Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

Barreiro C, Prieto C, Sola-Landa A, Solera E, Martinez-Castro M, Perez-Redondo R, Garcia-Estrada C, Aparicio JF, Fernandez-Martinez LT, Santos-Aberturas J, Salehi-Najafabadi Z, et al. (2012)
Journal of bacteriology 194(14): 3756-3757.

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Abstract
The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.
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Barreiro C, Prieto C, Sola-Landa A, et al. Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of bacteriology. 2012;194(14):3756-3757.
Barreiro, C., Prieto, C., Sola-Landa, A., Solera, E., Martinez-Castro, M., Perez-Redondo, R., Garcia-Estrada, C., et al. (2012). Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of bacteriology, 194(14), 3756-3757.
Barreiro, C., Prieto, C., Sola-Landa, A., Solera, E., Martinez-Castro, M., Perez-Redondo, R., Garcia-Estrada, C., Aparicio, J. F., Fernandez-Martinez, L. T., Santos-Aberturas, J., et al. (2012). Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of bacteriology 194, 3756-3757.
Barreiro, C., et al., 2012. Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of bacteriology, 194(14), p 3756-3757.
C. Barreiro, et al., “Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)”, Journal of bacteriology, vol. 194, 2012, pp. 3756-3757.
Barreiro, C., Prieto, C., Sola-Landa, A., Solera, E., Martinez-Castro, M., Perez-Redondo, R., Garcia-Estrada, C., Aparicio, J.F., Fernandez-Martinez, L.T., Santos-Aberturas, J., Salehi-Najafabadi, Z., Rodriguez-Garcia, A., Tauch, A., Martin, J.F.: Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506). Journal of bacteriology. 194, 3756-3757 (2012).
Barreiro, Carlos, Prieto, Carlos, Sola-Landa, Alberto, Solera, Elena, Martinez-Castro, Miriam, Perez-Redondo, Rosario, Garcia-Estrada, Carlos, Aparicio, Jesus F, Fernandez-Martinez, Lorena T, Santos-Aberturas, Javier, Salehi-Najafabadi, Zahra, Rodriguez-Garcia, Antonio, Tauch, Andreas, and Martin, Juan F. “Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)”. Journal of bacteriology 194.14 (2012): 3756-3757.
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12 Citations in Europe PMC

Data provided by Europe PubMed Central.

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The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control.
Salehi-Najafabadi Z, Barreiro C, Rodriguez-Garcia A, Cruz A, Lopez GE, Martin JF., Appl. Microbiol. Biotechnol. 98(11), 2014
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Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506).
Barreiro C, Martinez-Castro M., Appl. Microbiol. Biotechnol. 98(2), 2014
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Understanding and manipulating antibiotic production in actinomycetes.
Bibb MJ., Biochem. Soc. Trans. 41(6), 2013
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Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster.
Jones AC, Gust B, Kulik A, Heide L, Buttner MJ, Bibb MJ., PLoS ONE 8(7), 2013
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Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds.
Walsh CT, O'Brien RV, Khosla C., Angew. Chem. Int. Ed. Engl. 52(28), 2013
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Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'.
Martinez-Castro M, Salehi-Najafabadi Z, Romero F, Perez-Sanchiz R, Fernandez-Chimeno RI, Martin JF, Barreiro C., Appl. Microbiol. Biotechnol. 97(5), 2013
PMID: 22990582
Annotation of the modular polyketide synthase and nonribosomal peptide synthetase gene clusters in the genome of Streptomyces tsukubaensis NRRL18488.
Blazic M, Starcevic A, Lisfi M, Baranasic D, Goranovic D, Fujs S, Kuscer E, Kosec G, Petkovic H, Cullum J, Hranueli D, Zucko J., Appl. Environ. Microbiol. 78(23), 2012
PMID: 22983969

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