnology, vol. 167, 2013, pp. 135-141.
Soares, S.C., Trost, E., Ramos, R.T.J., Carneiro, A.R., Santos, A.R., Pinto, A.C., Barbosa, E., Aburjaile, F., Ali, A., Diniz, C.A.A., Hassan, S.S., Fiaux, K., Guimarães, L.C., Bakhtiar, S.M., Pereira, U., Almeida, S.S., Abreu, V.A.C., Rocha, F.S., Dorella, F.A., Miyoshi, A., Silva, A., Azevedo, V., Tauch, A.: Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production. Journal of Biotechnology. 167, 135-141 (2013).
Soares, Siomar C., Trost, Eva, Ramos, Rommel T. J., Carneiro, Adriana R., Santos, Anderson R., Pinto, Anne C., Barbosa, Eudes, Aburjaile, Flávia, Ali, Amjad, Diniz, Carlos A. A., Hassan, Syed S., Fiaux, Karina, Guimarães, Luis C., Bakhtiar, Syeda M., Pereira, Ulisses, Almeida, Sintia S., Abreu, Vinícius A. C., Rocha, Flávia S., Dorella, Fernanda A., Miyoshi, Anderson, Silva, Artur, Azevedo, Vasco, and Tauch, Andreas. “Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production”. Journal of Biotechnology 167.2 (2013): 135-141.
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4 Citations in Europe PMC

Data provided by Europe PubMed Central.

Corynebacterium pseudotuberculosis Pneumonia in a Veterinary Student Infected During Laboratory Work.
Heggelund L, Gaustad P, Havelsrud OE, Blom J, Borgen L, Sundset A, Sorum H, Froland SS., Open Forum Infect Dis 2(2), 2015
PMID: 26380345
An integrated structural proteomics approach along the druggable genome of Corynebacterium pseudotuberculosis species for putative druggable targets.
Radusky LG, Hassan S, Lanzarotti E, Tiwari S, Jamal S, Ali J, Ali A, Ferreira R, Barh D, Silva A, Turjanski AG, Azevedo VA., BMC Genomics 16 Suppl 5(), 2015
PMID: 26041381
Proteome scale comparative modeling for conserved drug and vaccine targets identification in Corynebacterium pseudotuberculosis.
Hassan SS, Tiwari S, Guimaraes LC, Jamal SB, Folador E, Sharma NB, de Castro Soares S, Almeida S, Ali A, Islam A, Povoa FD, de Abreu VA, Jain N, Bhattacharya A, Juneja L, Miyoshi A, Silva A, Barh D, Turjanski A, Azevedo V, Ferreira RS., BMC Genomics 15 Suppl 7(), 2014
PMID: 25573232
Genome Sequence of Corynebacterium pseudotuberculosis MB20 bv. equi Isolated from a Pectoral Abscess of an Oldenburg Horse in California.
Barauna RA, Guimaraes LC, Veras AA, de Sa PH, Gracas DA, Pinheiro KC, Silva AS, Folador EL, Benevides LJ, Viana MV, Carneiro AR, Schneider MP, Spier SJ, Edman JM, Ramos RT, Azevedo V, Silva A., Genome Announc 2(6), 2014
PMID: 25395628

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