Oxidative Burst Inhibitory and Cytotoxic Activity of Constituents of the Fruits of Odyendyea gabonensis

Donkwe SMM, Happi EN, Wansi J, Lenta BN, Devkota KP, Neumann B, Stammler H-G, Sewald N (2012)
Planta Medica 78(18): 1949-1956.

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Abstract
The methanol extract of dried fruits of Odyendyea gabonensis afforded one new quassinoid [(-)-odyendanol (1)], one new canthin-6-one alkaloid [9-hydroxy-5-methoxycanthin-6-one (4)], and two new steroids [22E, 24R-stigmasta-5,22-diene-3,7-dione (7) and 22E,24R-stigmast-22-ene-3,7-dione (8)] along with fourteen known compounds. The structures of all compounds were established by analyzing the spectroscopic data. The C-13-NMR values of (-)-odyendene (2) and (-)-odyendane (3), as well as the single-crystal X-ray structure of 5-methoxycanthin-6-one (6) are also reported. The oxidative burst inhibitory activity of pure compounds 1-12 was determined by the chemo-luminescence assay, and cytotoxic activities of compounds 2-6 against the human prostate cancer cell PC-3 line were evaluated. Compounds 1-6 exhibited a clear suppressive effect on the phagocytosis response upon activation with serum-opsonized zymosan in the range of IC50 = 0.9-2.0 mu M versus ibuprofen with IC50 = 12.1 mu M, while all canthin-6-one alkaloids (4-6) displayed moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC50 values ranging from 13.5-15.4 mu M versus doxorubicine with IC50 = 1.5 mu M.
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Donkwe SMM, Happi EN, Wansi J, et al. Oxidative Burst Inhibitory and Cytotoxic Activity of Constituents of the Fruits of Odyendyea gabonensis. Planta Medica. 2012;78(18):1949-1956.
Donkwe, S. M. M., Happi, E. N., Wansi, J., Lenta, B. N., Devkota, K. P., Neumann, B., Stammler, H. - G., et al. (2012). Oxidative Burst Inhibitory and Cytotoxic Activity of Constituents of the Fruits of Odyendyea gabonensis. Planta Medica, 78(18), 1949-1956.
Donkwe, S. M. M., Happi, E. N., Wansi, J., Lenta, B. N., Devkota, K. P., Neumann, B., Stammler, H. - G., and Sewald, N. (2012). Oxidative Burst Inhibitory and Cytotoxic Activity of Constituents of the Fruits of Odyendyea gabonensis. Planta Medica 78, 1949-1956.
Donkwe, S.M.M., et al., 2012. Oxidative Burst Inhibitory and Cytotoxic Activity of Constituents of the Fruits of Odyendyea gabonensis. Planta Medica, 78(18), p 1949-1956.
S.M.M. Donkwe, et al., “Oxidative Burst Inhibitory and Cytotoxic Activity of Constituents of the Fruits of Odyendyea gabonensis”, Planta Medica, vol. 78, 2012, pp. 1949-1956.
Donkwe, S.M.M., Happi, E.N., Wansi, J., Lenta, B.N., Devkota, K.P., Neumann, B., Stammler, H.-G., Sewald, N.: Oxidative Burst Inhibitory and Cytotoxic Activity of Constituents of the Fruits of Odyendyea gabonensis. Planta Medica. 78, 1949-1956 (2012).
Donkwe, Suzye Mireille Moladje, Happi, Emmanuel Ngeufa, Wansi, Jean, Lenta, Bruno Ndjakou, Devkota, Krishna Prasad, Neumann, Beate, Stammler, Hans-Georg, and Sewald, Norbert. “Oxidative Burst Inhibitory and Cytotoxic Activity of Constituents of the Fruits of Odyendyea gabonensis”. Planta Medica 78.18 (2012): 1949-1956.
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Hill RA, Connolly JD., Nat Prod Rep 32(2), 2015
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