Combining Genomics and Metabolomics for the Discovery of Regulatory Genes and Their Use in Metabolic Engineering to Produce 'Healthy Foods'

Martin C, Luo J, Lebouteiller B, Mock HP, Matros A, Peterek S, Schijlen EGWM, Hall R, Shintu L, Colquhoun I, Weisshaar B, et al. (2012)
Acta Horticulturae 941: 73-84.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ; ; ; ; ; ; ; ;
Alle
Abstract / Bemerkung
Plants often accumulate their natural products to relatively low levels, so there is a lot of interest in breeding or engineering plants that produce higher levels. It has been shown that the most effective way to increase the accumulation of secondary metabolites is to increase the activity of genes that regulate the activity of the biosynthetic pathways that make different natural products. Regulatory genes of this type encode proteins called transcription factors. The biggest bottleneck in using this strategy to develop plants that accumulate significantly higher levels of important natural products is that not many transcription factors regulating secondary metabolism have yet been identified at the molecular level. Genes encoding transcription factors can be identified from model plants with sequenced genomes. The ability of such genes to regulate metabolism can be assayed by examination of mutants (reverse genetics) and by investigating the metabolic effects of high levels of expression of the genes. The combined techniques of metabolic fingerprinting and metabolite profiling of mutant and transgenic plants are allowing us to identify new genes encoding transcription factors controlling secondary metabolism, that can be used as tools for engineering natural product accumulation.
Erscheinungsjahr
Zeitschriftentitel
Acta Horticulturae
Band
941
Seite
73-84
Konferenz
First International Symposium on Genetic Modifications - Challenges and Opportunities for Horticulture in the World
Konferenzort
Ski, Norway
ISSN
PUB-ID

Zitieren

Martin C, Luo J, Lebouteiller B, et al. Combining Genomics and Metabolomics for the Discovery of Regulatory Genes and Their Use in Metabolic Engineering to Produce 'Healthy Foods'. Acta Horticulturae. 2012;941:73-84.
Martin, C., Luo, J., Lebouteiller, B., Mock, H. P., Matros, A., Peterek, S., Schijlen, E. G. W. M., et al. (2012). Combining Genomics and Metabolomics for the Discovery of Regulatory Genes and Their Use in Metabolic Engineering to Produce 'Healthy Foods'. Acta Horticulturae, 941, 73-84.
Martin, C., Luo, J., Lebouteiller, B., Mock, H. P., Matros, A., Peterek, S., Schijlen, E. G. W. M., Hall, R., Shintu, L., Colquhoun, I., et al. (2012). Combining Genomics and Metabolomics for the Discovery of Regulatory Genes and Their Use in Metabolic Engineering to Produce 'Healthy Foods'. Acta Horticulturae 941, 73-84.
Martin, C., et al., 2012. Combining Genomics and Metabolomics for the Discovery of Regulatory Genes and Their Use in Metabolic Engineering to Produce 'Healthy Foods'. Acta Horticulturae, 941, p 73-84.
C. Martin, et al., “Combining Genomics and Metabolomics for the Discovery of Regulatory Genes and Their Use in Metabolic Engineering to Produce 'Healthy Foods'”, Acta Horticulturae, vol. 941, 2012, pp. 73-84.
Martin, C., Luo, J., Lebouteiller, B., Mock, H.P., Matros, A., Peterek, S., Schijlen, E.G.W.M., Hall, R., Shintu, L., Colquhoun, I., Weisshaar, B., Butelli, E.: Combining Genomics and Metabolomics for the Discovery of Regulatory Genes and Their Use in Metabolic Engineering to Produce 'Healthy Foods'. Acta Horticulturae. 941, 73-84 (2012).
Martin, Cathie, Luo, Jie, Lebouteiller, B., Mock, H.P., Matros, A., Peterek, S., Schijlen, E.G.W.M., Hall, R., Shintu, L., Colquhoun, I., Weisshaar, Bernd, and Butelli, E. “Combining Genomics and Metabolomics for the Discovery of Regulatory Genes and Their Use in Metabolic Engineering to Produce 'Healthy Foods'”. Acta Horticulturae 941 (2012): 73-84.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Suchen in

Google Scholar
ISBN Suche