Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential

Simon S, Osswald S, Roos J, Gröger H (2012)
Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences 67b(10): 1123-1126.

Journal Article | Published | English

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Abstract
Diethyl malonate turned out to be both a "green" and highly efficient acyl donor in the lipase-catalyzed resolution of amines, thus representing an attractive alternative to currently applied acyl donors. By means of this acyl donor a highly efficient enzymatic process for the resolution of amines, running at high substrate input of up to 200 g/L in an organic solvent classified as "usable" according to the Pfizer Solvent Selection Guide, is presented.
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Simon S, Osswald S, Roos J, Gröger H. Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential. Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences. 2012;67b(10):1123-1126.
Simon, S., Osswald, S., Roos, J., & Gröger, H. (2012). Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential. Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences, 67b(10), 1123-1126.
Simon, S., Osswald, S., Roos, J., and Gröger, H. (2012). Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential. Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences 67b, 1123-1126.
Simon, S., et al., 2012. Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential. Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences, 67b(10), p 1123-1126.
S. Simon, et al., “Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential”, Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences, vol. 67b, 2012, pp. 1123-1126.
Simon, S., Osswald, S., Roos, J., Gröger, H.: Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential. Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences. 67b, 1123-1126 (2012).
Simon, Sabine, Osswald, Steffen, Roos, Juergen, and Gröger, Harald. “Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential”. Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences 67b.10 (2012): 1123-1126.
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