Regulation of the V-Type ATPase by Redox-Modulation

Seidel T, Scholl S, Krebs M, Rienmüller F, Marten I, Hedrich R, Hanitzsch M, Janetzki P, Dietz K-J, Schumacher K (2012)
The Biochemical Journal 448(2): 243-251.

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ATP-hydrolysis and proton pumping by the vacuolar-type proton translocating ATPase (V-ATPase) are subject to redox regulation in mammals, yeast and plants. Oxidative inhibition of the V-ATPase is ascribed to disulfide-bond formation between conserved cysteine residues at the catalytic site of subunit A. Subunits containing amino acid substitutions of one of three conserved cysteine residues of VHA-A were expressed in a vha-A null mutant background in Arabidopsis. In vitro activity measurements revealed a complete absence of oxidative inhibition in the transgenic line expressing VHA-A C256S confirming that C256 is necessary for redox regulation. In contrast, oxidative inhibition was unaffected in plants expressing VHA-A C279S and VHA-A C535S indicating that disulfide bridges involving these cysteine residues are not essential for oxidative inhibition. In vivo data suggest that oxidative inhibition might not represent a general regulatory mechanism in plants.
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Seidel T, Scholl S, Krebs M, et al. Regulation of the V-Type ATPase by Redox-Modulation. The Biochemical Journal. 2012;448(2):243-251.
Seidel, T., Scholl, S., Krebs, M., Rienmüller, F., Marten, I., Hedrich, R., Hanitzsch, M., et al. (2012). Regulation of the V-Type ATPase by Redox-Modulation. The Biochemical Journal, 448(2), 243-251.
Seidel, T., Scholl, S., Krebs, M., Rienmüller, F., Marten, I., Hedrich, R., Hanitzsch, M., Janetzki, P., Dietz, K. - J., and Schumacher, K. (2012). Regulation of the V-Type ATPase by Redox-Modulation. The Biochemical Journal 448, 243-251.
Seidel, T., et al., 2012. Regulation of the V-Type ATPase by Redox-Modulation. The Biochemical Journal, 448(2), p 243-251.
T. Seidel, et al., “Regulation of the V-Type ATPase by Redox-Modulation”, The Biochemical Journal, vol. 448, 2012, pp. 243-251.
Seidel, T., Scholl, S., Krebs, M., Rienmüller, F., Marten, I., Hedrich, R., Hanitzsch, M., Janetzki, P., Dietz, K.-J., Schumacher, K.: Regulation of the V-Type ATPase by Redox-Modulation. The Biochemical Journal. 448, 243-251 (2012).
Seidel, Thorsten, Scholl, Stefan, Krebs, Melanie, Rienmüller, Florian, Marten, Irene, Hedrich, Rainer, Hanitzsch, Miriam, Janetzki, Patricia, Dietz, Karl-Josef, and Schumacher, Karin. “Regulation of the V-Type ATPase by Redox-Modulation”. The Biochemical Journal 448.2 (2012): 243-251.
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