An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence.

Tegetmeyer H, Fricke K, Baltes N (2009)
Veterinary Microbiology 137(3-4): 392-396.

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AasP, an autotransporter serine protease of Actinobacillus pleuropneumoniae, has been shown to be expressed in necrotic porcine lung tissue. Based on the hypothesis that AasP might play an important role in A. pleuropneumoniae adhesion and virulence by processing other surface-associated proteins, the predicted catalytic site of AasP was deleted and the isogenic mutant, AP76DeltaaasP, was compared to the wild-type strain in a biofilm assay as well as an aerosol infection model. AP76DeltaaasP showed increased adherence compared to the wild-type strain under standard culturing conditions as well as under NAD restriction. No significant differences between AP76 wild-type and AP76DeltaaasP were observed upon experimental infection of pigs, indicating that AasP does not play a crucial role in A. pleuropneumoniae virulence.
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Tegetmeyer H, Fricke K, Baltes N. An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence. Veterinary Microbiology. 2009;137(3-4):392-396.
Tegetmeyer, H., Fricke, K., & Baltes, N. (2009). An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence. Veterinary Microbiology, 137(3-4), 392-396. doi:10.1016/j.vetmic.2009.01.026
Tegetmeyer, H., Fricke, K., and Baltes, N. (2009). An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence. Veterinary Microbiology 137, 392-396.
Tegetmeyer, H., Fricke, K., & Baltes, N., 2009. An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence. Veterinary Microbiology, 137(3-4), p 392-396.
H. Tegetmeyer, K. Fricke, and N. Baltes, “An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence.”, Veterinary Microbiology, vol. 137, 2009, pp. 392-396.
Tegetmeyer, H., Fricke, K., Baltes, N.: An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence. Veterinary Microbiology. 137, 392-396 (2009).
Tegetmeyer, Halina, Fricke, Kerstin, and Baltes, Nina. “An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence.”. Veterinary Microbiology 137.3-4 (2009): 392-396.
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7 Citations in Europe PMC

Data provided by Europe PubMed Central.

Global effects of catecholamines on Actinobacillus pleuropneumoniae gene expression.
Li L, Xu Z, Zhou Y, Sun L, Liu Z, Chen H, Zhou R., PLoS ONE 7(2), 2012
PMID: 22347439
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PMID: 20969814
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PMID: 19737507
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Oldfield NJ, Worrall KE, Rycroft AN, Ali T, Wooldridge KG, Ala'Aldeen DA., Vaccine 27(38), 2009
PMID: 19563888

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