Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

Barreiro C, Prieto C, Sola-Landa A, Solera E, Martinez-Castro M, Perez-Redondo R, Garcia-Estrada C, Aparicio JF, Fernandez-Martinez LT, Santos-Aberturas J, Salehi-Najafabadi Z, et al. (2012)
Journal of bacteriology 194(14): 3756-3757.

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Abstract
The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.
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Barreiro C, Prieto C, Sola-Landa A, et al. Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of bacteriology. 2012;194(14):3756-3757.
Barreiro, C., Prieto, C., Sola-Landa, A., Solera, E., Martinez-Castro, M., Perez-Redondo, R., Garcia-Estrada, C., et al. (2012). Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of bacteriology, 194(14), 3756-3757. doi:10.1128/JB.00692-12
Barreiro, C., Prieto, C., Sola-Landa, A., Solera, E., Martinez-Castro, M., Perez-Redondo, R., Garcia-Estrada, C., Aparicio, J. F., Fernandez-Martinez, L. T., Santos-Aberturas, J., et al. (2012). Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of bacteriology 194, 3756-3757.
Barreiro, C., et al., 2012. Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of bacteriology, 194(14), p 3756-3757.
C. Barreiro, et al., “Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)”, Journal of bacteriology, vol. 194, 2012, pp. 3756-3757.
Barreiro, C., Prieto, C., Sola-Landa, A., Solera, E., Martinez-Castro, M., Perez-Redondo, R., Garcia-Estrada, C., Aparicio, J.F., Fernandez-Martinez, L.T., Santos-Aberturas, J., Salehi-Najafabadi, Z., Rodriguez-Garcia, A., Tauch, A., Martin, J.F.: Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of bacteriology. 194, 3756-3757 (2012).
Barreiro, Carlos, Prieto, Carlos, Sola-Landa, Alberto, Solera, Elena, Martinez-Castro, Miriam, Perez-Redondo, Rosario, Garcia-Estrada, Carlos, Aparicio, Jesus F, Fernandez-Martinez, Lorena T, Santos-Aberturas, Javier, Salehi-Najafabadi, Zahra, Rodriguez-Garcia, Antonio, Tauch, Andreas, and Martin, Juan F. “Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)”. Journal of bacteriology 194.14 (2012): 3756-3757.
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18 Citations in Europe PMC

Data provided by Europe PubMed Central.

dRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptome.
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Tang J, Liu X, Peng J, Tang Y, Zhang Y., Appl Microbiol Biotechnol 99(6), 2015
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Barreiro C, Martínez-Castro M., Appl Microbiol Biotechnol 98(2), 2014
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The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control.
Salehi-Najafabadi Z, Barreiro C, Rodríguez-García A, Cruz A, López GE, Martín JF., Appl Microbiol Biotechnol 98(11), 2014
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Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'.
Martínez-Castro M, Salehi-Najafabadi Z, Romero F, Pérez-Sanchiz R, Fernández-Chimeno RI, Martín JF, Barreiro C., Appl Microbiol Biotechnol 97(5), 2013
PMID: 22990582
Streptomyces tsukubensis sp. nov., a producer of the immunosuppressant tacrolimus.
Muramatsu H, Nagai K., J Antibiot (Tokyo) 66(4), 2013
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Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds.
Walsh CT, O'Brien RV, Khosla C., Angew Chem Int Ed Engl 52(28), 2013
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Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster.
Jones AC, Gust B, Kulik A, Heide L, Buttner MJ, Bibb MJ., PLoS One 8(7), 2013
PMID: 23874942
Expression of the endogenous and heterologous clavulanic acid cluster in Streptomyces flavogriseus: why a silent cluster is sleeping.
Alvarez-Álvarez R, Martínez-Burgo Y, Pérez-Redondo R, Braña AF, Martín JF, Liras P., Appl Microbiol Biotechnol 97(21), 2013
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Annotation of the modular polyketide synthase and nonribosomal peptide synthetase gene clusters in the genome of Streptomyces tsukubaensis NRRL18488.
Blazic M, Starcevic A, Lisfi M, Baranasic D, Goranovic D, Fujs S, Kuscer E, Kosec G, Petkovic H, Cullum J, Hranueli D, Zucko J., Appl Environ Microbiol 78(23), 2012
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