Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products

Zahoor ul Hassan A, Lindner S, Wendisch VF (2012)
Computational and Structural Biotechnology Journal 3(4): e201210004.

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Abstract
Corynebacterium glutamicum is well known as the amino acid-producing workhorse of fermentation industry, being used for multi-million-ton scale production of glutamate and lysine for more than 60 years. However, it is only recently that extensive research has focused on engineering it beyond the scope of amino acids. Meanwhile, a variety of corynebacterial strains allows access to alternative carbon sources and/or allows production of a wide range of industrially relevant compounds. Some of these efforts set new standards in terms of titers and productivities achieved whereas others represent a proof-of-principle. These achievements manifest the position of C. glutamicum as an important industrial microorganism with capabilities far beyond the traditional amino acid production. In this review we focus on the state of the art of metabolic engineeringof C. glutamicum for utilization of alternative carbon sources, (e.g. coming from wastes and unprocessed sources), and construction of C. glutamicum strains for production of new products such as diamines, organic acids and alcohols.
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Zahoor ul Hassan A, Lindner S, Wendisch VF. Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products. Computational and Structural Biotechnology Journal. 2012;3(4): e201210004.
Zahoor ul Hassan, A., Lindner, S., & Wendisch, V. F. (2012). Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products. Computational and Structural Biotechnology Journal, 3(4), e201210004. doi:10.5936/csbj.201210004
Zahoor ul Hassan, A., Lindner, S., and Wendisch, V. F. (2012). Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products. Computational and Structural Biotechnology Journal 3:e201210004.
Zahoor ul Hassan, A., Lindner, S., & Wendisch, V.F., 2012. Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products. Computational and Structural Biotechnology Journal, 3(4): e201210004.
A. Zahoor ul Hassan, S. Lindner, and V.F. Wendisch, “Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products”, Computational and Structural Biotechnology Journal, vol. 3, 2012, : e201210004.
Zahoor ul Hassan, A., Lindner, S., Wendisch, V.F.: Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products. Computational and Structural Biotechnology Journal. 3, : e201210004 (2012).
Zahoor ul Hassan, Ahmed, Lindner, Steffen, and Wendisch, Volker F. “Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products”. Computational and Structural Biotechnology Journal 3.4 (2012): e201210004.
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