Adult Craniofacial Stem Cells: Sources and Relation to the Neural Crest

Kaltschmidt B, Kaltschmidt C, Widera D (2012)
Stem Cell Reviews and Reports 8(3): 658-671.

Journal Article | Published | English

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Abstract
During the process of development, neural crest cells migrate out from their niche between the newly formed ectoderm and the neural tube. Thereafter, they give rise not only to ectodermal cell types, but also to mesodermal cell types. Cell types with neural crest ancestry consequently comprise a number of specialized varieties, such as ectodermal neurons, melanocytes and Schwann cells, as well as mesodermal osteoblasts, adipocytes and smooth muscle cells. Numerous recent studies suggest that stem cells with a neural crest origin persist into adulthood, especially within the mammalian craniofacial compartment. This review discusses the sources of adult neural crest-derived stem cells (NCSCs) derived from the cranium, as well as their differentiation potential and expression of key stem cell markers. Furthermore, the expression of marker genes associated with embryonic stem cells and the issue of multi- versus pluripotency of adult NCSCs is reviewed. Stringent tests are proposed, which, if performed, are anticipated to clarify the issue of adult NCSC potency. Finally, current pre-clinical and clinical data are discussed in light of the clinical impact of adult NCSCs.
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Kaltschmidt B, Kaltschmidt C, Widera D. Adult Craniofacial Stem Cells: Sources and Relation to the Neural Crest. Stem Cell Reviews and Reports. 2012;8(3):658-671.
Kaltschmidt, B., Kaltschmidt, C., & Widera, D. (2012). Adult Craniofacial Stem Cells: Sources and Relation to the Neural Crest. Stem Cell Reviews and Reports, 8(3), 658-671.
Kaltschmidt, B., Kaltschmidt, C., and Widera, D. (2012). Adult Craniofacial Stem Cells: Sources and Relation to the Neural Crest. Stem Cell Reviews and Reports 8, 658-671.
Kaltschmidt, B., Kaltschmidt, C., & Widera, D., 2012. Adult Craniofacial Stem Cells: Sources and Relation to the Neural Crest. Stem Cell Reviews and Reports, 8(3), p 658-671.
B. Kaltschmidt, C. Kaltschmidt, and D. Widera, “Adult Craniofacial Stem Cells: Sources and Relation to the Neural Crest”, Stem Cell Reviews and Reports, vol. 8, 2012, pp. 658-671.
Kaltschmidt, B., Kaltschmidt, C., Widera, D.: Adult Craniofacial Stem Cells: Sources and Relation to the Neural Crest. Stem Cell Reviews and Reports. 8, 658-671 (2012).
Kaltschmidt, Barbara, Kaltschmidt, Christian, and Widera, Darius. “Adult Craniofacial Stem Cells: Sources and Relation to the Neural Crest”. Stem Cell Reviews and Reports 8.3 (2012): 658-671.
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Data provided by Europe PubMed Central.

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Locher H, Saadah N, de Groot S, de Groot JC, Frijns JH, Huisman MA., Histochem. Cell Biol. 144(1), 2015
PMID: 25724811
Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in parkinsonian rats.
Muller J, Ossig C, Greiner JF, Hauser S, Fauser M, Widera D, Kaltschmidt C, Storch A, Kaltschmidt B., Stem Cells Transl Med 4(1), 2015
PMID: 25479965
Alternative generation of CNS neural stem cells and PNS derivatives from neural crest-derived peripheral stem cells.
Weber M, Apostolova G, Widera D, Mittelbronn M, Dechant G, Kaltschmidt B, Rohrer H., Stem Cells 33(2), 2015
PMID: 25331182
Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction.
Jiang MH, Cai B, Tuo Y, Wang J, Zang ZJ, Tu X, Gao Y, Su Z, Li W, Li G, Zhang M, Jiao J, Wan Z, Deng C, Lahn BT, Xiang AP., Cell Res. 24(12), 2014
PMID: 25418539
The neural crest, a multifaceted structure of the vertebrates.
Dupin E, Le Douarin NM., Birth Defects Res. C Embryo Today 102(3), 2014
PMID: 25219958
Generation of induced pluripotent stem cells from hair follicle bulge neural crest stem cells.
Ma MS, Czepiel M, Krause T, Schafer KH, Boddeke E, Copray S., Cell Reprogram 16(5), 2014
PMID: 25084290
Formation of cartilage and synovial tissue by human gingival stem cells.
Ferre FC, Larjava H, Loison-Robert LS, Berbar T, Owen GR, Berdal A, Cherifi H, Gogly B, Hakkinen L, Fournier BP., Stem Cells Dev. 23(23), 2014
PMID: 25003637
Interaction of adult human neural crest-derived stem cells with a nanoporous titanium surface is sufficient to induce their osteogenic differentiation.
Schurmann M, Wolff A, Widera D, Hauser S, Heimann P, Hutten A, Kaltschmidt C, Kaltschmidt B., Stem Cell Res 13(1), 2014
PMID: 24858494
Culture bag systems for clinical applications of adult human neural crest-derived stem cells.
Greiner JF, Grunwald LM, Muller J, Sudhoff H, Widera D, Kaltschmidt C, Kaltschmidt B., Stem Cell Res Ther 5(2), 2014
PMID: 24629140
Hair curvature: a natural dialectic and review.
Nissimov JN, Das Chaudhuri AB., Biol Rev Camb Philos Soc 89(3), 2014
PMID: 24617997
Human stem cells for craniomaxillofacial reconstruction.
Jalali M, Kirkpatrick WN, Cameron MG, Pauklin S, Vallier L., Stem Cells Dev. 23(13), 2014
PMID: 24564584
Tissue interactions in neural crest cell development and disease.
Takahashi Y, Sipp D, Enomoto H., Science 341(6148), 2013
PMID: 23970693
Gingiva as a source of stem cells with therapeutic potential.
Fournier BP, Larjava H, Hakkinen L., Stem Cells Dev. 22(24), 2013
PMID: 23944935

110 References

Data provided by Europe PubMed Central.

Pluripotency: toward a gold standard for human ES and iPS cells.
Smith KP, Luong MX, Stein GS., J. Cell. Physiol. 220(1), 2009
PMID: 19326392
Epidermal neural crest stem cell (EPI-NCSC)--mediated recovery of sensory function in a mouse model of spinal cord injury.
Hu YF, Gourab K, Wells C, Clewes O, Schmit BD, Sieber-Blum M., Stem Cell Rev 6(2), 2010
PMID: 20414748
Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial.
Mackay-Sim A, Feron F, Cochrane J, Bassingthwaighte L, Bayliss C, Davies W, Fronek P, Gray C, Kerr G, Licina P, Nowitzke A, Perry C, Silburn PA, Urquhart S, Geraghty T., Brain 131(Pt 9), 2008
PMID: 18689435

J, Neuroscience Research 69(), 2010
Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease.
Murrell W, Wetzig A, Donnellan M, Feron F, Burne T, Meedeniya A, Kesby J, Bianco J, Perry C, Silburn P, Mackay-Sim A., Stem Cells 26(8), 2008
PMID: 18535154
Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions.
Nivet E, Vignes M, Girard SD, Pierrisnard C, Baril N, Deveze A, Magnan J, Lante F, Khrestchatisky M, Feron F, Roman FS., J. Clin. Invest. 121(7), 2011
PMID: 21670501
Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair.
Lavoie JF, Biernaskie JA, Chen Y, Bagli D, Alman B, Kaplan DR, Miller FD., Stem Cells Dev. 18(6), 2009
PMID: 18834279
Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes.
d'Aquino R, De Rosa A, Lanza V, Tirino V, Laino L, Graziano A, Desiderio V, Laino G, Papaccio G., Eur Cell Mater 18(), 2009
PMID: 19908196

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