Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water

Staudt S, Burda E, Giese C, Müller CA, Marienhagen J, Schwaneberg U, Hummel W, Drauz K, Gröger H (2013)
Angewandte Chemie International Edition 52(8): 2359-2363.

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Abstract
It doesn't take much to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP(+) (and a little 2-propanol to reduce it), as well as two catalytic enzymes-a hydroxylating P450 monooxygenase and an alcohol dehydrogenase. (Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
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Staudt S, Burda E, Giese C, et al. Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water. Angewandte Chemie International Edition. 2013;52(8):2359-2363.
Staudt, S., Burda, E., Giese, C., Müller, C. A., Marienhagen, J., Schwaneberg, U., Hummel, W., et al. (2013). Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water. Angewandte Chemie International Edition, 52(8), 2359-2363.
Staudt, S., Burda, E., Giese, C., Müller, C. A., Marienhagen, J., Schwaneberg, U., Hummel, W., Drauz, K., and Gröger, H. (2013). Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water. Angewandte Chemie International Edition 52, 2359-2363.
Staudt, S., et al., 2013. Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water. Angewandte Chemie International Edition, 52(8), p 2359-2363.
S. Staudt, et al., “Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water”, Angewandte Chemie International Edition, vol. 52, 2013, pp. 2359-2363.
Staudt, S., Burda, E., Giese, C., Müller, C.A., Marienhagen, J., Schwaneberg, U., Hummel, W., Drauz, K., Gröger, H.: Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water. Angewandte Chemie International Edition. 52, 2359-2363 (2013).
Staudt, Svenja, Burda, Edyta, Giese, Carolin, Müller, Christina A., Marienhagen, Jan, Schwaneberg, Ulrich, Hummel, Werner, Drauz, Karlheinz, and Gröger, Harald. “Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water”. Angewandte Chemie International Edition 52.8 (2013): 2359-2363.
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5 Citations in Europe PMC

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Recent trends and novel concepts in cofactor-dependent biotransformations.
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